Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1980 Dec;42(6):922–928. doi: 10.1038/bjc.1980.341

Tumorigenesis by N-n-propyl-N-formylhydrazine in mice.

B Toth, D Nagel, K Patil
PMCID: PMC2010578  PMID: 7459225

Abstract

Continuous administration of 0.04% N-n-propyl-N-formylhydrazine (PFH) for life in drinking water to 6-week-old randomly bred Swiss mice induced tumours of the lungs, preputial glands, liver and gallbladder. The tumour incidences in these 4 tissues were 91, 22, 8 and 6%, whereas in the untreated controls they were 25, 0, 0.5 and 0.5%, respectively. The higher dose of 0.08% PFH, given under identical conditions, induced only tumours of the lungs, liver and gall bladder in low incidences, since the compound was too toxic for the mice. Histopathologically, the tumours were classified as adenomas and adenocarcinomas of the lungs, squamous-cell papillomas, and carcinomas and fibrosarcoma of preputial glands, benign hepatomas and liver-cell carcinoma, as well as adenomas and adenocarcinoma of the gall bladder. The investigation is part of our structure/activity relationship inquiry aimed at revealing the mechanism of action of the N-alkyl-N-formylhydrazine series of chemicals.

Full text

PDF
922

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIANCIFIORI C., RIBACCHI R. Pulmonary tumours in mice induced by oral isoniazid and its metabolites. Nature. 1962 May 5;194:488–489. doi: 10.1038/194488a0. [DOI] [PubMed] [Google Scholar]
  2. Hiraga K., Fujii T. Tumors of the preputial gland in rats. Gan. 1977 Jun;68(3):369–370. [PubMed] [Google Scholar]
  3. LaRue T. A. Naturally occurring compounds Containing a nitrogen-nitrogen bond. Lloydia. 1977 Jul-Aug;40(4):307–321. [PubMed] [Google Scholar]
  4. List P. H., Luft P. Gyromitrin, das Gift der Frühjahrslorchel. 16. Uber Pilzinhaltsstoffe. Arch Pharm Ber Dtsch Pharm Ges. 1968 Apr;301(4):294–305. doi: 10.1002/ardp.19683010410. [DOI] [PubMed] [Google Scholar]
  5. Morris J. E., Price J. M., Lalich J. J., Stein R. J. The carcinogenic activity of some 5-nitrofuran derivatives in the rat. Cancer Res. 1969 Dec;29(12):2145–2156. [PubMed] [Google Scholar]
  6. Peto R. Editorial: Guidelines on the analysis of tumour rates and death rates in experimental animals. Br J Cancer. 1974 Feb;29(2):101–105. doi: 10.1038/bjc.1974.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Pyysalo H., Niskanen A. On the occurrence of N-methyl-N-formylhydrazones in fresh and processed false morel, Gyromitra esculenta. J Agric Food Chem. 1977 May-Jun;25(3):644–647. doi: 10.1021/jf60211a006. [DOI] [PubMed] [Google Scholar]
  8. Schmeltz I., Abidi S., Hoffmann D. Tumorigenic agents in unburned processed tobacco: N-nitrosodiethanolamine and 1,1-dimethylhydrazine. Cancer Lett. 1977 Jan;2(3):125–131. doi: 10.1016/s0304-3835(77)80001-3. [DOI] [PubMed] [Google Scholar]
  9. TOTH B., MAGEE P. N., SHUBIK P. CARCINOGENESIS STUDY WITH DIMETHYLNITROSAMINE ADMINISTERED ORALLY TO ADULT AND SUBCUTANEOUSLY TO NEWBORN BALB-C MICE. Cancer Res. 1964 Nov;24:1712–1721. [PubMed] [Google Scholar]
  10. Toth B. Actual new cancer-causing hydrazines, hydrazides, and hydrazones. J Cancer Res Clin Oncol. 1980;97(2):97–108. doi: 10.1007/BF00409895. [DOI] [PubMed] [Google Scholar]
  11. Toth B., Nagel D., Patil K. Tumorigenic action of N-n-butyl-N-formylhydrazine in mice. Carcinogenesis. 1980 Jul;1(7):589–593. doi: 10.1093/carcin/1.7.589. [DOI] [PubMed] [Google Scholar]
  12. Toth B., Nagel D. Tumors induced in mice by N-methyl-N-formylhydrazine of the false morel Gyromitra esculenta. J Natl Cancer Inst. 1978 Jan;60(1):201–204. doi: 10.1093/jnci/60.1.201. [DOI] [PubMed] [Google Scholar]
  13. Toth B., Patil K., Erickson J., Kupper R. False morel mushroom Gyromitra esculenta toxin: N-methyl-N-formylhdrazine carcinogenesis in mice. Mycopathologia. 1979 Sep 17;68(2):121–128. doi: 10.1007/BF00441091. [DOI] [PubMed] [Google Scholar]
  14. Toth B., Shimizu H. 1-Carbamyl-2-phenylhydrazine tumorigenesis in Swiss mice. Morphology of lung adenomas. J Natl Cancer Inst. 1974 Jan;52(1):241–251. doi: 10.1093/jnci/52.1.241. [DOI] [PubMed] [Google Scholar]
  15. Toth B. Synthetic and naturally occurring hydrazines as possible cancer causative agents. Cancer Res. 1975 Dec;35(12):3693–3697. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES