Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1982 Oct;46(4):551–556. doi: 10.1038/bjc.1982.239

Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C

Interim report from a randomized multicentre study

I Balslev, M Pedersen, P S Teglbjaerg, F Hanberg-Sørensen, J Bone, N O Jacobsen, J Overgaard, A Sell, K Bertelsen, E Hage, L Hansen, O Kronborg, H Høstrup, B Nørgaard-Pedersen
PMCID: PMC2011200  PMID: 6753912

Abstract

The design, and complications seen during the first 2 years, of a randomized trial of postoperative radiotherapy for rectosigmoid cancer Dukes' B and C are presented and discussed. It is concluded that the present complication rate—below 10% in 221 patients—permits continuation of the intake, which is planned to include 550 patients, to demonstrate a possible increase in crude 5-year survival by 15% (60-75% in Dukes' B and 25-40% in Dukes' C), on the basis of a 0·01 significance level and a probability that the experiment will be successful of 0·90.

Full text

PDF
551

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cram A. E., Pearlman N. W., Jochimsen P. R. Surgical management of complications of radiation-injured gut. Am J Surg. 1977 May;133(5):551–553. doi: 10.1016/0002-9610(77)90004-6. [DOI] [PubMed] [Google Scholar]
  2. Deitel M., Vasic V. Major intestinal complications of radiotherapy. Am J Gastroenterol. 1979 Jul;72(1):65–70. [PubMed] [Google Scholar]
  3. Green J. P. Rectal cancer: adjuvant radiation therapy. Front Radiat Ther Oncol. 1980;15:102–108. doi: 10.1159/000394376. [DOI] [PubMed] [Google Scholar]
  4. Gunderson L. L. Radiation therapy: results and future possibilities. Clin Gastroenterol. 1976 Sep;5(3):743–776. [PubMed] [Google Scholar]
  5. LoIudice T., Baxter D., Balint J. Effects of abdominal surgery on the development of radiation enteropathy. Gastroenterology. 1977 Nov;73(5):1093–1097. [PubMed] [Google Scholar]
  6. Mendiondo O. A., Wang C. C., Welch J. P., Donaldson G. A. Postoperative radiotherapy in carcinomas of the rectum and distal sigmoid colon. Radiology. 1976 Jun;119(3):673–676. doi: 10.1148/119.3.673. [DOI] [PubMed] [Google Scholar]
  7. Roswit B., Higgins G. A., Humphrey E. W., Robinette C. D. Preoperative irradiation of operable adenocarcinoma of the rectum and rectosigmoid colon. Radiology. 1973 Aug;108(2):389–395. doi: 10.1148/108.2.389. [DOI] [PubMed] [Google Scholar]
  8. Russell J. C., Welch J. P. Operative management of radiation injuries of the intestinal tract. Am J Surg. 1979 Apr;137(4):433–442. doi: 10.1016/0002-9610(79)90111-9. [DOI] [PubMed] [Google Scholar]
  9. Stevens K. R., Jr, Allen C. V., Fletcher W. S. Preoperative radiotherapy for adenocarcinoma of the rectosigmoid. Cancer. 1976 Jun;37(6):2866–2874. doi: 10.1002/1097-0142(197606)37:6<2866::aid-cncr2820370644>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  10. Swan R. W., Fowler W. C., Jr, Boronow R. C. Surgical management of radiation injury to the small intestine. Surg Gynecol Obstet. 1976 Mar;142(3):325–327. [PubMed] [Google Scholar]
  11. Turner S. S., Vieira E. F., Ager P. J., Alpert S., Efron G., Ragins H., Weil P., Ghossein N. A. Elective postoperative radiotherapy for locally advanced colorectal cancer. A preliminary report. Cancer. 1977 Jul;40(1):105–108. doi: 10.1002/1097-0142(197707)40:1<105::aid-cncr2820400119>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  12. Withers H. R., Romsdahl M. M. Post-operative radiotherapy for adenocarcinoma of the rectum and rectosigmoid. Int J Radiat Oncol Biol Phys. 1977 Nov-Dec;2(11-12):1069–1074. doi: 10.1016/0360-3016(77)90111-0. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES