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. 1983 May;47(5):629–640. doi: 10.1038/bjc.1983.101

The association of cytosol oestrogen and progesterone receptors with histological features of breast cancer and early recurrence of disease.

J M Howat, D M Barnes, M Harris, R Swindell
PMCID: PMC2011376  PMID: 6849801

Abstract

Two hundred and eighty-eight primary breast tumours were examined for the presence or absence of oestrogen (REc) and progesterone (RPc) receptors. Analysis has shown a relative interdependence between the steroid receptor status of primary breast cancer and other prognostic variables such as histological grade, lymphocytic infiltration and tumour elastosis. There were significant associations between epithelial cellularity, stromal fibrosis and the value of REc in those tumours in which the receptor was present. Cellularity and fibrosis were unrelated to the presence or absence of oestrogen receptor. By contrast, neither the presence or absence nor the value of RPc could be related to cellularity or fibrosis. The value of REc and RPc analysis as an indicator of prognosis was examined in a sub-group of 175 patients receiving no additional treatment following mastectomy. Overall relapse-free survival (RFS) was no different for those patients with receptors compared to those without them (REc P = 0.11, RPc P = 0.7). There was no difference in RFS of receptor positive and negative tumours when the axillary node status was taken into account.

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Selected References

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  1. Allegra J. C., Lippman M. E., Simon R., Thompson E. B., Barlock A., Green L., Huff K. K., Do H. M., Aitken S. C., Warren R. Association between steroid hormone receptor status and disease-free interval in breast cancer. Cancer Treat Rep. 1979 Aug;63(8):1271–1277. [PubMed] [Google Scholar]
  2. Antoniades K., Spector H. Correlation of estrogen receptor levels with histology and cytomorphology in human mammary cancer. Am J Clin Pathol. 1979 May;71(5):497–503. doi: 10.1093/ajcp/71.5.497. [DOI] [PubMed] [Google Scholar]
  3. Aspegren K., Håkansson L. Human mammary carcinoma studied for hormone responsiveness in short term incubations. Acta Chir Scand. 1974;140(2):95–99. [PubMed] [Google Scholar]
  4. BLOOM H. J., RICHARDSON W. W. Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer. 1957 Sep;11(3):359–377. doi: 10.1038/bjc.1957.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Barnes D. M., Ribeiro G. G., Skinner L. G. Two methods for measurement of oestradiol-17 beta and progesterone receptors in human breast cancer and correlation with response treatment. Eur J Cancer. 1977 Oct;13(10):1133–1143. doi: 10.1016/0014-2964(77)90012-3. [DOI] [PubMed] [Google Scholar]
  6. Bishop H. M., Blamey R. W., Elston C. W., Haybittle J. L., Nicholson R. I., Griffiths K. Relationship of oestrogen-receptor status to survival in breast cancer. Lancet. 1979 Aug 11;2(8137):283–284. doi: 10.1016/s0140-6736(79)90295-2. [DOI] [PubMed] [Google Scholar]
  7. Cooke T., George D., Shields R., Maynard P., Griffiths K. Oestrogen receptors and prognosis in early breast cancer. Lancet. 1979 May 12;1(8124):995–997. doi: 10.1016/s0140-6736(79)92752-1. [DOI] [PubMed] [Google Scholar]
  8. Cooke T., George W. D., Griffiths K. Possible test for selection of adjuvant systemic therapy in early cancer of the breast. Br J Surg. 1980 Oct;67(10):747–750. doi: 10.1002/bjs.1800671018. [DOI] [PubMed] [Google Scholar]
  9. Croton R., Cooke T., Holt S., George W. D., Nicolson R., Griffiths K. Oestrogen receptors and survival in early breast cancer. Br Med J (Clin Res Ed) 1981 Nov 14;283(6302):1289–1291. doi: 10.1136/bmj.283.6302.1289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Eusebi V., Betts C. M., Bussolati G. Tubular carcinoma: a variant of secretory breast carcinoma. Histopathology. 1979 Sep;3(5):407–419. doi: 10.1111/j.1365-2559.1979.tb03022.x. [DOI] [PubMed] [Google Scholar]
  11. Feherty P., Farrer-Brown G., Kellie A. E. Oestradiol receptors in carcinoma and benign disease of the breast: an in vitro assay. Br J Cancer. 1971 Dec;25(4):697–710. doi: 10.1038/bjc.1971.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Fisher E. R., Gregorio R. M., Fisher B., Redmond C., Vellios F., Sommers S. C. The pathology of invasive breast cancer. A syllabus derived from findings of the National Surgical Adjuvant Breast Project (protocol no. 4). Cancer. 1975 Jul;36(1):1–85. doi: 10.1002/1097-0142(197507)36:1<1::aid-cncr2820360102>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  13. Forrest A. P., Black R. B., Humeniuk V., Cant E. L., Hawkins R. A., Prescott R. J., Roberts M. M., Shivas A. A., Stewart H. J., Smith A. F. Preoperative assessment and staging of breast cancer: preliminary communication. J R Soc Med. 1980 Aug;73(8):561–566. doi: 10.1177/014107688007300805. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hilf R., Feldstein M. L., Gibson S. L., Savlov E. D. The relative importance of estrogen receptor analysis as a prognostic factor for recurrence or response to chemotherapy in women with breast cancer. Cancer. 1980 Apr 15;45(8):1993–2000. doi: 10.1002/1097-0142(19800415)45:8<1993::aid-cncr2820450802>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  15. Hähnel R., Woodings T., Vivian A. B. Prognostic value of estrogen receptors in primary breast cancer. Cancer. 1979 Aug;44(2):671–675. doi: 10.1002/1097-0142(197908)44:2<671::aid-cncr2820440238>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  16. Johansson H., Terenius L., Thorén L. The binding of estradiol-17beta to human breast cancers and other tissues in vitro. Cancer Res. 1970 Mar;30(3):692–698. [PubMed] [Google Scholar]
  17. King R. J., Barnes D. M., Hawkins R. A., Leake R. E., Maynard P. V., Roberts M. M. Measurement of oestradiol receptors by five institutions on common tissue samples. Br J Cancer. 1978 Sep;38(3):428–430. doi: 10.1038/bjc.1978.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kinne D. W., Ashikari R., Butler A., Menendez-Botet C., Rosen P. P., Schwartz M. Estrogen receptor protein in breast cancer as a predictor of recurrence. Cancer. 1981 May 15;47(10):2364–2367. doi: 10.1002/1097-0142(19810515)47:10<2364::aid-cncr2820471007>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  19. Knight W. A., Livingston R. B., Gregory E. J., McGuire W. L. Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer. Cancer Res. 1977 Dec;37(12):4669–4671. [PubMed] [Google Scholar]
  20. Korenman S. G., Dukes B. A. Specific estrogen binding by the cytoplasm fof human breast carcinoma. J Clin Endocrinol Metab. 1970 May;30(5):639–645. doi: 10.1210/jcem-30-5-639. [DOI] [PubMed] [Google Scholar]
  21. Leclercq G., Heuson J. C., Schoenfeld R., Mattheiem W. H., Tagnon H. J. Estrogen receptors in human breast cancer. Eur J Cancer. 1973 Sep;9(9):665–673. doi: 10.1016/0014-2964(73)90009-1. [DOI] [PubMed] [Google Scholar]
  22. Martin P. M., Rolland P. H., Jacquemier J., Rolland A. M., Toga M. Multiple steroid receptors in human breast cancer. II. Estrogen and progestin receptors in 672 primary tumors. Cancer Chemother Pharmacol. 1979;2(2):107–113. doi: 10.1007/BF00254082. [DOI] [PubMed] [Google Scholar]
  23. Martin P. M., Rolland P. H., Jacquemier J., Rolland A. M., Toga M. Multiple steroid receptors in human breast cancer. III. Relationships between steroid receptors and the state of differentiation and the activity of carcinomas throughout the pathologic features. Cancer Chemother Pharmacol. 1979;2(2):115–120. doi: 10.1007/BF00254083. [DOI] [PubMed] [Google Scholar]
  24. Masters J. R., Hawkins R. A., Sangster K., Hawkins W., Smith I. I., Shivas A. A., Roberts M. M., Forrest A. P. Oestrogen receptors, cellularity, elastosis and menstrual status in human breast cancer. Eur J Cancer. 1978 Mar;14(3):303–307. doi: 10.1016/0014-2964(78)90194-9. [DOI] [PubMed] [Google Scholar]
  25. Masters J. R., Millis R. R., King R. J., Rubens R. D. Elastosis and response to endocrine therapy in human breast cancer. Br J Cancer. 1979 May;39(5):536–539. doi: 10.1038/bjc.1979.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Masters J. R., Sangster K., Hawkins R. A., Shivas A. A. Elastosis and oestrogen receptors in human breast cancer. Br J Cancer. 1976 Mar;33(3):342–343. doi: 10.1038/bjc.1976.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Maynard P. V., Blamey R. W., Elston C. W., Haybittle J. L., Griffiths K. Estrogen receptor assay in primary breast cancer and early recurrence of the disease. Cancer Res. 1978 Nov;38(11 Pt 2):4292–4295. [PubMed] [Google Scholar]
  28. Maynard P. V., Davies C. J., Blamey R. W., Elston C. W., Johnson J., Griffiths K. Relationship between oestrogen-receptor content and histological grade in human primary breast tumours. Br J Cancer. 1978 Dec;38(6):745–748. doi: 10.1038/bjc.1978.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. McGuire W. L., Horwitz K. B., Pearson O. H., Segaloff A. Current status of estrogen and progesterone receptors in breast cancer. Cancer. 1977 Jun;39(6 Suppl):2934–2947. doi: 10.1002/1097-0142(197706)39:6<2934::aid-cncr2820390680>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  30. Millis R. R., Rubens R. D., Masters J. R., Minton M. J. Histological grade and response to endocrine therapy in breast cancer. Lancet. 1981 Jul 11;2(8237):101–101. doi: 10.1016/s0140-6736(81)90459-1. [DOI] [PubMed] [Google Scholar]
  31. Oestrogen receptors and survival in early breast cancer. Br Med J (Clin Res Ed) 1982 Feb 20;284(6315):597–598. doi: 10.1136/bmj.284.6315.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Pichon M. F., Pallud C., Brunet M., Milgrom E. Relationship of presence of progesterone receptors to prognosis in early breast cancer. Cancer Res. 1980 Sep;40(9):3357–3360. [PubMed] [Google Scholar]
  33. Rasmussen B. B., Rose C., Thorpe S. M., Hou-Jensen K., Daehnfeldt J. L., Palshof T. Histopathological characteristics and oestrogen receptor content in primary breast carcinoma. Virchows Arch A Pathol Anat Histol. 1981;390(3):347–351. doi: 10.1007/BF00496564. [DOI] [PubMed] [Google Scholar]
  34. Rolland P. H., Jacquemier J., Martin P. M. Histological differentiation in human breast cancer is related to steroid receptors and stromal elastosis. Cancer Chemother Pharmacol. 1980;5(2):73–77. doi: 10.1007/BF00435407. [DOI] [PubMed] [Google Scholar]
  35. Rosen P. P., Menendez-Botet C. J., Nisselbaum J. S., Urban J. A., Miké V., Fracchia A., Schwartz M. K. Pathological review of breast lesions analyzed for estrogen receptor protein. Cancer Res. 1975 Nov;35(11 Pt 1):3187–3194. [PubMed] [Google Scholar]
  36. Samaan N. A., Buzdar A. U., Aldinger K. A., Schultz P. N., Yang K. P., Romsdahl M. M., Martin R. Estrogen receptor: a prognostic factor in breast cancer. Cancer. 1981 Feb 1;47(3):554–560. doi: 10.1002/1097-0142(19810201)47:3<554::aid-cncr2820470322>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  37. Sander S. The in vitro uptake of oestradiol in biopsies from 25 breast cancer patients. Acta Pathol Microbiol Scand. 1968;74(2):301–302. doi: 10.1111/j.1699-0463.1968.tb03481.x. [DOI] [PubMed] [Google Scholar]
  38. Say C. C., Donegan W. L. Invasive carcinoma of the breast: prognostic significance of tumor size and involved axillary lymph nodes. Cancer. 1974 Aug;34(2):468–471. doi: 10.1002/1097-0142(197408)34:2<468::aid-cncr2820340235>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  39. Shivas A. A., Douglas J. G. The prognostic significance of elastosis in breast carcinoma. J R Coll Surg Edinb. 1972 Sep;17(5):315–320. [PubMed] [Google Scholar]
  40. Silverstrini R., Daidone M. G., Di Fronzo G. Relationship between proliferative activity and estrogen receptors in breast cancer. Cancer. 1979 Aug;44(2):665–670. doi: 10.1002/1097-0142(197908)44:2<665::aid-cncr2820440237>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  41. Skinner L. G., Barnes D. M., Ribeiro G. G. The clinical value of multiple steroid receptor assays in breast cancer management. Cancer. 1980 Dec 15;46(12 Suppl):2939–2945. doi: 10.1002/1097-0142(19801215)46:12+<2939::aid-cncr2820461440>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  42. Terenius L., Johansson H., Rimsten A., Thorén L. Malignant and benign human mammary disease: estrogen binding in relation to clinical data. Cancer. 1974 May;33(5):1364–1368. doi: 10.1002/1097-0142(197405)33:5<1364::aid-cncr2820330522>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  43. Thoresen S., Tangen M., Støa K. F., Hartveit F. Oestrogen receptor values and histological grade in human breast cancer. Histopathology. 1981 May;5(3):257–262. doi: 10.1111/j.1365-2559.1981.tb01784.x. [DOI] [PubMed] [Google Scholar]
  44. Westerberg H., Gustafson S. A., Nordenskjöld B., Silfverswärd C., Wallgren A. Estrogen receptor level and other factors in early recurrence of breast cancer. Int J Cancer. 1980 Oct 15;26(4):429–433. doi: 10.1002/ijc.2910260407. [DOI] [PubMed] [Google Scholar]
  45. Wittliff J. L., Hilf R., Brooks W. F., Jr, Savlov E. D., Hall T. C., Orlando R. A. Specific estrogen-binding capacity of the cytoplasmic receptor in normal and neoplastic breast tissues of humans. Cancer Res. 1972 Sep;32(9):1983–1992. [PubMed] [Google Scholar]
  46. von Maillot K., Horke W., Prestele H. Prognostic significance of the steroid receptor content in primary breast cancer. Arch Gynecol. 1982;231(3):185–190. doi: 10.1007/BF02110117. [DOI] [PubMed] [Google Scholar]

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