Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1981 Feb;43(2):196–200. doi: 10.1038/bjc.1981.28

Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours.

M Russo, R Giancane, G Apice, B Galanti
PMCID: PMC2010514  PMID: 6781524

Abstract

Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) levels of peripheral blood mononuclear cells were measured in 34 patients with various types of solid tumours. The mean ADA activity was found to be significantly lower than in controls (P less than 0.005). Patients with nonresectable tumour or with recurrence after radical surgery showed low ADA levels, while patients operated upon and without recurrence had enzymatic activity not different from that of normal controls. The mean value of PNP activity was similar to that of normal controls; no differences were observed between operated patients without recurrence and cases with nonresectable tumour or with recurrence after surgical treatment. No effects on ADA and PNP levels appeared to be induced by chemotherapy.

Full text

PDF
196

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHANEY A. L., MARBACH E. P. Modified reagents for determination of urea and ammonia. Clin Chem. 1962 Apr;8:130–132. [PubMed] [Google Scholar]
  2. Chen S. H., Ochs H. D., Scott C. R., Giblett E. R. Adenosine deaminase and nucleoside phosphorylase activity in patients with immunodeficiency syndromes. Clin Immunol Immunopathol. 1979 Jun;13(2):156–160. doi: 10.1016/0090-1229(79)90059-x. [DOI] [PubMed] [Google Scholar]
  3. Gelfand E. W., Dosch H. M., Biggar W. D., Fox I. H. Partial purine nucleoside phosphorylase deficiency. Studies of lymphocyte function. J Clin Invest. 1978 Apr;61(4):1071–1080. doi: 10.1172/JCI109006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Giblett E. R., Ammann A. J., Wara D. W., Sandman R., Diamond L. K. Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity. Lancet. 1975 May 3;1(7914):1010–1013. doi: 10.1016/s0140-6736(75)91950-9. [DOI] [PubMed] [Google Scholar]
  5. Giblett E. R., Anderson J. E., Cohen F., Pollara B., Meuwissen H. J. Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity. Lancet. 1972 Nov 18;2(7786):1067–1069. doi: 10.1016/s0140-6736(72)92345-8. [DOI] [PubMed] [Google Scholar]
  6. Lum C. T., Sutherland D. E., Yasmineh W. G., Najarian J. S. Peripheral blood mononuclear cell adenosine deaminase activity in renal allograft recipients. J Surg Res. 1978 May;24(5):388–395. doi: 10.1016/0022-4804(78)90032-x. [DOI] [PubMed] [Google Scholar]
  7. Meier J., Coleman M. S., Hutton J. J. Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies. Br J Cancer. 1976 Mar;33(3):312–319. doi: 10.1038/bjc.1976.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mejer J., Nygaard P. Adenosine deaminase and purine nucleoside phosphorylase levels in acute myeloblastic leukemia cells. Relationship to diagnosis and clinical course. Leuk Res. 1979;3(4):211–216. doi: 10.1016/0145-2126(79)90044-4. [DOI] [PubMed] [Google Scholar]
  9. Meuwissen H. J., Pollara B., Pickering R. J. Combined immunodeficiency disease associated with adenosine deaminase deficiency. Report on a workshop held in Albany, New York, October 1, 1973. J Pediatr. 1975 Feb;86(2):169–181. doi: 10.1016/s0022-3476(75)80463-x. [DOI] [PubMed] [Google Scholar]
  10. Ogawa K., Tominaga K., Taoka S., Yata K., Tsubura E. Adenosine deaminase and purine nucleoside phosphorylase activities in lymphocytes from patients with lung cancer. Gan. 1978 Aug;69(4):471–475. [PubMed] [Google Scholar]
  11. Parkman R., Gelfand E. W., Rosen F. S., Sanderson A., Hirschhorn R. Severe combined immunodeficiency and adenosine deaminase deficiency. N Engl J Med. 1975 Apr 3;292(14):714–719. doi: 10.1056/NEJM197504032921402. [DOI] [PubMed] [Google Scholar]
  12. Sandman R., Ammann A. J., Grose C., Wara D. W. Cellular immunodeficiency associated with nucleoside phosphorylase deficiency. Immunologic and biochemical studies. Clin Immunol Immunopathol. 1977 Sep;8(2):247–253. doi: 10.1016/0090-1229(77)90114-3. [DOI] [PubMed] [Google Scholar]
  13. Sidi Y., Boer P., Pick I., Pinkhas J., Sperling O. Increased adenosine deaminase activity in peripheral lymphocytes in Waldenström's macroglobulinemia. Lancet. 1979 Mar 3;1(8114):500–500. doi: 10.1016/s0140-6736(79)90862-6. [DOI] [PubMed] [Google Scholar]
  14. Smyth J. F., Harrap K. R. Adenosine deaminase activity in leukaemia. Br J Cancer. 1975 May;31(5):544–549. doi: 10.1038/bjc.1975.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Stoop J. W., Zegers B. J., Hendrickx G. F., van Heukelom L. H., Staal G. E., de Bree P. K., Wadman S. K., Ballieux R. E. Purine nucleoside phosphorylase deficiency associated with selective cellular immunodeficiency. N Engl J Med. 1977 Mar 24;296(12):651–655. doi: 10.1056/NEJM197703242961203. [DOI] [PubMed] [Google Scholar]
  16. Tung R., Silber R., Quagliata F., Conklyn M., Gottesman J., Hirschhorn R. Adenosine deaminase activity in chronic lymphocytic leukemia. Relationship to B- and T-cell subpopulations. J Clin Invest. 1976 Mar;57(3):756–761. doi: 10.1172/JCI108334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Uberti J., Johnson R. M., Talley R., Lightbody J. J. Decreased lymphocyte adenosine deaminase activity in tumor patients. Cancer Res. 1976 Jun;36(6):2046–2047. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES