Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1983 Feb;47(2):303–305. doi: 10.1038/bjc.1983.40

Is folate absorption impaired by high dose methotrexate?

C R Pinkerton
PMCID: PMC2011277  PMID: 6824572

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Capel I. D., Pinnock M. H., Williams D. C. An in vitro assessment of the effect of cytotoxic drugs upon the intestinal absorption of nutrients in rats. Eur J Cancer. 1979 Jan;15(1):127–131. doi: 10.1016/0014-2964(79)90214-7. [DOI] [PubMed] [Google Scholar]
  2. DELMONTE L., JUKES T. H. Folic acid antagonists in cancer chemotherapy. Pharmacol Rev. 1962 Mar;14:91–135. [PubMed] [Google Scholar]
  3. Gwavava N. J., Pinkerton C. R., Glasgow J. F., Sloan J. M., Bridges J. M. Small bowel enterocyte abnormalities caused by methotrexate treatment in acute lymphoblastic leukaemia of childhood. J Clin Pathol. 1981 Jul;34(7):790–795. doi: 10.1136/jcp.34.7.790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hoffbrand A. V., Fry L. Effect of methotrexate on absorption of folates. Lancet. 1972 Nov 11;2(7785):1025–1025. doi: 10.1016/s0140-6736(72)92434-8. [DOI] [PubMed] [Google Scholar]
  5. Kirwan J. R., Narebor E. M. Absorption of large oral doses of 5-formyltetrahydrofolate in man. Br J Cancer. 1976 Dec;34(6):671–673. doi: 10.1038/bjc.1976.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lei F. H., Lucas M. L., Blair J. A. The influence of pH, low sodium ion concentration and methotrexate on the jejunal-surface pH: a model for folic acid transfer. Biochem Soc Trans. 1977;5(1):149–152. doi: 10.1042/bst0050149. [DOI] [PubMed] [Google Scholar]
  7. Pearson A. D., Eastham E. J., Laker M. F., Craft A. W., Nelson R. Intestinal permeability in children with Crohn's disease and coeliac disease. Br Med J (Clin Res Ed) 1982 Jul 3;285(6334):20–21. doi: 10.1136/bmj.285.6334.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Rosenberg I. H. Absorption and malabsorption of folates. Clin Haematol. 1976 Oct;5(3):589–618. [PubMed] [Google Scholar]
  9. Selhub J., Brin H., Grossowicz N. Uptake and reduction of radioactive folate by everted sacs of rat small intestine. Eur J Biochem. 1973 Mar 15;33(3):433–438. doi: 10.1111/j.1432-1033.1973.tb02700.x. [DOI] [PubMed] [Google Scholar]
  10. Shaw M. T., Spector M. H., Ladman A. J. Effects of cancer, radiotherapy and cytotoxic drugs on intestinal structure and function. Cancer Treat Rev. 1979 Sep;6(3):141–151. doi: 10.1016/s0305-7372(79)80066-3. [DOI] [PubMed] [Google Scholar]
  11. Sladen G. E., Dawson A. M. Interrelationships between the absorptions of glucose, sodium and water by the normal human jejunum. Clin Sci. 1969 Feb;36(1):119–132. [PubMed] [Google Scholar]
  12. Sladen G. E., Harries J. T. Studies on the effects of unconjugated dihydroxy bile salts on rat small intestinal function in vivo. Biochim Biophys Acta. 1972 Nov 2;288(2):443–456. doi: 10.1016/0005-2736(72)90265-9. [DOI] [PubMed] [Google Scholar]
  13. TRIER J. S. Morphologic alterations induced by methotrexate in the mucosa of human proximal intestine. II. Electron microscopic observations. Gastroenterology. 1962 Oct;43:407–424. [PubMed] [Google Scholar]
  14. Taminiau J. A., Gall D. G., Hamilton J. R. Response of the rat small-intestine epithelium to methotrexate. Gut. 1980 Jun;21(6):486–492. doi: 10.1136/gut.21.6.486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. VITALE J. J., ZAMCHECK N., DIGIORGIO J., HEGSTED D. M. Effects of aminopterin administration on the respiration and morphology of the gastrointestinal mucosa of rats. J Lab Clin Med. 1954 Apr;43(4):583–594. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES