Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1982 Mar;45(3):421–428. doi: 10.1038/bjc.1982.70

Renal and haemopoietic proliferative defects as a delayed consequence of cis-platin, adriamycin and daunomycin treatments.

P G Braunschweiger, C J Kovacs, L L Schenken
PMCID: PMC2010941  PMID: 7200368

Abstract

The long-term effects of Adriamycin (ADR), daunomycin (DMN) and cis-dichlorodiammine platinum (II) (DDP) on the ability of murine renal tubular epithelium and erythropoiesis to respond to an acute proliferative stress was investigated. Folic acid (FA) and acute anaemia induced by bleeding were used as acute proliferative stimuli for renal-tubule epithelium and erythropoiesis respectively. The ability of these normal cell-renewal systems to mount a regenerative proliferative response was evaluated by radioisotopic, morphological and gravimetric techniques 4 months after drug treatment. The results indicate that pretreatment with these agents produce a long-lasting reduction in the ability of these cell-renewal systems to mount regenerative proliferation. In the kidney, the ability to respond to FA was most severely compromised by ADR and DDP, whereas in the erythropoietic system all 3 agents induced a long-lasting proliferative defect.

Full text

PDF
421

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arneil G. C., Harris F., Emmanuel I. G., Young D. G., Flatman G. E., Zachary R. B. Nephritis in two children after irradiation and chemotherapy for nephroblastoma. Lancet. 1974 May 18;1(7864):960–963. doi: 10.1016/s0140-6736(74)91264-1. [DOI] [PubMed] [Google Scholar]
  2. Bobrow S. N., Jaffe E., Young R. C. Anuria and acute tubular necrosis associated with gentamicin and cephalothin. JAMA. 1972 Dec 18;222(12):1546–1547. [PubMed] [Google Scholar]
  3. Botnick L. E., Hannon E. C., Hellman S. Multisystem stem cell failure after apparent recovery from alkylating agents. Cancer Res. 1978 Jul;38(7):1942–1947. [PubMed] [Google Scholar]
  4. Braunschweiger P. G., Schenken L. L., Schiffer L. M. Adriamycin-induced delayed erythropoietic injury expressed following anemia stress. Cancer Res. 1980 Jul;40(7):2257–2262. [PubMed] [Google Scholar]
  5. Byrnes K. A., Ghidoni J. J., Mayfield E. D., Jr Response of the rat kidney to folic acid administration. I. Biochemical studies. Lab Invest. 1972 Feb;26(2):184–190. [PubMed] [Google Scholar]
  6. Byrnes K. A., Ghidoni J. J., Suzuki M., Thomas H., Mayfield E. D., Jr Response of the rat kidney to folic acid administration. II. Morphologic studies. Lab Invest. 1972 Feb;26(2):191–200. [PubMed] [Google Scholar]
  7. Dentino M., Luft F. C., Yum M. N., Williams S. D., Einhorn L. H. Long term effect of cis-diamminedichloride platinum (CDDP) on renal function and structure in man. Cancer. 1978 Apr;41(4):1274–1281. doi: 10.1002/1097-0142(197804)41:4<1274::aid-cncr2820410410>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  8. Donaldson S. S., Moskowitz P. S., Canty E. L., Efron B. Radiation-induced inhibition of compensatory renal growth in the weanling mouse kidney. Radiology. 1978 Aug;128(2):491–495. doi: 10.1148/128.2.491. [DOI] [PubMed] [Google Scholar]
  9. Freeman A. I., Ettinger L. J., Brecher M. L. cis-Dichlorodiammineplatinum(II) in childhood cancer. Cancer Treat Rep. 1979 Sep-Oct;63(9-10):1615–1620. [PubMed] [Google Scholar]
  10. Gong J. K., MacVittie T. J., Vertalino J. E. A method for determining residual injury in the hematopoietic system of the x-irradiated rat. Radiat Res. 1969 Mar;37(3):467–477. [PubMed] [Google Scholar]
  11. Kovacs C. J., Braunschweiger P. G., Schenken L. L., Burholt D. R. Proliferative defects in renal and intestinal epithelium after cis-dichlorodiammine platinum (II). Br J Cancer. 1982 Feb;45(2):286–294. doi: 10.1038/bjc.1982.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Litterst C. L., LeRoy A. F., Guarino A. M. Disposition and distribution of platinum following parenteral administration of cis-dichlorodiammineplatinum(II) to animals. Cancer Treat Rep. 1979 Sep-Oct;63(9-10):1485–1492. [PubMed] [Google Scholar]
  13. Lohrmann H. P., Schreml W., Lang M., Betzler M., Fliedner T. M., Heimpel H. Changes of granulopoiesis during and after adjuvant chemotherapy of breast cancer. Br J Haematol. 1978 Nov;40(3):369–381. doi: 10.1111/j.1365-2141.1978.tb05808.x. [DOI] [PubMed] [Google Scholar]
  14. Mayer E. G., Poulter C. A., Aristizabal S. A. Complications of irradiation related to apparent drug potentiation by adriamycin. Int J Radiat Oncol Biol Phys. 1976 Nov-Dec;1(11-12):1179–1188. doi: 10.1016/0360-3016(76)90091-2. [DOI] [PubMed] [Google Scholar]
  15. Moskowitz P. S., Donaldson S. S., Canty E. John Caffey Award: chemotherapy-induced inhibition of compensatory renal growth in the immature mouse. AJR Am J Roentgenol. 1980 Mar;134(3):491–496. doi: 10.2214/ajr.134.3.491. [DOI] [PubMed] [Google Scholar]
  16. Nygaard K., Smith-Erichsen N., Hatlevoll R., Refsum S. B. Pulmonary complications after bleomycin, irradiation and surgery for esophageal cancer. Cancer. 1978 Jan;41(1):17–22. doi: 10.1002/1097-0142(197801)41:1<17::aid-cncr2820410105>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  17. Phillips T. L., Fu K. K. Quantification of combined radiation therapy and chemotherapy effects on critical normal tissues. Cancer. 1976 Feb;37(2 Suppl):1186–1200. doi: 10.1002/1097-0142(197602)37:2+<1186::aid-cncr2820370830>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  18. Ransom J. L., Novak R. W., Kumar A. P., Hustu H. O., Pratt C. B. Delayed gastrointestinal complications after combined modality therapy of childhood rhabdomyosarcoma. Int J Radiat Oncol Biol Phys. 1979 Aug;5(8):1275–1279. doi: 10.1016/0360-3016(79)90653-9. [DOI] [PubMed] [Google Scholar]
  19. Razek A., Valeriote F., Vietti T. Survival of hematopoietic and leukemic colony-forming cells in vivo following the administration of daunorubicin or adriamycin. Cancer Res. 1972 Jul;32(7):1496–1500. [PubMed] [Google Scholar]
  20. Resnick M. I., Albert D. J., Persky L. Inhibition of compensatory renal hypertrophy with mithramycin. J Urol. 1972 Aug;108(2):194–196. doi: 10.1016/s0022-5347(17)60685-2. [DOI] [PubMed] [Google Scholar]
  21. Schenken L. L., Burholt D. R., Kovacs C. J. Adriamycin-radiation combinations: drug induced relayed gastrointestinal radiosensitivity. Int J Radiat Oncol Biol Phys. 1979 Aug;5(8):1265–1269. doi: 10.1016/0360-3016(79)90651-5. [DOI] [PubMed] [Google Scholar]
  22. Siemann D. W., Sutherland R. M. A comparison of the pharmacokinetics of multiple and single dose administrations of adriamycin. Int J Radiat Oncol Biol Phys. 1979 Aug;5(8):1271–1274. doi: 10.1016/0360-3016(79)90652-7. [DOI] [PubMed] [Google Scholar]
  23. Sternberg S. S. Cross-striated fibrils and other ultrastructural alterations in glomeruli of rats with daunomycin nephrosis. Lab Invest. 1970 Jul;23(1):39–51. [PubMed] [Google Scholar]
  24. Taylor D. M., Tew K. D., Jones J. D. Effects of cis-dichlorodiammine platinum (II) on DNA synthesis in kidney and other tissues of normal and tumour-bearing rats. Eur J Cancer. 1976 Apr;12(4):249–254. doi: 10.1016/0014-2964(76)90103-1. [DOI] [PubMed] [Google Scholar]
  25. Taylor D. M., Threlfall G., Buck A. T. Stimulation of renal growth in the rat by folic acid. Nature. 1966 Oct 29;212(5061):472–474. doi: 10.1038/212472a0. [DOI] [PubMed] [Google Scholar]
  26. Tefft M., Lattin P. B., Jereb B., Cham W., Ghavimi G., Rosen G., Exelby P., Marcove R., Murphy M. L., D'Angio G. J. Acute and late effects on normal tissues following combined chemo- and radiotherapy for childhood rhabdomyosarcoma and Ewing's sarcoma. Cancer. 1976 Feb;37(2 Suppl):1201–1217. doi: 10.1002/1097-0142(197602)37:2+<1201::aid-cncr2820370831>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  27. Threlfall G., Taylor D. M., Buck A. T. Studies of the changes in growth and DNA synthesis in the rat kidney during experimentally induced renal hypertrophy. Am J Pathol. 1967 Jan;50(1):1–14. [PMC free article] [PubMed] [Google Scholar]
  28. Threlfall G., Taylor D. M., Buck A. T. The effect of folic acid on growth and deoxyribonucleic acid synthesis in the rat kidney. Lab Invest. 1966 Sep;15(9):1477–1485. [PubMed] [Google Scholar]
  29. Yesair D. W., Schwartzbach E., Shuck D., Denine E. P., Asbell M. A. Comparative pharmacokinetics of daunomycin and adriamycin in several animal species. Cancer Res. 1972 Jun;32(6):1177–1183. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES