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. 1983 Feb;47(2):277–284. doi: 10.1038/bjc.1983.36

Reverse transcriptase activity and particles of retroviral density in cultured canine lymphosarcoma supernatants.

F M Tomley, S J Armstrong, B W Mahy, L N Owen
PMCID: PMC2011285  PMID: 6186265

Abstract

Lymphoid tissue from 43 cases of canine lymphosarcoma and from 40 clinically normal dogs have been examined for markers of retrovirus infection. From 69-76% of culture supernatants from lymphosarcomas were shown to contain particles of retroviral density and to possess poly rC-oligo dG templated polymerase (reverse transcriptase) activity compared with 17-24% of culture supernatants from normal canine lymphoid cells. In 6 culture supernatants from cases of lymphosarcoma, high molecular weight 60-70S RNA was detected and shown to be found in association with this particulate reverse transcriptase activity. No such RNA was detected in 6 culture supernatants from normal canine lymphoid cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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