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. 1981 Mar;43(3):261–266. doi: 10.1038/bjc.1981.43

Characterization of human sarcoma antigen S3.

J K Sethi, Y Hirshaut
PMCID: PMC2010596  PMID: 6164380

Abstract

An antigen common to human sarcomas, S3, has been further characterized. It is antigenically distinct from human blood-group substances A and B and from heterophile antigens such as Forssman, infectious mononucleosis and serum sickness antigens. Whilst S3 antigen preparations may contain small amounts of CEA and AFP there is no correlation between S3 antigen and the presence or amount of these known tumour-associated substances. S3 antibody can be fully absorbed with guinea-pig kidney but not boiled beef or SRBC. S3, therefore, is a heterophile substance which has not previously been identified. A seroepidemiological survey confirms that S3-antibody prevalence is significantly increased in persons with a wide variety of malignant disease, as well as in family members of patients with sarcoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fogh J., Fogh H. Procedures for control of mycoplasma contamination of tissue cultures. Ann N Y Acad Sci. 1969 Dec 16;172(2):15–30. doi: 10.1111/j.1749-6632.1969.tb34961.x. [DOI] [PubMed] [Google Scholar]
  2. Hirshaut Y., Glade P., Moses H., Manaker R., Chessin L. Association of herpes-like virus infection with infectious mononucleosis. Am J Med. 1969 Oct;47(4):520–527. doi: 10.1016/0002-9343(69)90182-x. [DOI] [PubMed] [Google Scholar]
  3. Hirshaut Y., Pei D. T., Marcove R. C., Mukherji B., Spielvogel A. R., Essner E. Seroepidemiology of human sarcoma antigen (S1). N Engl J Med. 1974 Nov 21;291(21):1103–1107. doi: 10.1056/NEJM197411212912103. [DOI] [PubMed] [Google Scholar]
  4. Kasukawa R., Kano K., Bloom M. L., Milgrom F. Heterophile antibodies in pathologic human sera resembling antibodies stimulated by foreign species sera. Clin Exp Immunol. 1976 Jul;25(1):122–132. [PMC free article] [PubMed] [Google Scholar]
  5. Kitamura H., Levine P., Cheng P. J., Egeli R. A., Liu Y. P., Good R. A., Day N. K. Forssman-like antibody levels in sera of patients with lung cancer. Cancer Res. 1979 Aug;39(8):2909–2913. [PubMed] [Google Scholar]
  6. Milgrom F., Kano K., Fjelde A. Studies on heterophile antigen in lymphoma and leukemia spleens by means of absorption of infectious mononucleosis sera. Int Arch Allergy Appl Immunol. 1973;45(4):631–637. doi: 10.1159/000231106. [DOI] [PubMed] [Google Scholar]
  7. SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
  8. SOUTHAM C. M., GOLDSMITH Y., BURCHENAL J. H. Heterophile antibodies and antigens in neoplastic diseases. Cancer. 1951 Sep;4(5):1036–1042. doi: 10.1002/1097-0142(195109)4:5<1036::aid-cncr2820040521>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  9. Sethi J. K., Hirshaut Y. Variation in expression of S3 antigen in human sarcoma cell lines: influence of passages and medium on generation of S3. Eur J Cancer. 1978 Nov;14(11):1229–1235. doi: 10.1016/0014-2964(78)90229-3. [DOI] [PubMed] [Google Scholar]
  10. Sethi J., Hirshaut Y. Complement-fixing antigen of human sarcomas. J Natl Cancer Inst. 1976 Sep;57(3):489–493. doi: 10.1093/jnci/57.3.489. [DOI] [PubMed] [Google Scholar]
  11. Sethi J., Hirshaut Y., Hajdu S. I., Clements L. G. Growing human sarcomas in culture. Cancer. 1977 Aug;40(2):744–755. doi: 10.1002/1097-0142(197708)40:2<744::aid-cncr2820400223>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  12. Waldmann T. A., McIntire K. R. Serum-alpha-fetoprotein levels in patients with ataxia-telangiectasia. Lancet. 1972 Nov 25;2(7787):1112–1115. doi: 10.1016/s0140-6736(72)92717-1. [DOI] [PubMed] [Google Scholar]

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