Abstract
Serum sialyl transferase (SST) was measured in 49 female patients with advanced breast cancer and 60 female controls. The mean SST level was significantly raised in patients with advanced breast cancer. There was no correlation between specific sites, or numbers of sites of metastatic disease and SST levels. The patients with advanced breast cancer were all treated with chemotherapy; in 13/21 responders there was a significant fall in SST and in 2 responders a significant rise in SST. The 6 patients who died after one course of chemotherapy had a significantly higher mean SST than those surviving longer. SST appears to lack sufficient specificity to be of practical value as a marker of response in patients with breast cancer treated by chemotherapy, though constant measurement of changes in SST may be of use in monitoring drug response. Raised SST at the commencement of chemotherapy may signify poor prognosis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dao T. L., Ip C., Patel J. Serum sialyltransferase and 5'-nucleotidase as reliable biomarkers in women with breast cancer. J Natl Cancer Inst. 1980 Sep;65(3):529–534. [PubMed] [Google Scholar]
- Evans I. M., Hilf R., Murphy M., Bosmann H. B. Correlation of serum, tumor, and liver serum glycoprotein: N-acetylneuraminic acid transferase activity with growth of the R3230AC mammary tumor in rats and relationship of the serum activity to tumor burden. Cancer Res. 1980 Sep;40(9):3103–3111. [PubMed] [Google Scholar]
- Ganzinger U., Deutsch E. Serum sialyltransferase levels as a parameter in the diagnosis and follow-up of gastrointestinal tumors. Cancer Res. 1980 Apr;40(4):1300–1304. [PubMed] [Google Scholar]
- Ganzinger U., Moser K. Sialyl transferase activity: a serum enzyme marker in the follow-up of cancer patients. Recent Results Cancer Res. 1979;67:50–55. doi: 10.1007/978-3-642-81320-7_8. [DOI] [PubMed] [Google Scholar]
- Hayward J. L., Carbone P. P., Heusen J. C., Kumaoka S., Segaloff A., Rubens R. D. Assessment of response to therapy in advanced breast cancer. Br J Cancer. 1977 Mar;35(3):292–298. doi: 10.1038/bjc.1977.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henderson M., Kessel D. Alterations in plasma sialyltransferase levels in patients with neoplastic disease. Cancer. 1977 Mar;39(3):1129–1134. doi: 10.1002/1097-0142(197703)39:3<1129::aid-cncr2820390318>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
- Kessel D. H., Chou T. H., Coombes R. C. Studies on sialyltransferase isoenzymes in plasma of patients with breast cancer. Eur J Cancer Clin Oncol. 1981 Sep;17(9):1035–1040. doi: 10.1016/s0277-5379(81)80010-7. [DOI] [PubMed] [Google Scholar]
- Kessel D., Allen J. Elevated plasma sialyltransferase in the cancer patient. Cancer Res. 1975 Mar;35(3):670–672. [PubMed] [Google Scholar]
- Khilanani P., Chou T. H., Ratanatharathorn V., Kessel D. Evaluation of two plasma fucosyltransferases as marker enzymes in non-Hodgkin's lymphoma. Cancer. 1978 Feb;41(2):701–705. doi: 10.1002/1097-0142(197802)41:2<701::aid-cncr2820410241>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
- van Beek W. P., Smets L. A., Emmelot P. Increased sialic acid density in surface glycoprotein of transformed and malignant cells--a general phenomenon? Cancer Res. 1973 Nov;33(11):2913–2922. [PubMed] [Google Scholar]