Abstract
Mice continuously exposed to ethanol vapour (for up to 19 days) developed fatty change in the liver (from 2 days onwards) and lesions resembling those of alcoholic hepatitis in man (from 5 days onwards). They also showed biochemical evidence of liver cell damage. Sera from ethanol-treated animals contained immunoglobulins that bound to the hepatocytes of ethanol-treated but not of control animals suggesting that exposure to ethanol was followed by an immunological response to a hepatocyte neo-antigen. In addition, such sera were cytotoxic in an in-vitro assay, and on Sephacryl S-300 gel filtration the cytotoxic activity eluted together with albumin molecules.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Di Luzio N. R., Stege T. E. Influence of chronic ethanol vapor inhalation on hepatic parenchymal and Kupffer cell function. Alcohol Clin Exp Res. 1979 Jul;3(3):240–247. doi: 10.1111/j.1530-0277.1979.tb05307.x. [DOI] [PubMed] [Google Scholar]
- Griffiths P. J., Littleton J. M., Ortiz A. Changes in monoamine concentrations in mouse brain associated with ethanol dependence and withdrawal. Br J Pharmacol. 1974 Apr;50(4):489–498. doi: 10.1111/j.1476-5381.1974.tb08582.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hall P., Gormley B. M., Jarvis L. R., Smith R. D. A staining method for the detection and measurement of fat droplets in hepatic tissue. Pathology. 1980 Oct;12(4):605–608. doi: 10.3109/00313028009086813. [DOI] [PubMed] [Google Scholar]
- Lieber C. S., DeCarli L., Rubin E. Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets. Proc Natl Acad Sci U S A. 1975 Feb;72(2):437–441. doi: 10.1073/pnas.72.2.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lieber C. S., Rubin E. Ethanol--a hepatotoxic drug. Gastroenterology. 1968 Apr;54(4):642–646. [PubMed] [Google Scholar]
- MacSween R. N., Anthony R. S., Farquharson M. Antibodies to alcohol-altered hepatocytes in patients with alcoholic liver disease. Lancet. 1981 Oct 10;2(8250):803–804. doi: 10.1016/s0140-6736(81)90205-1. [DOI] [PubMed] [Google Scholar]
- Wickramasinghe S. N., Gardner B., Barden G. Cytotoxic protein molecules generated as a consequence of ethanol metabolism in vitro and in vivo. Lancet. 1986 Oct 11;2(8511):823–826. doi: 10.1016/s0140-6736(86)92866-7. [DOI] [PubMed] [Google Scholar]