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. 1982 Nov;46(5):721–728. doi: 10.1038/bjc.1982.264

Epstein-Barr virus in nasopharyngeal and salivary gland carcinomas of Greenland Eskimoes.

A K Saemundsen, H Albeck, J P Hansen, N H Nielsen, M Anvret, W Henle, G Henle, K A Thomsen, H K Kristensen, G Klein
PMCID: PMC2011144  PMID: 6293523

Abstract

Biopsy specimens from nasopharyngeal carcinomas (NPC) or salivary-gland carcinomas (SGC) in Greenland Eskimoes were examined for the presence of Epstein-Barr virus (EBV) DNA and sera from the patients were tested for EBV-specific antibody titres. Six out of 7 NPCs and one from an undifferentiated SGG were positive for EBV DNA. The EBV-specific antibody spectra and titres of the patients with NPC or undifferentiated SGG conformed to the results of earlier studies in other high-incidence areas.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson-Anvret M., Forsby N., Klein G., Henle W., Biörklund A. Relationship between the Epstein-Barr virus genome and nasopharyngeal carcinoma in Caucasian patients. Int J Cancer. 1979 Jun 15;23(6):762–767. doi: 10.1002/ijc.2910230605. [DOI] [PubMed] [Google Scholar]
  2. Andersson-Anvret M., Forsby N., Klein G., Henle W. Relationship between the Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma: correlated nucleic acid hybridization and histopathological examination. Int J Cancer. 1977 Oct 15;20(4):486–494. doi: 10.1002/ijc.2910200403. [DOI] [PubMed] [Google Scholar]
  3. Andersson-Anvret M., Forsby N., Klein G. Nasopharyngeal carcinoma. Prog Exp Tumor Res. 1978;21:100–116. doi: 10.1159/000400860. [DOI] [PubMed] [Google Scholar]
  4. CLIFFORD P., BEECHER J. L. NASOPHARYNGEAL CANCER IN KENYA: CLINICAL AND ENVIRONMENTAL ASPECTS. Br J Cancer. 1964 Mar;18:25–43. doi: 10.1038/bjc.1964.3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. EPSTEIN M. A., ACHONG B. G., BARR Y. M. VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. Lancet. 1964 Mar 28;1(7335):702–703. doi: 10.1016/s0140-6736(64)91524-7. [DOI] [PubMed] [Google Scholar]
  6. EPSTEIN M. A., HENLE G., ACHONG B. G., BARR Y. M. MORPHOLOGICAL AND BIOLOGICAL STUDIES ON A VIRUS IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. J Exp Med. 1965 May 1;121:761–770. doi: 10.1084/jem.121.5.761. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Henle G., Henle W., Klein G. Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus-infected cells. Int J Cancer. 1971 Sep 15;8(2):272–282. doi: 10.1002/ijc.2910080212. [DOI] [PubMed] [Google Scholar]
  8. Henle W., Henle G. E., Horwitz C. A. Epstein-Barr virus specific diagnostic tests in infectious mononucleosis. Hum Pathol. 1974 Sep;5(5):551–565. doi: 10.1016/s0046-8177(74)80006-7. [DOI] [PubMed] [Google Scholar]
  9. Henle W., Henle G., Ho H. C., Burtin P., Cachin Y., Clifford P., de Schryver A., de-Thé G., Diehl V., Klein G. Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups. J Natl Cancer Inst. 1970 Jan;44(1):225–231. [PubMed] [Google Scholar]
  10. Henle W., Ho J. H., Henle G., Chau J. C., Kwan H. C. Nasopharyngeal carcinoma: significance of changes in Epstein-Barr virus-related antibody patterns following therapy. Int J Cancer. 1977 Nov 15;20(5):663–672. doi: 10.1002/ijc.2910200504. [DOI] [PubMed] [Google Scholar]
  11. Huang D. P., Ho J. H., Henle W., Henle G. Demonstration of Epstein-Barr virus-associated nuclear antigen in nasopharyngeal carcinoma cells from fresh biopsies. Int J Cancer. 1974 Nov 15;14(5):580–588. doi: 10.1002/ijc.2910140504. [DOI] [PubMed] [Google Scholar]
  12. Lanier A. P., Bender T. R., Blot W. J., Fraumeni J. F., Jr, Hurlburt W. B. Cancer incidence in Alaska natives. Int J Cancer. 1976 Oct 15;18(4):409–412. doi: 10.1002/ijc.2910180403. [DOI] [PubMed] [Google Scholar]
  13. Lanier A. P., Bornkamm G. W., Henle W., Henle G., Bender T. R., Talbot M. L., Dohan P. H. Association of Epstein-Barr virus with nasopharyngeal carcinoma in Alaskan native patients: serum antibodies and tissue EBNA and DNA. Int J Cancer. 1981 Sep 15;28(3):301–305. doi: 10.1002/ijc.2910280308. [DOI] [PubMed] [Google Scholar]
  14. Lanier A., Bender T., Talbot M., Wilmeth S., Tschopp C., Henle W., Henle G., Ritter D., Terasaki P. Nasopharyngeal carcinoma in Alaskan Eskimos Indians, and Aleuts: a review of cases and study of Epstein-Barr virus, HLA, and environmental risk factors. Cancer. 1980 Nov 1;46(9):2100–2106. doi: 10.1002/1097-0142(19801101)46:9<2100::aid-cncr2820460932>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  15. Lindahl T., Adams A., Bjursell G., Bornkamm G. W., Kaschka-Dierich C., Jehn U. Covalently closed circular duplex DNA of Epstein-Barr virus in a human lymphoid cell line. J Mol Biol. 1976 Apr 15;102(3):511–530. doi: 10.1016/0022-2836(76)90331-4. [DOI] [PubMed] [Google Scholar]
  16. Morgan D. G., Niederman J. C., Miller G., Smith H. W., Dowaliby J. M. Site of Epstein-Barr virus replication in the oropharynx. Lancet. 1979 Dec 1;2(8153):1154–1157. doi: 10.1016/s0140-6736(79)92384-5. [DOI] [PubMed] [Google Scholar]
  17. Niederman J. C., Miller G., Pearson H. A., Pagano J. S., Dowaliby J. M. Infectious mononucleosis. Epstein-Barr-virus shedding in saliva and the oropharynx. N Engl J Med. 1976 Jun 17;294(25):1355–1359. doi: 10.1056/NEJM197606172942501. [DOI] [PubMed] [Google Scholar]
  18. Nielsen N. H., Mikkelsen F., Hansen J. P. Incidence of salivary gland neoplasms in Greenland with special reference to an anaplastic carcinoma. Acta Pathol Microbiol Scand A. 1978 Mar;86(2):185–193. doi: 10.1111/j.1699-0463.1978.tb02030.x. [DOI] [PubMed] [Google Scholar]
  19. Nielsen N. H., Mikkelsen F., Hansen J. P. Nasopharyngeal cancer in Greenland. The incidence in an Arctic Eskimo population. Acta Pathol Microbiol Scand A. 1977 Nov;85(6):850–858. [PubMed] [Google Scholar]
  20. Nonoyama M., Huang C. H., Pagano J. S., Klein G., Singh S. DNA of Epstein-Barr virus detected in tissue of Burkitt's lymphoma and nasopharyngeal carcinoma. Proc Natl Acad Sci U S A. 1973 Nov;70(11):3265–3268. doi: 10.1073/pnas.70.11.3265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Old L. J., Boyse E. A., Oettgen H. F., Harven E. D., Geering G., Williamson B., Clifford P. Precipitating antibody in human serum to an antigen present in cultured burkitt's lymphoma cells. Proc Natl Acad Sci U S A. 1966 Dec;56(6):1699–1704. doi: 10.1073/pnas.56.6.1699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Pettersson U., Sambrook J. Amount of viral DNA in the genome of cells transformed by adenovirus type 2. J Mol Biol. 1973 Jan;73(1):125–130. doi: 10.1016/0022-2836(73)90164-2. [DOI] [PubMed] [Google Scholar]
  23. Reedman B. M., Klein G. Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines. Int J Cancer. 1973 May;11(3):499–520. doi: 10.1002/ijc.2910110302. [DOI] [PubMed] [Google Scholar]
  24. Rymo L. Identification of transcribed regions of Epstein-Barr virus DNA in Burkitt lymphoma-derived cells. J Virol. 1979 Oct;32(1):8–18. doi: 10.1128/jvi.32.1.8-18.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Saemundsen A. K., Purtilo D. T., Sakamoto K., Sullivan J. L., Synnerholm A. C., Hanto D., Simmons R., Anvret M., Collins R., Klein G. Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by Epstein-Barr virus complementary RNA/DNA and viral DNA/DNA hybridization. Cancer Res. 1981 Nov;41(11 Pt 1):4237–4242. [PubMed] [Google Scholar]
  26. Schaefer O., Hildes J. A., Medd L. M., Cameron D. G. The changing pattern of neoplastic disease in Canadian Eskimos. Can Med Assoc J. 1975 Jun 21;112(12):1399–1404. [PMC free article] [PubMed] [Google Scholar]
  27. Schmauz R., Templeton A. C. Nasopharyngeal carcinoma in Uganda. Cancer. 1972 Mar;29(3):610–621. doi: 10.1002/1097-0142(197203)29:3<610::aid-cncr2820290313>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  28. Wolf H., Zur Hausen H., Klein G., Becker V., Henle G., Henle W. Attempts to detect virus-specific DNA sequences in human tumors. III. Epstein-Barr viral DNA in non-lymphoid nasopharyngeal carcinoma cells. Med Microbiol Immunol. 1975;161(1):15–21. doi: 10.1007/BF02120766. [DOI] [PubMed] [Google Scholar]
  29. Wolf H., zur Hausen H., Becker V. EB viral genomes in epithelial nasopharyngeal carcinoma cells. Nat New Biol. 1973 Aug 22;244(138):245–247. doi: 10.1038/newbio244245a0. [DOI] [PubMed] [Google Scholar]
  30. de-The G., Lavoue M. F., Muenz L. Differences in EBV antibody titres of patients with nasopharyngeal carcinoma originating from high, intermediate and low incidence areas. IARC Sci Publ. 1978;(20):471–481. [PubMed] [Google Scholar]
  31. zur Hausen H., Schulte-Holthausen H., Wolf H., Dörries K., Egger H. Attempts to detect virus-specific DNA in human tumors. II. Nucleic acid hybridizations with complementary RNA of human herpes group viruses. Int J Cancer. 1974 May 15;13(5):657–664. doi: 10.1002/ijc.2910130510. [DOI] [PubMed] [Google Scholar]

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