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. 1983 Feb;47(2):261–267. doi: 10.1038/bjc.1983.34

Intra-tumoural variation of oestrogen receptor status in endometrial cancer.

L Castagnetta, M Lo Casto, T Mercadante, L Polito, S Cowan, R E Leake
PMCID: PMC2011289  PMID: 6824570

Abstract

Soluble and nuclear oestrogen receptor status was determined in both the central and peripheral portions of tumour for 37 cases of adenocarcinoma of the endometrium. Of these, 29 had functional receptor in the peripheral biopsy, but only 19 retained functional receptor in the centre. Six of the 10 patients whose tumours showed this difference came from the group of 12 patients who were immediately post-menopausal (4.50 +/- 1.45 y post-menopausal age). Receptor status was not related to tumour classification into histological grades I and II. However, receptor-negative central biopsies were significantly more likely (P less than 0.05) to be Grade III. Early relapse was also related to a receptor-negative central biopsy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnes D. M., Skinner L. G., Ribeiro G. G. Triple hormone-receptor assay: a more accurate predictive tool for the treatment of advanced breast cancer? Br J Cancer. 1979 Dec;40(6):862–865. doi: 10.1038/bjc.1979.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bayard F., Damilano S., Robel P., Baulieu E. E. Cytoplasmic and nuclear estradiol and progesterone receptors in human endometrium. J Clin Endocrinol Metab. 1978 Apr;46(4):635–648. doi: 10.1210/jcem-46-4-635. [DOI] [PubMed] [Google Scholar]
  3. Benraad T. J., Friberg L. G., Koenders A. J., Kullander S. Do estrogen and progesterone receptors (E2R and PR) in metastasizing endometrial cancers predict the response to gestagen therapy? Acta Obstet Gynecol Scand. 1980;59(2):155–159. doi: 10.3109/00016348009154633. [DOI] [PubMed] [Google Scholar]
  4. Bishop H. M., Blamey R. W., Elston C. W., Haybittle J. L., Nicholson R. I., Griffiths K. Relationship of oestrogen-receptor status to survival in breast cancer. Lancet. 1979 Aug 11;2(8137):283–284. doi: 10.1016/s0140-6736(79)90295-2. [DOI] [PubMed] [Google Scholar]
  5. Edwards D. P., Chamness G. C., McGuire W. L. Estrogen and progesterone receptor proteins in breast cancer. Biochim Biophys Acta. 1979 Dec 19;560(4):457–486. doi: 10.1016/0304-419x(79)90013-1. [DOI] [PubMed] [Google Scholar]
  6. Feil P. D., Mann W. J., Jr, Mortel R., Bardin C. W. Nuclear progestin receptors in normal and malignant human endometrium. J Clin Endocrinol Metab. 1979 Feb;48(2):327–334. doi: 10.1210/jcem-48-2-327. [DOI] [PubMed] [Google Scholar]
  7. Geier A., Beery R., Levran D., Menczer J., Lunenfeld B. Unoccupied nuclear receptors for estrogen in human endometrial tissue. J Clin Endocrinol Metab. 1980 Mar;50(3):541–545. doi: 10.1210/jcem-50-3-541. [DOI] [PubMed] [Google Scholar]
  8. Gurpide E., Gusberg S. B., Tseng L. Estradiol binding and metabolism in human endometrial hyperplasia and adenocarcinoma. J Steroid Biochem. 1976 Nov-Dec;7(11-12):891–896. doi: 10.1016/0022-4731(76)90007-8. [DOI] [PubMed] [Google Scholar]
  9. Hawkins R. A., Roberts M. M., Forrest A. P. Oestrogen receptors and breast cancer: current status. Br J Surg. 1980 Mar;67(3):153–169. doi: 10.1002/bjs.1800670302. [DOI] [PubMed] [Google Scholar]
  10. Hoffman P. G., Siiteri P. K. Sex steroid receptors in gynecologic cancer. Obstet Gynecol. 1980 May;55(5):648–652. [PubMed] [Google Scholar]
  11. Hunter R. E., Longcope C., Jordan V. C. Steroid hormone receptors in adenocarcinoma of the endometrium. Gynecol Oncol. 1980 Oct;10(2):152–161. doi: 10.1016/0090-8258(80)90077-3. [DOI] [PubMed] [Google Scholar]
  12. Jänne O., Kauppila A., Kontula K., Syrjälä P., Vihko R. Female sex steroid receptors in normal, hyperplastic and carcinomatous endometrium. The relationship to serum steroid hormones and gonadotropins and changes during medroxyprogesterone acetate administration. Int J Cancer. 1979 Nov 15;24(5):545–554. doi: 10.1002/ijc.2910240505. [DOI] [PubMed] [Google Scholar]
  13. Katzenellenbogen B. S., Leake R. E. Distribution of the oestrogen-induced protein and of total protein between endometrial and myometrial fractions of the immature and mature rat uterus. J Endocrinol. 1974 Dec;63(3):439–449. doi: 10.1677/joe.0.0630439. [DOI] [PubMed] [Google Scholar]
  14. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  15. Leake R. E., Laing L., Calman K. C., Macbeth F. R., Crawford D., Smith D. C. Oestrogen-receptor status and endocrine therapy of breast cancer: response rates and status stability. Br J Cancer. 1981 Jan;43(1):59–66. doi: 10.1038/bjc.1981.8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Leake R. E., Laing L., McArdle C., Smith D. C. Soluble and nuclear oestrogen receptor status in human breast cancer in relation to prognosis. Br J Cancer. 1981 Jan;43(1):67–71. doi: 10.1038/bjc.1981.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Levy C., Robel P., Gautray J. P., De Brux J., Verma U., Descomps B., Baulieu E. E. Estradiol and progesterone receptors in human endometrium: normal and abnormal menstrual cycles and early pregnancy. Am J Obstet Gynecol. 1980 Mar 1;136(5):646–651. doi: 10.1016/0002-9378(80)91018-2. [DOI] [PubMed] [Google Scholar]
  18. Pollow K., Lübbert H., Boquoi E., Kreuzer G., Pollow B. Characterization and comparison of receptors for 17 beta-estradiol and progesterone in human proliferative endometrium and endometrial carcinoma. Endocrinology. 1975 Feb;96(2):319–328. doi: 10.1210/endo-96-2-319. [DOI] [PubMed] [Google Scholar]
  19. Prodi G., De Giovanni C., Galli M. C., Gola G., Grilli S., Rocchetta R., Orlandi C. 17 beta-estradiol, 5 alpha-dihydrotestosterone, progesterone and cortisol receptors in normal and neoplastic human endometrium. Tumori. 1979 Apr 30;65(2):241–253. doi: 10.1177/030089167906500214. [DOI] [PubMed] [Google Scholar]
  20. Silfverswärd C., Skoog L., Humla S., Gustafsson S. A., Nordenskjöld B. Intratumoral variation of cytoplasmic and nuclear estrogen receptor concentrations in human mammary carcinoma. Eur J Cancer. 1980 Jan;16(1):59–65. doi: 10.1016/0014-2964(80)90108-5. [DOI] [PubMed] [Google Scholar]
  21. Soutter W. P., Hamilton K., Leake R. E. High affinity binding of oestradiol-17 beta in the nuclei of human endometrial cells. J Steroid Biochem. 1979 May;10(5):529–534. doi: 10.1016/0022-4731(79)90215-2. [DOI] [PubMed] [Google Scholar]
  22. Thorsen T. Occupied and unoccupied nuclear oestradiol receptor in human breast tumours: relation to oestradiol and progesterone cytosol receptors. J Steroid Biochem. 1979 Jun;10(6):661–668. [PubMed] [Google Scholar]
  23. Tilley W. D., Keightley D. D., Cant E. L. Inter-site variation of oestrogen receptors in human breast cancers. Br J Cancer. 1978 Oct;38(4):544–546. doi: 10.1038/bjc.1978.242. [DOI] [PMC free article] [PubMed] [Google Scholar]

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