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. 1981 Jul;44(1):63–67. doi: 10.1038/bjc.1981.148

Terminal deoxynucleotidyl transferase activities and glucocorticoid receptors in leukaemia.

R Sasaki, F Takaku, T Aoki, F J Bollum, T Saito, S Dan
PMCID: PMC2010647  PMID: 7259961

Abstract

The relation between terminal deoxynucleotidyl transferase (TdT) activity, glucocorticoid (GC) receptors and the effect of vincristine-prednisolone (VP) therapy on fresh leukaemia cases was examined. Five of 6 TdT+ leukaemias showed high levels of GC receptors and a favourable response to VP therapy, whereas 1 acute lymphoblastic leukaemia (ALL) and 3 of chronic myelogenous leukaemia (CML) cases in blast crisis with no TdT activity showed low level of GC receptors and poor response to VP therapy. Significant correlation (r = 0.821, P less than 0.01) was observed between TdT activity and the number of GC receptor sites in these cases. X2 test showed significant difference (P less than 0.01) between TdT+ and TdT- leukaemias in the effect of VP. A significant difference (P less than 0.01) was also observed between VP-effective and ineffective leukaemias in the number of GC-receptor sites by unpaired t test. Therefore GC receptors may be responsible for the effect of VP on TdT+ leukaemias.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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