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. 1980 Jul;42(1):95–102. doi: 10.1038/bjc.1980.207

Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats.

J P Sunter, D L Hull, D R Appleton, A J Watson
PMCID: PMC2010484  PMID: 7426333

Abstract

We have measured mitotic indices and 3H-thymidine-labelling indices for the colonic epithelial tumours induced in rats by the administration of dimethyl-hydrazine (DMH). The fraction-of-labelled-mitoses (FLM) technique has been used to estimate the duration of the cell-cycle phases. In general, mitotic and labelling indices in the tumours are similar to those in the proliferation zone of the normal crypt epithelium; lesions considered to be least well differentiated on histological grounds appear to have the lowest mean labelling index. Benign tumours and the different types of malignant tumours have mean cell-cycle times about half those of the normal mucosa.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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