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. 1980 Oct;42(4):551–558. doi: 10.1038/bjc.1980.279

Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice.

A Gabizon, N Trainin
PMCID: PMC2010444  PMID: 6969087

Abstract

The effect of lymphocytes from normal mice on the growth of a syngeneic, radiation-induced, T-cell-derived lymphoma was investigated. Thymus and spleen cells enhanced the growth of admixed lymphoma cells in a reproducible manner. Growth enhancement was manifested by the earlier appearance and higher final incidence of tumours. Lymphocytes also enhanced the growth of radiation-damaged lymphoma cells. The enhancing activity of spleen cells was predominantly a property of T cells, since it was abolished by treatment with anti-theta serum plus complement and significantly less in spleen cells of nude mice. Tumour-enhancing thymocytes seem to belong to the immature thymic subpopulation, as indicated by their binding to peanut agglutinin.

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Selected References

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