Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1982 Aug;46(2):213–219. doi: 10.1038/bjc.1982.186

Tumour lysis as a factor affecting blood levels of CEA.

J B Quayle
PMCID: PMC2011095  PMID: 6817775

Abstract

A hypothesis is proposed that tumour lysis may be an important factor affecting blood levels of CEA. This has been explored in an experimental study with a model tumour system, consisting of immune-deprived mice bearing human CEA-producing tumours. Using agents such as irradiation, chemotherapeutic drugs, diphtheria toxin and techniques such as cryosurgery, it has been shown that tumour lysis is important when it is both rapid and extensive. The extent to which this may occur in patients remains uncertain, except in rare instances of dramatic response of malignant disease to treatment.

Full text

PDF
213

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borthwick N. M., Wilson D. W., Bell P. A. Carcinoembryonic antigen (CEA) in patients with breast cancer. Eur J Cancer. 1977 Feb;13(2):171–176. doi: 10.1016/0014-2964(77)90196-7. [DOI] [PubMed] [Google Scholar]
  2. Carter S. K. Integration of chemotherapy into combined modality treatment of solid tumors VII. Adenocarcinoma of the breast. Cancer Treat Rev. 1976 Sep;3(3):141–174. doi: 10.1016/s0305-7372(76)80020-5. [DOI] [PubMed] [Google Scholar]
  3. Donaldson E., Van Nagell J. R., Jr, Wood E. G., Pletsch Q., Goldenberg D. M. Carcinoembryonic antigen in patients treated with radiation therapy for invasive squamous cell carcinoma of the uterine cervix. AJR Am J Roentgenol. 1976 Nov;127(5):829–831. doi: 10.2214/ajr.127.5.829. [DOI] [PubMed] [Google Scholar]
  4. Drewinko B., Yand L. Y. Restriction of CEA synthesis to the stationary phase of growth of cultured human colon carcinoma cells. Exp Cell Res. 1976 Sep;101(2):414–416. doi: 10.1016/0014-4827(76)90393-1. [DOI] [PubMed] [Google Scholar]
  5. Drewinko B., Yang L. Y. Observations on the synthesis of carcinoembryonic antigen by an established human colonic carcinoma cell line. Oncology. 1980;37(5):336–342. doi: 10.1159/000225466. [DOI] [PubMed] [Google Scholar]
  6. Khoo S. K., MacKay E. V. Carcinoembryonic antigen (CEA) in ovarian cancer: factors influencing its incidence and changes which occur in response to cytotoxic drugs. Br J Obstet Gynaecol. 1976 Oct;83(10):753–759. doi: 10.1111/j.1471-0528.1976.tb00739.x. [DOI] [PubMed] [Google Scholar]
  7. Mayer R. J., Garnick M. B., Steele G. D., Jr, Zamcheck N. Carcinoembryonic antigen (CEA) as a monitor of chemotherapy in disseminated colorectal cancer. Cancer. 1978 Sep;42(3 Suppl):1428–1433. doi: 10.1002/1097-0142(197809)42:3+<1428::aid-cncr2820420808>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  8. Mitchley B. C., Clarke S. A., Connors T. A., Carter S. M., Neville A. M. Chemotherapy of human tumors in T-lymphocyte-deficient mice. Cancer Treat Rep. 1977 May-Jun;61(3):451–462. [PubMed] [Google Scholar]
  9. Nowak K., Peckham M. J., Steel G. G. Variation in response of xenografts of colo-rectal carcinoma to chemotherapy. Br J Cancer. 1978 Apr;37(4):576–584. doi: 10.1038/bjc.1978.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Quayle J. B. Ability of CEA blood levels to reflect tumour burden: a study in a human xenograft model. Br J Cancer. 1982 Aug;46(2):220–227. doi: 10.1038/bjc.1982.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ravry M., Moertel C. G., Schutt A. J., Go V. L. Usefulness of serial serum carcinoembryonic antigen (CEA) determinations during anticancer therapy or long-term follow-up of gastrointestinal carcinoma. Cancer. 1974 Oct;34(4):1230–1234. doi: 10.1002/1097-0142(197410)34:4<1230::aid-cncr2820340432>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  12. Shani A., O'Connell M. J., Moertel C. G., Schutt A. J., Silvers A., Go V. L. Serial plasma carcinoembryonic antigen measurements in the management of metastatic colorectal carcinoma. Ann Intern Med. 1978 May;88(5):627–630. doi: 10.7326/0003-4819-88-5-627. [DOI] [PubMed] [Google Scholar]
  13. Skarin A. T., Delwiche R., Zamcheck N., Lokich J. J., Frei E., 3rd Carcinoembryonic antigen: clinical correlation with chemotherapy for metastatic gastrointestinal cancer. Cancer. 1974 May;33(5):1239–1245. doi: 10.1002/1097-0142(197405)33:5<1239::aid-cncr2820330508>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  14. Steward A. M., Nixon D., Zamcheck N., Aisenberg A. Carcinoembryonic antigen in breast cancer patients: serum levels and disease progress. Cancer. 1974 May;33(5):1246–1252. doi: 10.1002/1097-0142(197405)33:5<1246::aid-cncr2820330509>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  15. Sugarbaker P. H., Bloomer W. D., Corbett E. D., Chaffey J. T. Carcinoembryonic antigen (CEA): its role as a monitor of radiation therapy for colorectal cancer. Cancer. 1978 Sep;42(3 Suppl):1434–1436. doi: 10.1002/1097-0142(197809)42:3+<1434::aid-cncr2820420809>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  16. Waalkes T. P., Abeloff M. D., Woo K. B., Ettinger D. S., Ruddon R. W., Aldenderfer P. Carcinoembryonic antigen for monitoring patients with small cell carcinoma of the lung during treatment. Cancer Res. 1980 Dec;40(12):4420–4427. [PubMed] [Google Scholar]
  17. Young V. L., Kashmiri R., Hazen Z. R., Meeker W. R., Jr Usefulness of serial carcinoembryonic antigen (CEA) determinations in monitoring chemotherapy. South Med J. 1976 Oct;69(10):1274–1276. doi: 10.1097/00007611-197610000-00008. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES