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. 1983 Apr;47(4):503–509. doi: 10.1038/bjc.1983.80

The mode of action of cis dichloro-bis (isopropylamine) trans dihydroxy platinum IV (CHIP) studied by the analysis of chromosome aberration production.

E Bocian, M Laverick, A H Nias
PMCID: PMC2011329  PMID: 6849795

Abstract

The induction of chromosome damage by the Platinum complex CHIP in Chinese hamster ovary (CHO) cells has been studied, together with the relationship between cell survival and aberration frequency. The type and frequency of chromosome aberrations observed in asynchronous and G1 phase treated cells indicated a similar mode of action to that of bifunctional alkylating agents. A log-linear relationship was observed between the frequency of chromatid aberrations (excluding gaps) and the level of survival after CHIP treatment, with approximately one aberration per cell corresponding to 37% survival.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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