Abstract
A randomized trial comparing routine follow-up with a treatment regimen aimed at increasing specific anti-tumour immunity has been carried out in 95 patients after total surgical excision of lung cancer (not small-cell). Treatment consisted of inoculation with an autologous irradiated suspension of tumour cells combined with a small dose of C. parvum given intradermally during convalescence. Although treatment was associated with virtually no side effects, there has been no apparent benefit and input to the trial has now stopped.
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Selected References
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- BLACK M. M., SPEER F. D. Sinus histiocytosis of lymph nodes in cancer. Surg Gynecol Obstet. 1958 Feb;106(2):163–175. [PubMed] [Google Scholar]
- Bomford R. Active specific immunotherapy of mouse methylcholanthrene induced tumours with Corynebacterium parvum and irradiated tumour cells. Br J Cancer. 1975 Nov;32(5):551–557. doi: 10.1038/bjc.1975.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eilber F. R., Morton D. L., Holmes E. C., Sparks F. C., Ramming K. P. Adjuvant immunotherapy with BCG in treatment of regional-lymph-node metastases from malignant melanoma. N Engl J Med. 1976 Jan 29;294(5):237–240. doi: 10.1056/NEJM197601292940501. [DOI] [PubMed] [Google Scholar]
- Herlyn D., Herlyn M., Steplewski Z., Koprowski H. Monoclonal antibodies in cell-mediated cytotoxicity against human melanoma and colorectal carcinoma. Eur J Immunol. 1979 Aug;9(8):657–659. doi: 10.1002/eji.1830090817. [DOI] [PubMed] [Google Scholar]
- Israel L., Mugica J., Chahinian P. Prognosis of early bronchogenic carcinoma. Survival curves of 451 patients after resection of lung cancer in relation to the results of pre-operative tuberculin skin test. Biomedicine. 1973 Feb 10;19(2):68–72. [PubMed] [Google Scholar]
- Matthews M. J., Kanhouwa S., Pickren J., Robinette D. Frequency of residual and metastatic tumor in patients undergoing curative surgical resection for lung cancer. Cancer Chemother Rep 3. 1973 Mar;4(2):63–67. [PubMed] [Google Scholar]
- McIllmurray M. B., Embleton M. J., Reeves W. G., Langman M. J., Deane M. Controlled trial of active immunotherapy in management of stage IIB malignant melanoma. Br Med J. 1977 Feb 26;1(6060):540–542. doi: 10.1136/bmj.1.6060.540. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McKneally M. F., Maver C., Kausel H. W. Regional immunotherapy of lung cancer with intrapleural B.C.G. Lancet. 1976 Feb 21;1(7956):377–379. doi: 10.1016/s0140-6736(76)90212-9. [DOI] [PubMed] [Google Scholar]
- Mikulski S. M., McGuire W. P., Louie A. C., Chirigos M. A., Muggia F. M. Immunotherapy of lung cancer. I. Review of clinical trials in non-small cell histologic types. Cancer Treat Rev. 1979 Sep;6(3):177–190. doi: 10.1016/s0305-7372(79)80069-9. [DOI] [PubMed] [Google Scholar]
- PREHN R. T., MAIN J. M. Immunity to methylcholanthrene-induced sarcomas. J Natl Cancer Inst. 1957 Jun;18(6):769–778. [PubMed] [Google Scholar]
- Proctor J., Rudenstam C. M., Alexander P. Increased incidence of lung metastases following treatment of rats bearing hepatomas with irradiated tumour cells and the benefical effect of Corynebacterium parvum in this system. Biomedicine. 1973 Jun 20;19(6):248–252. [PubMed] [Google Scholar]
- Scott M. T. Corynebacterium parvum as a therapeutic antitumor agent in mice. II. Local injection. J Natl Cancer Inst. 1974 Sep;53(3):861–865. doi: 10.1093/jnci/53.3.861. [DOI] [PubMed] [Google Scholar]
- Stewart T. H. The presence of delayed hypersensitivity reactions in patients toward cellular extracts of their malignant tumors. 2. A correlation between the histologic picture of lymphocyte infiltration of the tumor stroma, the presence of such a reaction, and a discussion of the significance of this phenomenon. Cancer. 1969 Jun;23(6):1380–1387. doi: 10.1002/1097-0142(196906)23:6<1380::aid-cncr2820230620>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
- Stott H., Stephens R. J., Fox W., Roy D. C. 5-year follow-up of cytotoxic chemotherapy as an adjuvant to surgery in carcinoma of the bronchus. Br J Cancer. 1976 Aug;34(2):167–173. doi: 10.1038/bjc.1976.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woodruff M. F., Ghaffar A., Dunbar N., Whitehead V. L. Effect of C. Parvum on immunization with irradiated tumour cells. Br J Cancer. 1976 May;33(5):491–495. doi: 10.1038/bjc.1976.79. [DOI] [PMC free article] [PubMed] [Google Scholar]
