Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1982 May;45(5):670–678. doi: 10.1038/bjc.1982.107

Burkitt-type lymphoma in France among non-Hodgkin malignant lymphomas in Caucasian children.

T Philip, G M Lenoir, P A Bryon, R Gerard-Marchant, G Souillet, N Philippe, F Freycon, M Brunat-Mentigny
PMCID: PMC2011007  PMID: 7082553

Abstract

In a retrospective analysis of 87 cases of Caucasian childhood non-Hodgkin malignant lymphoma (NHML) from Lyon, France, all the case were diffuse lymphomas, but 47 were diagnosed as monomorphic small non-cleaved NHML, pathologically indistinguishable from Burkitt's lymphoma (BL). BL could then be the most frequent childhood lymphoma in France. This homogeneous series allows better definition of the characteristics of BL within NHML. Age distribution is similar to that of endemic BL, with a sex ratio of 3.7/1. Abdominal masses are initially present in 68% of the cases, whereas jaw is involved in only 4%. The disease is characterized by its overwhelming evolution in the absence of therapy. However, complete remission (CR) is usually obtained after the first chemtherapy regimen. Most relapses occur at 3-8 months. Death could be related to cerebrospinal fluid (CSF) involvement, local recurrence or secondary marrow involvement. Ninety per cent of the patients alive with no evidence of disease (NED) 8 months after CR can be considered as definitely cured. Our study on Caucasian children with NHML indicates that, from histological and clinical criteria, nearly half the cases are very similar to African BL. Even though EBV rarely associated with our cases, BL could be a worldwide lymphoma.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ablashi D. V., De-Thé G. B., Easton J. M., Liabeuf A., Levine P. H., Armstrong G. R. Antibodies to Epstein-Barr virus (EBV) antigens in sera of American Burkitt lymphoma patients. Biomedicine. 1974 Jul;21(7):288–293. [PubMed] [Google Scholar]
  2. Appelbaum F. R., Herzig G. P., Ziegler J. L., Graw R. G., Levine A. S., Deisseroth A. B. Successful engraftment of cryopreserved autologous bone marrow in patients with malignant lymphoma. Blood. 1978 Jul;52(1):85–95. [PubMed] [Google Scholar]
  3. Arseneau J. C., Canellos G. P., Banks P. M., Berard C. W., Gralnick H. R., DeVita V. T., Jr American Burkitt's lymphoma: a clinicopathologic study of 30 cases. I. Clinical factors relating to prolonged survival. Am J Med. 1975 Mar;58(3):314–321. doi: 10.1016/0002-9343(75)90597-5. [DOI] [PubMed] [Google Scholar]
  4. BURKITT D. A children's cancer dependent on climatic factors. Nature. 1962 Apr 21;194:232–234. doi: 10.1038/194232a0. [DOI] [PubMed] [Google Scholar]
  5. BURKITT D. A sarcoma involving the jaws in African children. Br J Surg. 1958 Nov;46(197):218–223. doi: 10.1002/bjs.18004619704. [DOI] [PubMed] [Google Scholar]
  6. Banks P. M., Arseneau J. C., Gralnick H. R., Canellos G. P., DeVita V. T., Jr, Berard C. W. American Burkitt's lymphoma: a clinicopathologic study of 30 cases. II. Pathologic correlations. Am J Med. 1975 Mar;58(3):322–329. doi: 10.1016/0002-9343(75)90598-7. [DOI] [PubMed] [Google Scholar]
  7. Bernheim A., Berger R., Lenoir G. Cytogenetic studies on African Burkitt's lymphoma cell lines: t(8;14), t(2;8) and t(8;22) translocations. Cancer Genet Cytogenet. 1981 Jun;3(4):307–315. doi: 10.1016/0165-4608(81)90039-x. [DOI] [PubMed] [Google Scholar]
  8. Bertrand S., Berger R., Philip T., Bernheim A., Bryon P. A., Bertoglio J., Doré J. F., Brunat-Mentigny M., Lenoir G. M. Variant translocation in a non endemic case of Burkitt's lymphoma: t (8;22) in an Epstein--Barr virus negative tumour and in a derived cell line. Eur J Cancer. 1981 May;17(5):577–584. doi: 10.1016/0014-2964(81)90060-8. [DOI] [PubMed] [Google Scholar]
  9. Cohen M. H., Bennett J. M., Berard C. W., Ziegler J. L., Vogel C. L., Sheagren J. N., Carbone P. P. Burkitt's tumor in the United States. Cancer. 1969 Jun;23(6):1259–1272. doi: 10.1002/1097-0142(196906)23:6<1259::aid-cncr2820230604>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  10. DORFMAN R. F. CHILDHOOD LYMPHOSARCOMA IN ST. LOUIS, MISSOURI, CLINICALLY AND HISTOLOGICALLY RESEMBLING BURKITT'S TUMOR. Cancer. 1965 Apr;18:418–430. doi: 10.1002/1097-0142(196504)18:4<418::aid-cncr2820180404>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  11. EPSTEIN M. A., ACHONG B. G., BARR Y. M. VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. Lancet. 1964 Mar 28;1(7335):702–703. doi: 10.1016/s0140-6736(64)91524-7. [DOI] [PubMed] [Google Scholar]
  12. Garwicz S., Landberg T., Akerman M. Malignant lymphomas in children. A clinico-pathologic retrospective study. II. Non-Hodgkin's lymphomas. Acta Paediatr Scand. 1974 Sep;63(5):679–686. doi: 10.1111/j.1651-2227.1974.tb16990.x. [DOI] [PubMed] [Google Scholar]
  13. Gout-Lemerle M., Rodary C., Sarrazin D. Le traitement des lymphomes malins non hodgkiniens de l'enfant. Arch Fr Pediatr. 1976 Jun-Jul;33(6):537–553. [PubMed] [Google Scholar]
  14. Hirshaut Y., Cohen M. H., Stevens D. A. Epstein-Barr-virus antibodies in American and African Burkitt's lymphoma. Lancet. 1973 Jul 21;2(7821):114–116. doi: 10.1016/s0140-6736(73)93061-4. [DOI] [PubMed] [Google Scholar]
  15. Histopathological definition of Burkitt's tumour. Bull World Health Organ. 1969 Apr;40(4):601–607. [PMC free article] [PubMed] [Google Scholar]
  16. Hoogstraten J. Observations on Burkitt's tumour in central and northern Canada. Int J Cancer. 1967 Nov 15;2(6):566–575. doi: 10.1002/ijc.2910020604. [DOI] [PubMed] [Google Scholar]
  17. Joncas J. H., Rioux E. Burkitt's lymphoma of the jaw in a Canadian child. Can Med Assoc J. 1977 Aug 20;117(4):367–368. [PMC free article] [PubMed] [Google Scholar]
  18. Klein G. Studies on the Epstein-Barr Virus genome and the EBV-determined nuclear antigen in human malignant disease. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):783–790. doi: 10.1101/sqb.1974.039.01.090. [DOI] [PubMed] [Google Scholar]
  19. Levine P. H., Cho B. R. Burkitt's lymphoma: clinical features of North American cases. Cancer Res. 1974 May;34(5):1219–1221. [PubMed] [Google Scholar]
  20. Levine P. H., Kamaraju L. S., Connelly R. R., Berard C. W., Dorfman R. F., Magrath I., Easton J. M. The American Burkitt's Lymphoma Registry: eight years' experience. Cancer. 1982 Mar 1;49(5):1016–1022. doi: 10.1002/1097-0142(19820301)49:5<1016::aid-cncr2820490527>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  21. Mann R. B., Jaffe E. S., Braylan R. C., Nanba K., Frank M. M., Ziegler J. L., Berard C. W. Non-endemic Burkitts's lymphoma. A B-cell tumor related to germinal centers. N Engl J Med. 1976 Sep 23;295(13):685–691. doi: 10.1056/NEJM197609232951301. [DOI] [PubMed] [Google Scholar]
  22. Murphy S. B. Prognostic features and obstacles to cure of childhood non-Hodgkin's lymphoma. Semin Oncol. 1977 Sep;4(3):265–271. [PubMed] [Google Scholar]
  23. Olweny C. L., Katongole-Mbidde E., Otim D., Lwanga S. K., Magrath I. T., Ziegler J. L. Long-term experience with Burkitt's lymphoma in Uganda. Int J Cancer. 1980 Sep 15;26(3):261–266. doi: 10.1002/ijc.2910260302. [DOI] [PubMed] [Google Scholar]
  24. Philip T., Bryon P. A., Philippe N., Souillet G., Freycon F., Gérard-Marchant R., Brunat-Mentigny M. Individualisation anatomo-clinique du lymphome de Burkitt en France. A propos de 51 cas personnels. Pediatrie. 1980;35(8):677–691. [PubMed] [Google Scholar]
  25. Pineda Cuevas G., Alvarez Silván A., García Cantón J., Fernández Delgado J., López Guerrero D. Linfoma de Burkitt. Aportación de un caso. An Esp Pediatr. 1976 Jun;9(4 Suppl):104–109. [PubMed] [Google Scholar]
  26. Wollner N., Wachtel A. E., Exelby P. R., Centore D. Improved prognosis in children with intra-abdominal non-Hodgkin's lymphoma following LSA2L2 protocol chemotherapy. Cancer. 1980 Jun 15;45(12):3034–3039. doi: 10.1002/1097-0142(19800615)45:12<3034::aid-cncr2820451226>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  27. Wright D. H. Burkitt's tumour in England. A comparison with childhood lymphosarcoma. Int J Cancer. 1966 Sep 15;1(5):503–514. doi: 10.1002/ijc.2910010510. [DOI] [PubMed] [Google Scholar]
  28. Ziegler J. L. Treatment results of 54 American patients with Burkitt's lymphoma are similar to the African experience. N Engl J Med. 1977 Jul 14;297(2):75–80. doi: 10.1056/NEJM197707142970202. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES