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. 1983 Aug;48(2):185–193. doi: 10.1038/bjc.1983.174

The incidence of B cell leukaemia and lymphopenia in B cell neoplasia in adults: a study using the Kiel classification of non-Hodgkin's lymphoma.

A Cader, P Richardson, L Walsh, N R Ling, I C MacLennan, E L Jones, M Leyland
PMCID: PMC2011432  PMID: 6603860

Abstract

The incidence of B cell leukaemia in 186 consecutive untreated patients with histologically defined B cell neoplasms is described. The lymphomas were classified by the Kiel convention. B cell leukaemia in the context of this paper refers to the situation where a neoplastic clone of B cells in the blood greatly outnumbers normal blood B cells. It is defined as an absolute blood B cell count greater than 0.75 X 10(9)1(-1) where either greater than 90% B cells express kappa immunoglobulin light chains or greater than 80% express lambda light chains. This was found in several patients where the total blood lymphocyte count was within normal limits. All patients with diffuse lymphocytic lymphoma with the histological appearances of B cell chronic lymphocytic leukaemia (ML-BCLL) were found to have B cell leukaemia. However, more than half these patients had blood B cell counts less than 10 X 10(9)1(-1). B cell leukaemia was also a feature in approximately 33% of patients with follicle centre cell tumours and 33% of those with lymphoplasmacytoid tumours. B cell leukaemia was not detected in 34/35 patients with myelomatosis. The 35th patient had plasma cell leukaemia. Only 3/22 patients with high grade lymphoma had B cell leukaemia. In the three principal tumour types associated with B cell leukaemia mu + delta was the most common immunoglobulin heavy chain phenotype. Spontaneous mouse red cell rosette formation also characterised leukaemic B cells in these three groups but high proportions of mouse rosetting cells were seen only in association with ML-BCLL. None of 4 cases of prolymphocytic leukaemia showed mouse red cell rosetting. HLA-DR alpha chain was found on the leukaemic cells of all patients except one with ML-BCLL. B cell lymphopenia was a frequent finding in all histological groups in those patients who did not have B cell leukaemia.

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Selected References

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  1. Ballet J. J., Fellous M., Sharon N., Reisner Y., Agrapart M. Reactivity of human lymphoid and lymphoblastoid cells with peanut agglutinin: detection of a blood cell subset which lacks detectable membrane HLA. Scand J Immunol. 1980;11(5):555–560. doi: 10.1111/j.1365-3083.1980.tb00024.x. [DOI] [PubMed] [Google Scholar]
  2. Bentwich Z., Douglas S. D., Skutelsky E., Kunkel H. G. Sheep red cell binding to human lymphocytes treated with neuraminidase; enhancement of T cell binding and identification of a subpopulation of B cells. J Exp Med. 1973 Jun 1;137(6):1532–1537. doi: 10.1084/jem.137.6.1532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Beverley P. C., Callard R. E. Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. Eur J Immunol. 1981 Apr;11(4):329–334. doi: 10.1002/eji.1830110412. [DOI] [PubMed] [Google Scholar]
  4. Burns G. F., Worman C. P., Roberts B. E., Raper C. G., Barker C. R., Cawley J. C. Terminal B cell development as seen in different human myelomas and related disorders. Clin Exp Immunol. 1979 Feb;35(2):180–189. [PMC free article] [PubMed] [Google Scholar]
  5. Catovsky D., Cherchi M., Okos A., Hegde U., Galton D. A. Mouse red-cell rosettes in B-lymphoproliferative disorders. Br J Haematol. 1976 Jun;33(2):173–177. doi: 10.1111/j.1365-2141.1976.tb03528.x. [DOI] [PubMed] [Google Scholar]
  6. Catovsky D., Pittman S., O'Brien M., Cherchi M., Costello C., Foa R., Pearce E., Hoffbrand A. V., Janossy G., Ganeshaguru K. Multiparameter studies in lymphoid leukemias. Am J Clin Pathol. 1979 Oct;72(4 Suppl):736–745. [PubMed] [Google Scholar]
  7. Dhaliwal H. S., Ling N. R., Bishop S., Chapel H. Expression of immunoglobin G on blood lymphocytes in chronic lymphocytic leukaemia. Clin Exp Immunol. 1978 Feb;31(2):226–236. [PMC free article] [PubMed] [Google Scholar]
  8. Dillman R. O., Royston I., Meserve B. L., Griffiths J. C. Alterations of peripheral blood B-lymphocyte populations in plasma cell disorders. Cancer. 1981 Nov 15;48(10):2211–2217. doi: 10.1002/1097-0142(19811115)48:10<2211::aid-cncr2820481016>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  9. Gajl-Peczalska K. J., Bloomfield C. D., Coccia P. F., Sosin H., Brunning R. D., Kersey J. H. B and T cell lymphomas. Analysis of blood and lymph nodes in 87 patients. Am J Med. 1975 Nov;59(5):674–685. doi: 10.1016/0002-9343(75)90228-4. [DOI] [PubMed] [Google Scholar]
  10. Galton D. A., Catovsky D., Wiltshaw E. Clinical spectrum of lymphoproliferative diseases. Cancer. 1978 Aug;42(2 Suppl):901–910. doi: 10.1002/1097-0142(197808)42:2+<901::aid-cncr2820420712>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  11. Galton D. A., MacLennan I. C. Clinical patterns in B lymphoid malignancy. Clin Haematol. 1982 Oct;11(3):561–587. [PubMed] [Google Scholar]
  12. Garrett J. V., Scarffe J. H., Newton R. K. Abnormal peripheral blood lymphocytes and bone marrow infiltration in non-Hodgkin's lymphoma. Br J Haematol. 1979 May;42(1):41–50. doi: 10.1111/j.1365-2141.1979.tb03696.x. [DOI] [PubMed] [Google Scholar]
  13. Howard J. C. The life-span and recirculation of marrow-derived small lymphocytes from the rat thoracic duct. J Exp Med. 1972 Feb 1;135(2):185–199. doi: 10.1084/jem.135.2.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kaplan M. E., Clark C. An improved rosetting assay for detection of human T lymphocytes. J Immunol Methods. 1974 Jul;5(2):131–135. doi: 10.1016/0022-1759(74)90003-9. [DOI] [PubMed] [Google Scholar]
  15. Klaus G. G., Humphrey J. H., Kunkl A., Dongworth D. W. The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory. Immunol Rev. 1980;53:3–28. doi: 10.1111/j.1600-065x.1980.tb01038.x. [DOI] [PubMed] [Google Scholar]
  16. Koziner B., Filippa D. A., Mertelsmann R., Gupta S., Clarkson B., Good R. A., Siegal F. P. Characterization of malignant lymphomas in leukemic phase by multiple differentiation markers of mononuclear cells. Correlations with clinical features and conventional morphology. Am J Med. 1977 Oct;63(4):556–567. doi: 10.1016/0002-9343(77)90201-7. [DOI] [PubMed] [Google Scholar]
  17. Koziner B., Kempin S., Passe S., Gee T., Good R. A., Clarkson B. D. Characterization of B-cell leukemias: a tentative immunomorphological scheme. Blood. 1980 Nov;56(5):815–823. [PubMed] [Google Scholar]
  18. Leonard R. C., MacLennan I. C., Smart Y., Vanhegan R. I., Cuzick J. Light chain isotype-associated suppression of normal plasma cell numbers in patients with multiple myeloma: Medical Research Council's Working Party for Leukaemia in Adults and the Oxford Lymphoma Group. Int J Cancer. 1979 Oct 15;24(4):385–393. doi: 10.1002/ijc.2910240402. [DOI] [PubMed] [Google Scholar]
  19. Levin S., Russell E. C., Blanchard D., McWilliams N. B., Maurer H. M., Mohanakumar T. Receptors for peanut agglutinin (Arachus hypogea) in childhood acute lymphoblastic leukemia: possible clinical significance. Blood. 1980 Jan;55(1):37–39. [PubMed] [Google Scholar]
  20. Lowe J., Hardie D., Jefferis R., Ling N. R., Drysdale P., Richardson P., Raykundalia C., Catty D., Appleby P., Drew R. Properties of monoclonal antibodies to human immunoglobulin kappa and lambda chains. Immunology. 1981 Apr;42(4):649–659. [PMC free article] [PubMed] [Google Scholar]
  21. Mellstedt H., Holm G., Pettersson D., Peest D. Idiotype-bearing lymphoid cells in plasma cell neoplasia. Clin Haematol. 1982 Feb;11(1):65–86. [PubMed] [Google Scholar]
  22. O'Keefe D., Ashman L. Peanut agglutinin: a marker for normal and leukaemic cells of the monocyte lineage. Clin Exp Immunol. 1982 May;48(2):329–338. [PMC free article] [PubMed] [Google Scholar]
  23. Pettersson D., Mellstedt H., Holm G. Immunoglobulin isotypes on monoclonal blood lymphocytes in human plasma cell myeloma. J Clin Lab Immunol. 1980 Mar;3(2):93–98. [PubMed] [Google Scholar]
  24. Pettersson D., Mellstedt H., Holm G. Monoclonal B lymphocytes in multiple myeloma. Scand J Immunol. 1980;12(5):375–382. doi: 10.1111/j.1365-3083.1980.tb00081.x. [DOI] [PubMed] [Google Scholar]
  25. Preud'homme J. L., Klein M., Labaume S., Seligmann M. Idiotype-bearing and antigen-binding receptors produced by blood T lymphocytes in a case of human myeloma. Eur J Immunol. 1977 Dec;7(12):840–846. doi: 10.1002/eji.1830071204. [DOI] [PubMed] [Google Scholar]
  26. Rose M. L., Habeshaw J. A., Kennedy R., Sloane J., Wiltshaw E., Davies A. J. Binding of peanut lectin to germinal-centre cells: a marker for B-cell subsets of follicular lymphoma? Br J Cancer. 1981 Jul;44(1):68–74. doi: 10.1038/bjc.1981.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Rubinstein L. J., Yeh M., Bona C. A. Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the expansion of idiotype-specific helper T cells. J Exp Med. 1982 Aug 1;156(2):506–521. doi: 10.1084/jem.156.2.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Stathopoulos G., Elliott E. V. Formation of mouse or sheep red-blood-cell rosettes by lymphocytes from normal and leukaemic individuals. Lancet. 1974 Apr 6;1(7858):600–601. doi: 10.1016/s0140-6736(74)92655-5. [DOI] [PubMed] [Google Scholar]

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