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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1987 Feb;68(1):1–6.

Biliary lipid secretion in the regenerating liver of the rat.

F Pérez-Barriocanal, J González, A Esteller
PMCID: PMC2012997  PMID: 3814495

Abstract

The effect of two-thirds hepatectomy on biliary lipid secretion was studied in fasted rats. Bile acids, cholesterol and phospholipids were determined in the bile of rats with biliary drainage. Bile acid and phospholipid concentrations were not significantly modified during liver regeneration but there was a significant decrease in cholesterol concentrations in bile at 12 h after hepatectomy, with a gradual return to normal values. The molar percentage of cholesterol and the calculated lithogenic index of bile were also significantly decreased by 12 h. The biliary secretion of bile acids and phospholipids, expressed per gram of liver, showed a tendency to increase regeneration, but cholesterol secretion was significantly decreased from 12 to 48 h following liver resection. Some possibilities to explain the uncoupling between cholesterol secretion and bile acid secretion are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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