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. 1981 Aug;44(2):166–176. doi: 10.1038/bjc.1981.167

Lymphocytes infiltrating human breast cancers lack K-cell activity and show low levels of NK-cell activity.

O Eremin, R R Coombs, J Ashby
PMCID: PMC2010737  PMID: 6268135

Abstract

Lymphocytes infiltrating human primary mammary carcinomas lack ADCC and show low levels of natural cytotoxicity. The peripheral blood lymphocytes, however, show a variable but prominent level of cytotoxicity. Lymphocyte preparations from breast tumours, when mixed with autologous blood lymphocytes, significantly suppress their prominent killer- (K- and NK-) cell activities.

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Selected References

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  1. Anastassiades O. T., Pryce D. M. Immunological significance of the morphological changes in lymph nodes draining breast cancer. Br J Cancer. 1966 Jun;20(2):239–249. doi: 10.1038/bjc.1966.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BERG J. W. Inflammation and prognosis in breast cancer; a search for host resistance. Cancer. 1959 Jul-Aug;12(4):714–720. doi: 10.1002/1097-0142(195907/08)12:4<714::aid-cncr2820120414>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  3. Cerottini J. C., Brunner K. T. Cell-mediated cytotoxicity, allograft rejection, and tumor immunity. Adv Immunol. 1974;18:67–132. doi: 10.1016/s0065-2776(08)60308-9. [DOI] [PubMed] [Google Scholar]
  4. Cutler S. J., Black M. M., Mork T., Harvei S., Freeman C. Further observations on prognostic factors in cancer of the female breast. Cancer. 1969 Oct;24(4):653–667. doi: 10.1002/1097-0142(196910)24:4<653::aid-cncr2820240402>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  5. Di Paola M., Angelini L., Bertolotti A., Colizza S. Host resistance in relation to survival in breast cancer. Br Med J. 1974 Nov 2;4(5939):268–270. doi: 10.1136/bmj.4.5939.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Emeson E. E. Migratory behavior of lymphocytes with specific reactivity to alloantigens. II. Selective recruitment to lymphoid cell allografts and their draining lymph nodes. J Exp Med. 1978 Jan 1;147(1):13–24. doi: 10.1084/jem.147.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Eremin O., Ashby J., Franks D. Killer cell (K) activity in human normal lymph node, regional tumour lymph node and inflammatory lymph node. Int Arch Allergy Appl Immunol. 1977;54(3):210–220. doi: 10.1159/000231829. [DOI] [PubMed] [Google Scholar]
  8. Eremin O., Ashby J., Plumb D. Antibody-dependent cellular cytotoxicity and natural cytotoxicity: effect of pre-treatment of human lymphocytes with deionised water and ammonium chloride. J Immunol Methods. 1978;24(3-4):257–267. doi: 10.1016/0022-1759(78)90130-8. [DOI] [PubMed] [Google Scholar]
  9. Eremin O., Ashby J., Stephens J. P. Human natural cytotoxicity in the blood and lymphoid organs of healthy donors and patients with malignant disease. Int J Cancer. 1978 Jan 15;21(1):35–41. doi: 10.1002/ijc.2910210108. [DOI] [PubMed] [Google Scholar]
  10. Eremin O., Coombs R. R., Plumb D., Ashby J. Characterization of the human natural killer (NK) cell in blood and lymphoid organs. Int J Cancer. 1978 Jan 15;21(1):42–50. doi: 10.1002/ijc.2910210109. [DOI] [PubMed] [Google Scholar]
  11. Eremin O., Kraft D., Coombs R. R., Franks D., Ashby J., Plumb D. Surface characteristics of the human K (killer) lymphocyte. Int Arch Allergy Appl Immunol. 1977;55(1-6):112–125. doi: 10.1159/000231917. [DOI] [PubMed] [Google Scholar]
  12. Eremin O., Plumb D., Coombs R. R. T and B lymphocyte populations in human normal lymph node, regional tumour lymph node and inflammatory lymph node. Int Arch Allergy Appl Immunol. 1976;52(1-4):277–290. doi: 10.1159/000231693. [DOI] [PubMed] [Google Scholar]
  13. Eremin O., Wilson A. B., Coombs R. R., Ashby J., Plumb D. Antibody-dependent cellular cytotoxicity in the guinea pig: the role of the Kurloff cell. Cell Immunol. 1980 Oct;55(2):312–327. doi: 10.1016/0008-8749(80)90164-1. [DOI] [PubMed] [Google Scholar]
  14. Hamlin I. M. Possible host resistance in carcinoma of the breast: a histological study. Br J Cancer. 1968 Sep;22(3):383–401. doi: 10.1038/bjc.1968.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Haskill S., Parthenais E. Immunologic factors influencing the intra-tumor localization of ADCC effector cells. J Immunol. 1978 Jun;120(6):1813–1817. [PubMed] [Google Scholar]
  16. Herberman R. B., Holden H. T. Natural killer cells as antitumor effector cells. J Natl Cancer Inst. 1979 Mar;62(3):441–445. doi: 10.1093/jnci/62.3.441. [DOI] [PubMed] [Google Scholar]
  17. Kanski A., Spencer J., Eremin O. Sephadex G-10 columns do not retain selectively T or B lymphocyte subpopulations. J Immunol Methods. 1981;42(2):147–156. doi: 10.1016/0022-1759(81)90144-7. [DOI] [PubMed] [Google Scholar]
  18. Moore K., Moore M. Systemic and in-situ natural killer activity in tumour-bearing rats. Br J Cancer. 1979 Jun;39(6):636–647. doi: 10.1038/bjc.1979.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Ortaldo J. R., Oldham R. K., Cannon G. C., Herberman R. B. Specificity of natural cytotoxic reactivity of normal human lymphocytes against a myeloid leukemia cell line. J Natl Cancer Inst. 1977 Jul;59(1):77–82. doi: 10.1093/jnci/59.1.77. [DOI] [PubMed] [Google Scholar]
  20. Osband M., Parkman R. The control of autoreactivity. I. Lack of autoreactivity in murine spleens is due to concomitant presence of suppressor and autocytotoxic lymphocytes. J Immunol. 1978 Jul;121(1):179–185. [PubMed] [Google Scholar]
  21. Parkman R., Rosen F. S. Identification of a subpopulation of lymphocytes in human peripheral blood cytotoxic to autologous fibroblasts. J Exp Med. 1976 Dec 1;144(6):1520–1530. doi: 10.1084/jem.144.6.1520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Radov L. A., Haskill J. S., Korn J. H., Fett J. W. Correlation between tumor-specific systemic and in situ immunity as manifested by the delayed hypersensitivity response. J Natl Cancer Inst. 1979 Jan;62(1):103–108. [PubMed] [Google Scholar]
  23. Underwood J. C. Lymphoreticular infiltration in human tumours: prognostic and biological implications: a review. Br J Cancer. 1974 Dec;30(6):538–548. doi: 10.1038/bjc.1974.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Vose B. M., Moore M. Natural cytotoxicity in humans: susceptibility of freshly isolatd tumor cells to lysis. J Natl Cancer Inst. 1980 Aug;65(2):257–263. [PubMed] [Google Scholar]
  25. Vose B. M., Moore M. Suppressor cell activity of lymphocytes infiltrating human lung and breast tumours. Int J Cancer. 1979 Nov 15;24(5):579–585. doi: 10.1002/ijc.2910240510. [DOI] [PubMed] [Google Scholar]
  26. Vose B. M., Vánky F., Klein E. Human tumour--lymphocyte interaction in vitro. V. Comparison of the reactivity of tumour-infiltrating, blood and lymph-node lymphocytes with autologous tumour cells. Int J Cancer. 1977 Dec 15;20(6):895–902. doi: 10.1002/ijc.2910200612. [DOI] [PubMed] [Google Scholar]

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