Abstract
Twentynine children with non-Hodgkin's lymphomas (NHL) were treated between 1974 and 1977 with a protocol based on those used for childhood ALL. 76% of patients had advanced disease by Ann Arbor criteria. All tumours had Rappaport's diffuse histology. 19 patients (65%) achieved complete remission, 14 (65%) remained alive and disease free beyond 42 months from diagnosis. 10 patients failed to enter complete remission, of whom all died. 7 patients relapsed; 5 died, 2 remain disease free and off treatment at 19 and 29 months. Comparison with a historic group of 20 consecutively treated children shows improved survival (P less than 0.01). 18 controls died. Histology was reviewed using the Kiel classification and staging according to Murphy's criteria. These are compared with the methods used initially. The improved outlook for children with NHL using intensive multiple drug regimes and cranial prophylaxis is confirmed. In staging childhood NHL, Murphy's criteria, which take into account the natural history of the disease, have greater prognosis value. Histology and pattern of outcome of the disease suggest basic differences between primary abdominal and primary mediastinal and nodal disease. This is now being confirmed with immunological typing and will be reflected in the development of future protocols.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aur R. J., Hustu H. O., Simone J. V., Pratt C. B., Pinkel D. Therapy of localized and regional lymphosarcoma of childhood. Cancer. 1971 Jun;27(6):1328–1331. doi: 10.1002/1097-0142(197106)27:6<1328::aid-cncr2820270608>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
- Brecher M. L., Sinks L. F., Thomas R. R., Freeman A. I. Non-Hodgkin's lymphoma in children. Cancer. 1978 May;41(5):1997–2001. doi: 10.1002/1097-0142(197805)41:5<1997::aid-cncr2820410546>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
- Carabell S. C., Cassady J. R., Weinstein H. J., Jaffe N. The role of radiation therapy in the treatment of pediatric non-Hodgkin's lymphomas. Cancer. 1978 Nov;42(5):2193–2205. doi: 10.1002/1097-0142(197811)42:5<2193::aid-cncr2820420517>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
- Murphy S. B. Classification, staging and end results of treatment of childhood non-Hodgkin's lymphomas: dissimilarities from lymphomas in adults. Semin Oncol. 1980 Sep;7(3):332–339. [PubMed] [Google Scholar]
- Murphy S. B., Hustu H. O. A randomized trial of combined modality therapy of childhood non-Hodgkin's lymphoma. Cancer. 1980 Feb 15;45(4):630–637. doi: 10.1002/1097-0142(19800215)45:4<630::aid-cncr2820450403>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
- Wollner N., Exelby P. R., Lieberman P. H. Non-Hodgkin's lymphoma in children: a progress report on the original patients treated with the LSA2-L2 protocol. Cancer. 1979 Dec;44(6):1990–1999. doi: 10.1002/1097-0142(197912)44:6<1990::aid-cncr2820440605>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]