Abstract
The effects of systemically administered oxytetracycline and erythromycin in a guinea pig model of acne-type inflammation were assessed histologically and by tissue measurement techniques. It was found that oxytetracycline significantly reduced the volume and maximum area of inflammation compared with both control and erythromycin treated groups. Oxytetracycline also altered the morphology of the inflammatory infiltrate significantly reducing the proportion of polymorphonuclear leucocytes present. In this model, erythromycin did not alter the inflammatory response but did seem to reduce the amount of transepidermal elimination of inflammatory debris.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bayoumi A. H., Marks R. Transepidermal elimination: studies with an animal model. Br J Exp Pathol. 1980 Dec;61(6):560–566. [PMC free article] [PubMed] [Google Scholar]
- Cunliffe W. J., Forster R. A., Greenwood N. D., Hetherington C., Holland K. T., Holmes R. L., Khan S., Roberts C. D., Williams M., Williamson B. Tetracycline and acne vulgaris: a clinical and laboratory investigation. Br Med J. 1973 Nov 10;4(5888):332–335. doi: 10.1136/bmj.4.5888.332. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Esterly N. B., Furey N. L., Flanagan L. E. The effect of antimicrobial agents on leukocyte chemotaxis. J Invest Dermatol. 1978 Jan;70(1):51–55. doi: 10.1111/1523-1747.ep12543487. [DOI] [PubMed] [Google Scholar]
- Forsgren A., Schmeling D., Quie P. G. Effect of tetracycline on the phagocytic function of human leukocytes. J Infect Dis. 1974 Oct;130(4):412–415. doi: 10.1093/infdis/130.4.412. [DOI] [PubMed] [Google Scholar]