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. 1982 Apr;45(4):531–542. doi: 10.1038/bjc.1982.89

Establishment and characterization of human neuroblastoma and ganglioneuroblastoma cell lines.

L J Morrison, A J Cochran, A A Gibson, M L Willoughby, I A More
PMCID: PMC2010984  PMID: 7073944

Abstract

The establishment in culture and characterization of 4 human neuroblastoma (NB) cell lines and 1 human ganglioneuroblastoma cell line are described. Each cell line fulfilled at least 2 of 4 criteria for malignant or transformed cells: viz., subcultured more than 70 times, high saturation density with absence of contact inhibition, population-doubling time within a range of 10-40 h, and tumour formation in nu/nu mice. Each cell line also fulfilled at least 2 of 3 criteria for neuroblastoma cells: viz., humoral and cell-mediated immune reactivity toward NB-associated cell-surface antigen, intracellular storage and extra-cellular secretion of catecholamines, and characteristic neuroblast and ganglion-cell morphology.

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These references are in PubMed. This may not be the complete list of references from this article.

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