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. 1983 May;47(5):707–712. doi: 10.1038/bjc.1983.109

Incidence of familial Hodgkin's disease.

L Kerzin-Storrar, M J Faed, J B MacGillivray, P G Smith
PMCID: PMC2011375  PMID: 6849804

Abstract

The family histories of 131 patients with histologically defined Hodgkin's disease (HD) were studied and 2,517 first and second degree relatives and spouses were identified and followed-up. The causes of death in deceased relatives were ascertained from death certificates. The numbers of deaths from selected causes were compared with the numbers that would be expected if the relatives had suffered the same mortality rates as the Scottish national population. A 4-fold increase in deaths due to HD was found among first and second degree relatives of patients with the disease (6 cases observed compared with 1.4 expected). Five of the 6 familial cases were related to index patients with the mixed cellularity form of the disease, the remaining case was the brother of a patient with the lymphocyte-depleted form of the disease. The increased risk was seen among relatives of both young and older patients and there was no consistent intrafamilial similarity in age of onset or time of onset of disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abramson J. H., Pridan H., Sacks M. I., Avitzour M., Peritz E. A case-control study of Hodgkin's disease in Israel. J Natl Cancer Inst. 1978 Aug;61(2):307–314. [PubMed] [Google Scholar]
  2. Bowers T. K., Moldow C. F., Bloomfield C. D., Yunis E. J. Familial Hodgkin's disease and the major histocompatibility complex. Vox Sang. 1977;33(5):273–277. doi: 10.1111/j.1423-0410.1977.tb04474.x. [DOI] [PubMed] [Google Scholar]
  3. Buehler S. K., Firme F., Fodor G., Fraser G. R., Marshall W. H., Vaze P. Common variable immunodeficiency, Hodgkin's disease, and other malignancies in a Newfoundland family. Lancet. 1975 Jan 25;1(7900):195–197. doi: 10.1016/s0140-6736(75)91361-6. [DOI] [PubMed] [Google Scholar]
  4. Cole P., MacMahon B., Aisenberg A. Mortality from Hodgkin's disease in the United States. Evidence for the multiple-aetiology hypothesis. Lancet. 1968 Dec 28;2(7583):1371–1376. doi: 10.1016/s0140-6736(68)92675-5. [DOI] [PubMed] [Google Scholar]
  5. Grufferman S., Cole P., Smith P. G., Lukes R. J. Hodgkin's disease in siblings. N Engl J Med. 1977 Feb 3;296(5):248–250. doi: 10.1056/NEJM197702032960504. [DOI] [PubMed] [Google Scholar]
  6. Gutensohn N., Cole P. Childhood social environment and Hodgkin's disease. N Engl J Med. 1981 Jan 15;304(3):135–140. doi: 10.1056/NEJM198101153040302. [DOI] [PubMed] [Google Scholar]
  7. Gutensohn N., Cole P. Epidemiology of hodgkin's disease in the young. Int J Cancer. 1977 May 15;19(5):595–604. doi: 10.1002/ijc.2910190502. [DOI] [PubMed] [Google Scholar]
  8. Harris R. E., Baehner R. L., Gleiser S., Weaver D. D., Hodes M. E. Cartilage-hair hypoplasia, defective T-cell function, and Diamond-Blackfan anemia in an Amish child. Am J Med Genet. 1981;8(3):291–297. doi: 10.1002/ajmg.1320080306. [DOI] [PubMed] [Google Scholar]
  9. Hull P. J., Delamore I. W. Familial Hodgkin's disease. Postgrad Med J. 1978 Oct;54(636):676–677. doi: 10.1136/pgmj.54.636.676. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Marshall W. H., Barnard J. M., Buehler S. K., Crumley J., Larsen B. HLA in familial Hodgkin's disease. Results and a new hypothesis;. Int J Cancer. 1977 Apr 15;19(4):450–455. doi: 10.1002/ijc.2910190403. [DOI] [PubMed] [Google Scholar]
  11. McBride A., Fennelly J. J. Immunological depletion contributing to familial Hodgkin's disease. Eur J Cancer. 1977 Jun;13(6):549–554. doi: 10.1016/0014-2964(77)90116-5. [DOI] [PubMed] [Google Scholar]
  12. Paffenbarger R. S., Jr, Wing A. L., Hyde R. T. Characteristics in youth predictive of adult-onset malignant lymphomas, melanomas, and leukemias: brief communication. J Natl Cancer Inst. 1978 Jan;60(1):89–92. doi: 10.1093/jnci/60.1.89. [DOI] [PubMed] [Google Scholar]
  13. RAZIS D. V., DIAMOND H. D., CRAVER L. F. Familial Hodgkin's disease: its significance and implications. Ann Intern Med. 1959 Nov;51:933–971. doi: 10.7326/0003-4819-51-5-933. [DOI] [PubMed] [Google Scholar]
  14. Thompson E. A. Pedigree analysis of Hodgkin's disease in a Newfoundland genealogy. Ann Hum Genet. 1981 Jul;45(Pt 3):279–292. doi: 10.1111/j.1469-1809.1981.tb00339.x. [DOI] [PubMed] [Google Scholar]

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