Abstract
1330 consecutively diagnosed breast-cancer patients, and an equal number of paired aged-matched controls without breast cancer, were investigated for a familial history of breast cancer. Patients and controls received identical questionnaires. One relative or more with breast cancer was reported by 18.6% of the patients and by 12.3% of the controls, giving a standardized relative risk (SRR) of 1.6 (P < 0.01). One or more first-degree relatives with breast cancer were reported by 11.2% of the patients and by 6.8% of the controls, with an SRR of 1.7 (P < 0.01). For second-degree relatives the SRR was 1.5 (P < 0.05). Of the patients, 3.9% had mothers with breast cancer compared to 2.7% of the controls (SRR = 1.4, N.S.). One or more sisters with breast canceer were reported by 10.1% of the patients and by 5.1% of the controls (SRR = 2.0, P < 0.01). No distinct difference in familiality between the different age groups was found.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adami H. O., Rimsten A. Prevalence of hypertension and diabetes in breast cancer: a case-control study in 179 patients and age-matched, non-hospitalized controls. Clin Oncol. 1978 Sep;4(3):243–249. [PubMed] [Google Scholar]
- Adami H. O., Rimsten A., Stenkvist B., Vegelius J. Influence of height, weight and obesity on risk of breast cancer in an unselected Swedish population. Br J Cancer. 1977 Dec;36(6):787–792. doi: 10.1038/bjc.1977.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Adami H. O., Rimsten A., Stenkvist B., Vegelius J. Reproductive history and risk of breast cancer: a case-control study in an unselected Swedish population. Cancer. 1978 Feb;41(2):747–757. doi: 10.1002/1097-0142(197802)41:2<747::aid-cncr2820410248>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
- Adami H. O., Rimsten A., Thorén L., Vegelius J., Wide L. Thyroid disease and function in breast cancer patients and non-hospitalized controls evaluated by determination of TSH, T3, rT3 and T4 levels in serum. Acta Chir Scand. 1978;144(2):89–97. [PubMed] [Google Scholar]
- Anderson D. E. Genetic study of breast cancer: identification of a high risk group. Cancer. 1974 Oct;34(4):1090–1097. doi: 10.1002/1097-0142(197410)34:4<1090::aid-cncr2820340419>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
- Anderson D. E. Some characteristics of familial breast cancer. Cancer. 1971 Dec;28(6):1500–1504. doi: 10.1002/1097-0142(197112)28:6<1500::aid-cncr2820280623>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
- Henderson B. E., Powell D., Rosario I., Keys C., Hanisch R., Young M., Casagrande J., Gerkins V., Pike M. C. An epidemiologic study of breast cancer. J Natl Cancer Inst. 1974 Sep;53(3):609–614. doi: 10.1093/jnci/53.3.609. [DOI] [PubMed] [Google Scholar]
- Lilienfeld A. M. Formal discussion of: genetic factors in the etiology of cancer: an epidemiologic view. Cancer Res. 1965 Sep;25(8):1330–1335. [PubMed] [Google Scholar]
- Miettinen O. S. Standardization of risk ratios. Am J Epidemiol. 1972 Dec;96(6):383–388. doi: 10.1093/oxfordjournals.aje.a121470. [DOI] [PubMed] [Google Scholar]
- Morgan R. W., Vakil D. V., Chipman M. L. Breast feeding, family history, and breast disease. Am J Epidemiol. 1974 Feb;99(2):117–122. doi: 10.1093/oxfordjournals.aje.a121591. [DOI] [PubMed] [Google Scholar]
- Petrakis N. L. Genetic factors in the etiology of breast cancer. Cancer. 1977 Jun;39(6 Suppl):2709–2715. doi: 10.1002/1097-0142(197706)39:6<2709::aid-cncr2820390658>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
- Thiessen E. U. Concerning a familial association between breast cancer and both prostatic and uterine malignancies. Cancer. 1974 Oct;34(4):1102–1107. doi: 10.1002/1097-0142(197410)34:4<1102::aid-cncr2820340421>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]