Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1982 Feb;45(2):265–271. doi: 10.1038/bjc.1982.42

Differential effect of hyperthermia and x-irradiation on regrowth rate and tumour-bed effect for a rat sarcoma.

T E Wheldon, E C Hingston
PMCID: PMC2010887  PMID: 7059475

Abstract

The regrowth rate of the rat sarcoma SSB1a was assessed, following treatment with either X-rays or hyperthermia. The growth rate of untreated tumours implanted in pre-irradiated or pre-heated normal tissue was also measured. For treatments giving similar levels of tumour regrowth delay, the regrowth of irradiated tumours was markedly slower than that of untreated tumours, whilst the regrowth rate of tumours subjected to hyperthermia did not differ from that of untreated tumours. The growth rate of untreated tumours implanted in pre-irradiated skin was also slower than that of control tumours, though the growth-rate reduction was less dramatic than for regrowth following tumour irradiation in situ. Tumours implanted in pre-heated skin grew at the same rate as control tumours. Slower regrowth in situ after X-rays than after hyperthermia would produce a larger growth delay for X-rays than for hyperthermia, for equal levels of tumour-cell kill or probability of tumour sterilization. This effect could lead to a systematic underestimation of the efficacy of hyperthermia relative to X-rays, when efficacy is assessed by growth delay.

Full text

PDF
265

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abdelaal A. S., Wheldon T. E., Clarke B. M. Perturbation of the growth kinetics of C3H mouse mammary carcinoma by irradiation of tumour and host and by attempted pre-immunization of host. Br J Cancer. 1980 Apr;41(4):567–576. doi: 10.1038/bjc.1980.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Breur K. Growth rate and radiosensitivity of human tumours. I. Growth rate of human tumours. Eur J Cancer. 1966 Jun;2(2):157–171. doi: 10.1016/0014-2964(66)90008-9. [DOI] [PubMed] [Google Scholar]
  3. Brown J. M., Howes A. E. Letter: Comparison of tumour growth delay with cell survival. Br J Radiol. 1974 Aug;47(560):509–510. doi: 10.1259/0007-1285-47-560-509. [DOI] [PubMed] [Google Scholar]
  4. Clifton K. H., Jirtle R. Mammary carcinoma cell population growth in preirradiated and unirradiated transplant sites. Viable tumor growth, vascularity, and the tumor-bed effect. Radiology. 1975 Nov;117(2):459–465. doi: 10.1148/117.2.459. [DOI] [PubMed] [Google Scholar]
  5. Falk P. The vascular pattern of the spontaneous C3H mouse mammary carcinoma and its significance in radiation response and in hyperthermia. Eur J Cancer. 1980 Feb;16(2):203–217. doi: 10.1016/0014-2964(80)90152-8. [DOI] [PubMed] [Google Scholar]
  6. Hawkes M. J., Hill R. P., Lindp P. J., Ellis R. E., Rotblat J. R. The response of C3H mammary tumours to irradiation in single and fractionated doses. Br J Radiol. 1968 Feb;41(482):134–141. doi: 10.1259/0007-1285-41-482-134. [DOI] [PubMed] [Google Scholar]
  7. Hewitt H. B., Blake E. R. The growth of transplanted murine tumours in pre-irradiated sites. Br J Cancer. 1968 Dec;22(4):808–824. doi: 10.1038/bjc.1968.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Howlett J. F., Thomlinson R. H., Alper T. A marked dependence of the comparative effectiveness of neutrons on tumour line, and its implications for clinical trials. Br J Radiol. 1975 Jan;48(565):40–47. doi: 10.1259/0007-1285-48-565-40. [DOI] [PubMed] [Google Scholar]
  9. Jirtle R., Rankin J. H., Clifton K. H. Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs. Br J Cancer. 1978 Jun;37(6):1033–1038. doi: 10.1038/bjc.1978.150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. McNally N. J. Letter: Tumour growth delay and cell survival "in situ". Br J Radiol. 1974 Aug;47(560):510–511. doi: 10.1259/0007-1285-47-560-510. [DOI] [PubMed] [Google Scholar]
  11. Peacock J. H., Stephens T. C. Influence of anaesthetics on tumour-cell kill and repopulation in B16 melanoma treated with melphalan. Br J Cancer. 1978 Dec;38(6):725–731. doi: 10.1038/bjc.1978.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. STENSTROM K. W., VERMUND H., MOSSER D. G., MARVIN J. F. Effects of roentgen irradiation on the tumor bed. I. The inhibiting action of local pretransplantation roentgen irradiation (1500 r alpha) on the growth of mouse mammary carcinoma. Radiat Res. 1955 Apr;2(2):180–191. [PubMed] [Google Scholar]
  13. SUIT H. D., SHALEK R. J. RESPONSE OF ANOXIC C3H MOUSE MAMMARY CARCINOMA ISOTRANSPLANTS (1-25 MM3) TO X IRRADIATION. J Natl Cancer Inst. 1963 Sep;31:479–495. [PubMed] [Google Scholar]
  14. SUMMERS W. C., CLIFTON K. H., VERMUND H. X-IRRADIATION OF THE TUMOR BED. I. A STUDY OF THE INDIRECT ACTIONS OF RADIATION ON TRANSPLANTABLE TUMORS. Radiology. 1964 Apr;82:691–703. doi: 10.1148/82.4.691. [DOI] [PubMed] [Google Scholar]
  15. Song C. W., Kang M. S., Rhee J. G., Levitt S. H. Vascular damage and delayed cell death in tumours after hyperthermia. Br J Cancer. 1980 Feb;41(2):309–312. doi: 10.1038/bjc.1980.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Stephens T. C., Peacock J. H. Tumour volume response, initial cell kill and cellular repopulation in B16 melanoma treated with cyclophosphamide and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. Br J Cancer. 1977 Sep;36(3):313–321. doi: 10.1038/bjc.1977.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Thomlinson R. H., Craddock E. A. The gross response of an experimental tumour to single doses of x-rays. Br J Cancer. 1967 Mar;21(1):108–123. doi: 10.1038/bjc.1967.10. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Urano M., Cunningham M. Insignificant tumor bed effect after pretransplantation hyperthermia. Cancer Res. 1980 Jan;40(1):26–28. [PubMed] [Google Scholar]
  19. Urano M., Suit H. D. Experimental evaluation of tumor bed effect for C3H mouse mammary carcinoma and for C3H mouse fibrosarcoma. Radiat Res. 1971 Jan;45(1):41–49. [PubMed] [Google Scholar]
  20. Wheldon T. E. Can dose-survival parameters be deduced from in situ assays? Br J Cancer Suppl. 1980 Apr;4:79–87. [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES