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. 1981 Jun;43(6):767–771. doi: 10.1038/bjc.1981.114

Plasma prostaglandins in mucositis due to radiotherapy and chemotherapy for head and neck cancer.

N S Tanner, I F Stamford, A Bennett
PMCID: PMC2010698  PMID: 7248158

Abstract

Patients with head and neck cancer were treated with synchronous radiotherapy and chemotherapy (vincristine, bleomycin and methotrexate). Before treatment, mucositis was absent and low amounts of prostaglandin-like material were extracted from peripheral plasma. As treatment proceeded mucositis occurred, and its degree correlated with the amount of prostaglandin-like material extracted from the plasma. Some patients were given moderate doses of drugs which inhibit prostaglandin synthesis, but mucositis still occurred.

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Selected References

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  1. Bennett A., Berry H., Osen H. E., Osen M. A. Prevention of headache with analgesics. Lancet. 1978 Jan 14;1(8055):104–104. doi: 10.1016/s0140-6736(78)90051-x. [DOI] [PubMed] [Google Scholar]
  2. Eisen V., Walker D. I. Effect of ionizing radiation on prostaglandin 15-OH-dehydrogenase (PGDH) [proceedings]. Br J Pharmacol. 1978 Mar;62(3):461P–461P. [PMC free article] [PubMed] [Google Scholar]
  3. Eisen V., Walker D. I. Effect of ionizing radiation on prostaglandin-like activity in tissues. Br J Pharmacol. 1976 Aug;57(4):527–532. doi: 10.1111/j.1476-5381.1976.tb10380.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ferreira S. H. Prostaglandins, aspirin-like drugs and analgesia. Nat New Biol. 1972 Dec 13;240(102):200–203. doi: 10.1038/newbio240200a0. [DOI] [PubMed] [Google Scholar]
  5. Ferreira S. H., Vane J. R. Prostaglandins: their disappearance from and release into the circulation. Nature. 1967 Dec 2;216(5118):868–873. doi: 10.1038/216868a0. [DOI] [PubMed] [Google Scholar]
  6. Gilmore N., Vane J. R., Wyllie J. H. Prostaglandins released by the spleen. Nature. 1968 Jun 22;218(5147):1135–1140. doi: 10.1038/2181135a0. [DOI] [PubMed] [Google Scholar]
  7. Levine L. Chemical carcinogens stimulate canine kidney (MDCK) cells to produce prostaglandins. Nature. 1977 Aug 4;268(5619):447–448. doi: 10.1038/268447a0. [DOI] [PubMed] [Google Scholar]
  8. Mennie A. T., Dalley V. M., Dinneen L. C., Collier H. O. Treatment of radiation-induced gastrointestinal distress with acetylsalicylate. Lancet. 1975 Nov 15;2(7942):942–943. doi: 10.1016/s0140-6736(75)90358-x. [DOI] [PubMed] [Google Scholar]
  9. Northway M. G., Libshitz H. I., Osborne B. M., Feldman M. S., Mamel J. J., West J. H., Szwarc I. A. Radiation esophagitis in the opossum: radioprotection with indomethacin. Gastroenterology. 1980 May;78(5 Pt 1):883–892. [PubMed] [Google Scholar]
  10. O'Connor A. D., Clifford P., Smith D. J., Edwards W., Hollis B. A., Dalley V. M. Synchronous VBM and radiotherapy in the treatment of squamous cell carcinoma of the head and neck. Clin Otolaryngol Allied Sci. 1977 Nov;2(4):347–357. doi: 10.1111/j.1365-2273.1977.tb01378.x. [DOI] [PubMed] [Google Scholar]
  11. Orton C. G., Ellis F. A simplification in the use of the NSD concept in practical radiotherapy. Br J Radiol. 1973 Jul;46(547):529–537. doi: 10.1259/0007-1285-46-547-529. [DOI] [PubMed] [Google Scholar]
  12. Stamford I. F., MacIntyre J., Bennett A. Human breast carcinomas release prostaglandin-like material into the blood. Adv Prostaglandin Thromboxane Res. 1980;6:571–573. [PubMed] [Google Scholar]
  13. Unger W. G., Stamford I. F., Bennett A. Extraction of prostaglandins from human blood. Nature. 1971 Oct 1;233(5318):336–337. doi: 10.1038/233336b0. [DOI] [PubMed] [Google Scholar]

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