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British Journal of Cancer logoLink to British Journal of Cancer
. 1982 Oct;46(4):662–667. doi: 10.1038/bjc.1982.251

Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig.

W E Perkins, R L Schroeder, R A Carrano, A R Imondi
PMCID: PMC2011185  PMID: 6814473

Abstract

ICRF-187 was tested for cardioprotective activity in doxorubicin-treated mice and guinea pigs. Pretreatment with i.p. ICRF-187 caused a significant decrease in the indicence of i.v. doxorubicin-induced myocardial histological damage in the mouse. I.p. ICRF-187 did not, however, reduce the effect of i.p. doxorubicin on a functional myocardial effect of this antitumour drug, a reduced histamine responsiveness of right atria in vitro. These data suggest that ICRF-187 may not be specific for all the cardiac effects of doxorubicin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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