Abstract
Polyamines, such as putrescine and spermine, are naturally occurring substances intimately associated with normal and neoplastic growth. High levels are found in cancer patients and are associated with tumour growth. Experiments with V79 hamster cells cultured in vitro have demonstrated that the presence of putrescine and spermine can significantly reduce the cytotoxicity of the commonly used chemotherapy agent cis-DDP. These data may have clinical implications.
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Selected References
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- Ben-Hur E., Riklis E. Enhancement of thermal killing by polyamines. IV. Effects of heat and spermine on protein synthesis and ornithine decarboxylase activity. Cancer Biochem Biophys. 1979;4(1):25–31. [PubMed] [Google Scholar]
- Douple E. B., Richmond R. C. A review of platinum complex biochemistry suggests a rationale for combined platinum-radiotherapy. Int J Radiat Oncol Biol Phys. 1979 Aug;5(8):1335–1339. doi: 10.1016/0360-3016(79)90665-5. [DOI] [PubMed] [Google Scholar]
- Duffy P. E., Defendini R., Kremzner L. T. Regulation of meningioma cell growth in vitro by polyamines. J Neuropathol Exp Neurol. 1971 Oct;30(4):698–713. doi: 10.1097/00005072-197110000-00012. [DOI] [PubMed] [Google Scholar]
- Durie B. G., Salmon S. E., Russell D. H. Polyamines as markers of response and disease activity in cancer chemotherapy. Cancer Res. 1977 Jan;37(1):214–221. [PubMed] [Google Scholar]
- Gerner E. W., Russell D. H. The relationship between polyamine accumulation and DNA replication in synchronized Chinese hamster ovary cells after heat shock. Cancer Res. 1977 Feb;37(2):482–489. [PubMed] [Google Scholar]
- Ham R. G. Putrescine and related amines as growth factors for a mammalian cell line. Biochem Biophys Res Commun. 1964;14:34–38. doi: 10.1016/0006-291x(63)90206-7. [DOI] [PubMed] [Google Scholar]
- Harik S. I., Sutton C. H. Putrescine as a biochemical marker of malignant brain tumors. Cancer Res. 1979 Dec;39(12):5010–5015. [PubMed] [Google Scholar]
- Hospattankar A. V., Advani S. H., Vaidya N. R., Electricwalla S. E., Braganca B. M. Elevation of serum polyamines in malignant lymphomas and acute myeloid leukemia. Int J Cancer. 1980 Apr 15;25(4):463–466. doi: 10.1002/ijc.2910250407. [DOI] [PubMed] [Google Scholar]
- O'Brien T. G., Diamond L. Ornithine decarboxylase induction and DNA synthesis in hamster embryo cell cultures treated with tumor-promoting phorbol diesters. Cancer Res. 1977 Nov;37(11):3895–3900. [PubMed] [Google Scholar]
- Rupniak H. T., Paul D. Selective killing of transformed cells by exploitation of their defective cell cycle control by polyamines. Cancer Res. 1980 Feb;40(2):293–297. [PubMed] [Google Scholar]
- Russell D. H., Durie B. G., Salmon S. E. Polyamines as predictors of success and failure in cancer chemotherapy. Lancet. 1975 Oct 25;2(7939):797–799. doi: 10.1016/s0140-6736(75)80009-2. [DOI] [PubMed] [Google Scholar]
- Russell D. H. Increased polyamine concentrations in the urine of human cancer patients. Nat New Biol. 1971 Sep 29;233(39):144–145. doi: 10.1038/newbio233144a0. [DOI] [PubMed] [Google Scholar]
- Schindler M., Koppel D. E., Sheetz M. P. Modulation of membrane protein lateral mobility by polyphosphates and polyamines. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1457–1461. doi: 10.1073/pnas.77.3.1457. [DOI] [PMC free article] [PubMed] [Google Scholar]