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. 1983 Oct;48(4):495–505. doi: 10.1038/bjc.1983.222

Enzymic retrodifferentiation during hepatocarcinogenesis and liver regeneration in rats in vivo.

N J Curtin, K Snell
PMCID: PMC2011495  PMID: 6626450

Abstract

The work presented here has concerned the study of early, as well as late, enzymic changes occurring during diethylnitrosamine-induced hepatocarcinogenesis and liver regeneration after partial hepatectomy in comparison with normal liver differentiation. Rank correlation analysis of the enzyme data suggested a step-wise retrodifferentiation i.e. that the liver during carcinogenesis first assumed a neonatal enzymic pattern before attaining a foetal enzymic state. Similar enzymic changes were observed in regenerating liver after partial hepatectomy; again there was a step-wise retrodifferentiation of enzymic pattern and at 3 days post hepatectomy the liver had an enzymic pattern similar to both foetal and neoplastic liver. However, in contrast to liver undergoing neoplastic change, the regenerating liver retained the capacity to undergo redifferentiation towards a normal adult biochemical pattern.

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Selected References

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  1. Abelev G. I. Alpha-fetoprotein in ontogenesis and its association with malignant tumors. Adv Cancer Res. 1971;14:295–358. doi: 10.1016/s0065-230x(08)60523-0. [DOI] [PubMed] [Google Scholar]
  2. Ballard F. J., Hanson R. W. Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver. Biochem J. 1967 Sep;104(3):866–871. doi: 10.1042/bj1040866. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Criss W. E. A review of isozymes in cancer. Cancer Res. 1971 Nov;31(11):1523–1542. [PubMed] [Google Scholar]
  4. Enomoto K., Dempo K., Mori M., Onoé T. Histopathological and ultrastructural study on extramedullary hematopoietic foci in early stage of 3'-methyl-4-(dimethylamino)azobenzene hepatocarcinogenesis. Gan. 1978 Apr;69(2):249–254. [PubMed] [Google Scholar]
  5. Greengard O. Enzymic differentiation in mammalian tissues. Essays Biochem. 1971;7:159–205. [PubMed] [Google Scholar]
  6. Herzfeld A., Greengard O. Aspartate aminotransferase in fat tissues: changes with growth and hormones. Biochim Biophys Acta. 1971 Apr 20;237(1):88–98. doi: 10.1016/0304-4165(71)90033-x. [DOI] [PubMed] [Google Scholar]
  7. Herzfeld A. The distribution of glutamate dehydrogenase in rat tissues. Enzyme. 1972;13(4):246–251. doi: 10.1159/000459668. [DOI] [PubMed] [Google Scholar]
  8. Ichihara A. Isozyme patterns of branched-chain amino acid transaminase during cellular differentiation and carcinogenesis. Ann N Y Acad Sci. 1975 Aug 22;259:347–354. doi: 10.1111/j.1749-6632.1975.tb25431.x. [DOI] [PubMed] [Google Scholar]
  9. Idéo G., Del Ninno E., De Franchis R. Behaviour of some enzymes and isoenzymes in plasma liver and bile of rats treated with carbon tetrachloride. Enzyme. 1971;12(2):242–254. doi: 10.1159/000459537. [DOI] [PubMed] [Google Scholar]
  10. Katz N. Correlation between rates and enzyme levels of increased gluconeogenesis in rat liver and kidney after partial hepatectomy. Eur J Biochem. 1979 Aug 1;98(2):535–542. doi: 10.1111/j.1432-1033.1979.tb13214.x. [DOI] [PubMed] [Google Scholar]
  11. Pierce G. B. Differentiation of normal and malignant cells. Fed Proc. 1970 May-Jun;29(3):1248–1254. [PubMed] [Google Scholar]
  12. Reid E. Specificity of certain biochemical derangements in hepatocarcinogenesis. Br J Cancer. 1970 Mar;24(1):128–137. doi: 10.1038/bjc.1970.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SHARMA C., MANJESHWAR R., WEINHOUSE S. EFFECTS OF DIET AND INSULIN ON GLUCOSE-ADENOSINE TRIPHOSPHATE PHOSPHOTRANSFERASES OF RAT LIVER. J Biol Chem. 1963 Dec;238:3840–3845. [PubMed] [Google Scholar]
  14. Schapira F. Isozymes and cancer. Adv Cancer Res. 1973;18:77–153. doi: 10.1016/s0065-230x(08)60751-4. [DOI] [PubMed] [Google Scholar]
  15. Uriel J. Cancer, retrodifferentiation, and the myth of Faust. Cancer Res. 1976 Nov;36(11 Pt 2):4269–4275. [PubMed] [Google Scholar]
  16. Uriel J. Retrodifferentiation and the fetal patterns of gene expression in cancer. Adv Cancer Res. 1979;29:127–174. doi: 10.1016/s0065-230x(08)60847-7. [DOI] [PubMed] [Google Scholar]
  17. Walker P. R., Potter V. R. Isozyme studies on adult, regenerating, precancerous and developing liver in relation to findings in hepatomas. Adv Enzyme Regul. 1972;10:339–364. doi: 10.1016/0065-2571(72)90022-2. [DOI] [PubMed] [Google Scholar]
  18. Weber G., Shiotani T., Kizaki H., Tzeng D., Williams J. C., Gladstone N. Biochemical strategy of the genome as expressed in regulation of pyrimidine metabolism. Adv Enzyme Regul. 1977 Oct 3;16:3–19. doi: 10.1016/0065-2571(78)90064-x. [DOI] [PubMed] [Google Scholar]

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