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. 1982 Mar;45(3):384–389. doi: 10.1038/bjc.1982.65

Peripheral plasma immunoreactive 6-oxo-prostaglandin F1 alpha and gynaecological tumours.

M Alam, M Jogee, W G MacGregor, J W Dowdell, M G Elder, L Myatt
PMCID: PMC2010920  PMID: 6896152

Abstract

Peripheral plasma levels of immunoreactive 6-oxo-PGF1 alpha, the stable hydrolysis product of prostacyclin, were significantly higher in female patients with tumours of the genital tract than in normal controls. In the groups with malignant tumours, these high levels declined after operation and/or radiotherapy if the tumour responded to treatment. In patients who did not respond to treatment or with tumour recurrence, levels of plasma 6-oxo-PGF1 alpha remained high or even rose further. Benign gynaecological tumours were also associated with significantly raised plasma 6-oxo-PGF1 alpha levels, and these fell to normal levels immediately on surgical removal of the tumour. Possible reasons for these alterations are described. Further investigations are warranted to see whether serial measurements of plasma 6-oxo-PGF1 alpha could be used as a prognostic index for the clinical status of patients with gynaecological tumours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett A., McDonald A. M., Simpson J. S., Stamford I. F. Breast cancer, prostaglandins, and bone metastases. Lancet. 1975 May 31;1(7918):1218–1220. doi: 10.1016/s0140-6736(75)92197-2. [DOI] [PubMed] [Google Scholar]
  2. Cummings K. B., Robertson R. P. Prostaglandin: increased production by renal cell carcinoma. J Urol. 1977 Nov;118(5):720–723. doi: 10.1016/s0022-5347(17)58172-0. [DOI] [PubMed] [Google Scholar]
  3. Hawkings H. J., Smith J. B., Nicolaou K. C., Eling T. E. Studies of the mechanisms involved in the fate of prostacyclin (PGI2) and 6-keto-PGF1alpha in the pulmonary circulation. Prostaglandins. 1978 Dec;16(6):871–884. doi: 10.1016/0090-6980(78)90103-x. [DOI] [PubMed] [Google Scholar]
  4. Mortel R., Allegra J. C., Demers L. M., Harvey H. A., Trautlein J., Nahhas W., White D., Gillin M. A., Lipton A. Plasma prostaglandins across the tumor bed of patients with gynecologic malignancy. Cancer. 1977 May;39(5):2201–2203. doi: 10.1002/1097-0142(197705)39:5<2201::aid-cncr2820390538>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  5. Powles T. J., Coombes R. C., Neville A. M., Ford H. T., Gazet J. C., Levine L. 15-keto-13,14-dihydroprostaglandin E2 concentrations in serum of patients with breast cancer. Lancet. 1977 Jul 16;2(8029):138–138. doi: 10.1016/s0140-6736(77)90146-5. [DOI] [PubMed] [Google Scholar]
  6. Rolland P. H., Martin P. M., Jacquemier J., Rolland A. M., Toga M. Prostaglandin in human breast cancer: Evidence suggesting that an elevated prostaglandin production is a marker of high metastatic potential for neoplastic cells. J Natl Cancer Inst. 1980 May;64(5):1061–1070. [PubMed] [Google Scholar]
  7. Sanders R. R., Lee W. H., Koh L., Brennecke A., Jones W. R. Plasma prostaglandin F levels and malignant tumours of the female genital tract. Br J Obstet Gynaecol. 1980 Feb;87(2):139–141. doi: 10.1111/j.1471-0528.1980.tb04507.x. [DOI] [PubMed] [Google Scholar]
  8. Sandler M., Karim S. M., Williams E. D. Prostaglandins in amine-peptide-secreting tumours. Lancet. 1968 Nov 16;2(7577):1053–1054. doi: 10.1016/s0140-6736(68)91528-6. [DOI] [PubMed] [Google Scholar]
  9. Singh E. J., Baccarini I., Zuspan F. P. Levels of prostaglandins F-2alpha and E-2 in human endometrium during the menstrual cycle. Am J Obstet Gynecol. 1975 Apr 1;121(7):1003–1006. doi: 10.1016/0002-9378(75)90927-8. [DOI] [PubMed] [Google Scholar]
  10. Stamford I. F., MacIntyre J., Bennett A. Human breast carcinomas release prostaglandin-like material into the blood. Adv Prostaglandin Thromboxane Res. 1980;6:571–573. [PubMed] [Google Scholar]
  11. Tanner N. S., Stamford I. F., Bennett A. Plasma prostaglandins in mucositis due to radiotherapy and chemotherapy for head and neck cancer. Br J Cancer. 1981 Jun;43(6):767–771. doi: 10.1038/bjc.1981.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Williams E. D., Karim S. M., Sandler M. Prostaglandin secretion by medullary carcinoma of the thyroid. A possible cause of the associated idarrhoea. Lancet. 1968 Jan 6;1(7532):22–23. doi: 10.1016/s0140-6736(68)90010-x. [DOI] [PubMed] [Google Scholar]
  13. Willman E. A., Collins W. P., Clayton S. G. Studies in the involvement of prostaglandins in uterine symptomatology and pathology. Br J Obstet Gynaecol. 1976 May;83(5):337–341. doi: 10.1111/j.1471-0528.1976.tb00839.x. [DOI] [PubMed] [Google Scholar]

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