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. 1982 May;45(5):762–768. doi: 10.1038/bjc.1982.118

Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy.

A Bennett, D A Berstock, M A Carroll
PMCID: PMC2011006  PMID: 7082558

Abstract

In mice with a transplantable mammary carcinoma, treatment with the prostaglandin-synthesis inhibitors flurbiprofen or indomethacin produced various beneficial effects. Survival time after excision of the transplanted tumour was increase, particularly when the drugs were given with the chemotherapeutic agents methrotrexate and melphalan, and there were more disease-free survivors. The combined treatment with flurbiprofen also gave less tumour recurrence at the excision site. Flurbiprofen did not seem to alter the bioavailability of the chemotherapeutic agents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett A., Houghton J., Leaper D. J., Stamford I. F. Cancer growth, response to treatment and survival time in mice: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen. Prostaglandins. 1979 Feb;17(2):179–191. doi: 10.1016/0090-6980(79)90037-6. [DOI] [PubMed] [Google Scholar]
  2. Bennett A., Houghton J., Leaper D. J., Stamford I. F. Tumour growth and response to treatment: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen [proceedings]. Br J Pharmacol. 1978 Jun;63(2):356P–357P. [PMC free article] [PubMed] [Google Scholar]
  3. Bennett A., Stamford I. F., Unger W. G. Prostaglandin E2 and gastric acid secretion in man. J Physiol. 1973 Mar;229(2):349–360. doi: 10.1113/jphysiol.1973.sp010142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Berstock D. A., Frank G. J., Stamford I. F., Bennett A. Decrease in aspirin-induced gastric mucosal damage in rats by oral administration of the cytotoxic drugs melphalan and methotrexate. J Pharm Pharmacol. 1980 Aug;32(8):544–546. doi: 10.1111/j.2042-7158.1980.tb12992.x. [DOI] [PubMed] [Google Scholar]
  5. Berstock D. A., Houghton J., Bennett A. Improved anticancer effect by combining cytotoxic drugs with an inhibitor of prostaglandin synthesis. Cancer Treat Rev. 1979 Jun;6 (Suppl):69–71. doi: 10.1016/s0305-7372(79)80015-8. [DOI] [PubMed] [Google Scholar]
  6. Favalli C., Garaci E., Etheredge E., Santoro M. G., Jaffe B. M. Influence of PGE on the immune response in melanoma-bearing mice. J Immunol. 1980 Aug;125(2):897–902. [PubMed] [Google Scholar]
  7. Gasic G. J., Gasic T. B., Galanti N., Johnson T., Murphy S. Platelet-tumor-cell interactions in mice. The role of platelets in the spread of malignant disease. Int J Cancer. 1973 May;11(3):704–718. doi: 10.1002/ijc.2910110322. [DOI] [PubMed] [Google Scholar]
  8. Gryglewski R. J., Panczenko B., Korbut R., Grodzinska L., Ocetkiewicz A. Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig. Prostaglandins. 1975 Aug;10(2):343–355. doi: 10.1016/0090-6980(75)90053-2. [DOI] [PubMed] [Google Scholar]
  9. Hewitt H. B., Blake E. R., Walder A. S. A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin. Br J Cancer. 1976 Mar;33(3):241–259. doi: 10.1038/bjc.1976.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Higgs G. A., Eakins K. E., Mugridge K. G., Moncada S., Vane J. R. The effects of non-steroid anti-inflammatory drugs on leukocyte migration in carrageenin-induced inflammation. Eur J Pharmacol. 1980 Aug 22;66(1):81–86. doi: 10.1016/0014-2999(80)90297-6. [DOI] [PubMed] [Google Scholar]
  11. Hofer D., Dubitsky A. M., Reïlly P., Santoro M. G., Jaffe B. M. The interactions between indomethacin and cytotoxic drugs in mice bearing B-16 melanomas. Prostaglandins. 1980 Dec;20(6):1033–1038. doi: 10.1016/0090-6980(80)90057-x. [DOI] [PubMed] [Google Scholar]
  12. Leaper D. J., French B. T., Bennett A. Breast cancer and prostaglandins: a new approach to treatment. Br J Surg. 1979 Oct;66(10):683–686. doi: 10.1002/bjs.1800661004. [DOI] [PubMed] [Google Scholar]
  13. Lee E. T., Desu M. M. A computer program for comparing K samples with right-censored data. Comput Programs Biomed. 1972 Nov;2(4):315–321. doi: 10.1016/0010-468x(72)90019-0. [DOI] [PubMed] [Google Scholar]
  14. Lynch N. R., Castes M., Astoin M., Salomon J. C. Mechanism of inhibition of tumour growth by aspirin and indomethacin. Br J Cancer. 1978 Oct;38(4):503–512. doi: 10.1038/bjc.1978.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mennie A. T., Dalley V. M., Dinneen L. C., Collier H. O. Treatment of radiation-induced gastrointestinal distress with acetylsalicylate. Lancet. 1975 Nov 15;2(7942):942–943. doi: 10.1016/s0140-6736(75)90358-x. [DOI] [PubMed] [Google Scholar]
  16. Northover B. J. Effect of anti-inflammatory drugs on the binding of calcium to cellular membranes in various human and guinea-pig tissues. Br J Pharmacol. 1973 Jul;48(3):496–504. doi: 10.1111/j.1476-5381.1973.tb08356.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. O'Connor A. D., Clifford P., Smith D. J., Edwards W., Hollis B. A., Dalley V. M. Synchronous VBM and radiotherapy in the treatment of squamous cell carcinoma of the head and neck. Clin Otolaryngol Allied Sci. 1977 Nov;2(4):347–357. doi: 10.1111/j.1365-2273.1977.tb01378.x. [DOI] [PubMed] [Google Scholar]
  18. Plescia O. J., Smith A. H., Grinwich K. Subversion of immune system by tumor cells and role of prostaglandins. Proc Natl Acad Sci U S A. 1975 May;72(5):1848–1851. doi: 10.1073/pnas.72.5.1848. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Powles T. J., Alexander P., Millar J. L. Enhancement of anti-cancer activity of cytotoxic chemotherapy with protection of normal tissues by inhibition of P.G. synthesis. Biochem Pharmacol. 1978 May 1;27(9):1389–1392. doi: 10.1016/0006-2952(78)90127-2. [DOI] [PubMed] [Google Scholar]
  20. Powles T. J., Millar J. L. Non-steroidal anti-inflammatory drugs and cytotoxics. Cancer Treat Rev. 1979 Jun;6 (Suppl):63–67. doi: 10.1016/s0305-7372(79)80014-6. [DOI] [PubMed] [Google Scholar]
  21. Robert A. Cytoprotection by prostaglandins. Gastroenterology. 1979 Oct;77(4 Pt 1):761–767. [PubMed] [Google Scholar]
  22. Schiffman F. J., Uehara Y., Fisher J. M., Rabinovitz M. Potentiation of chlorambucil activity by phenylbutazone. Cancer Lett. 1978 Apr;4(4):211–216. doi: 10.1016/s0304-3835(78)94567-6. [DOI] [PubMed] [Google Scholar]
  23. Tanner N. S., Stamford I. F., Bennett A. Plasma prostaglandins in mucositis due to radiotherapy and chemotherapy for head and neck cancer. Br J Cancer. 1981 Jun;43(6):767–771. doi: 10.1038/bjc.1981.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Tutton P. J., Barkla D. H. Influence of prostaglandin analogues on epithelial cell proliferation and xenograft growth. Br J Cancer. 1980 Jan;41(1):47–51. doi: 10.1038/bjc.1980.6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Unger W. G., Stamford I. F., Bennett A. Extraction of prostaglandins from human blood. Nature. 1971 Oct 1;233(5318):336–337. doi: 10.1038/233336b0. [DOI] [PubMed] [Google Scholar]

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