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. 1986 Dec;67(6):925–935.

The release, tissue distribution and excretion of mercury from experimental amalgam tattoos.

S W Cox, B M Eley
PMCID: PMC2013129  PMID: 3801303

Abstract

Following the subcutaneous implantation of powdered dental amalgam in guinea pigs, there was an initial extrusion of material from the healing implantation wounds. Longer-term release of mercury from the lesions was demonstrated by linear regression analysis of the mercury contents of implant sites removed after time periods of up to 2 years. Raised mercury levels were detected in the blood, bile, kidneys, liver, spleen and lungs of implanted animals; by far the highest concentrations were found in the renal cortex. Mercury was excreted with the urine and, to a lesser extent, the faeces. The pattern of mercury redistribution resembled that seen following chronic exposure to mercuric compounds.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bornmann G., Henke G., Alfes H., Möllmann H. Uber die enterale Resorption von metallischem Quecksilber. Arch Toxikol. 1970;26(3):203–209. [PubMed] [Google Scholar]
  2. Buchner A., Hansen L. S. Amalgam pigmentation (amalgam tattoo) of the oral mucosa. A clinicopathologic study of 268 cases. Oral Surg Oral Med Oral Pathol. 1980 Feb;49(2):139–147. doi: 10.1016/0030-4220(80)90306-0. [DOI] [PubMed] [Google Scholar]
  3. Eley B. M., Cox S. W. The development of mercury- and selenium-containing deposits in the kidneys following implantation of dental amalgams in guinea pigs. Br J Exp Pathol. 1986 Dec;67(6):937–949. [PMC free article] [PubMed] [Google Scholar]
  4. Eley B. M. Tissue reactions to implanted dental amalgam, including assessment by energy dispersive x-ray micro-analysis. J Pathol. 1982 Nov;138(3):251–272. doi: 10.1002/path.1711380307. [DOI] [PubMed] [Google Scholar]
  5. FITZHUGH O. G., NELSON A. A., LAUG E. P., KUNZE F. M. Chronic oral toxicities of mercuri-phenyl and mercuric salts. AMA Arch Ind Hyg Occup Med. 1950 Oct;2(4):433–442. [PubMed] [Google Scholar]
  6. FRIBERG L. Studies on the metabolism of mercuric chloride and methyl mercury dicyandiamide; experiments on rats given subcutaneous injections with radioactive mercury (Hg203). AMA Arch Ind Health. 1959 Jul;20(1):42–49. [PubMed] [Google Scholar]
  7. Harrison J. D., Rowley P. S., Peters P. D. Amalgam tattoos: light and electron microscopy and electron-probe micro-analysis. J Pathol. 1977 Feb;121(2):83–92. doi: 10.1002/path.1711210204. [DOI] [PubMed] [Google Scholar]
  8. Jakubowski M., Piotrowski J., Trojanowska B. Binding of mercury in the rat: studies using 203HgCl2 and gel filtration. Toxicol Appl Pharmacol. 1970 May;16(3):743–753. doi: 10.1016/0041-008x(70)90080-3. [DOI] [PubMed] [Google Scholar]
  9. Kazantzis G. Mercury and the kidney. Trans Soc Occup Med. 1970 Apr;20(2):54–passim. doi: 10.1093/occmed/20.2.54. [DOI] [PubMed] [Google Scholar]
  10. Lindstedt G. A rapid method for the determination of mercury in urine. Analyst. 1970 Mar;95(128):264–271. doi: 10.1039/an9709500264. [DOI] [PubMed] [Google Scholar]
  11. PRICKETT C. S., LAUG E. P., KUNZE F. M. Distribution of mercury in rats following oral and intravenous administration of mercuric acetate and phenylmercuric acetate. Proc Soc Exp Biol Med. 1950 Apr;73(4):585–588. doi: 10.3181/00379727-73-17752. [DOI] [PubMed] [Google Scholar]
  12. ULFVARSON U. Distribution and excretion of some mercury compounds after long term exposure. Int Arch Gewerbepathol Gewerbehyg. 1962 Jul 5;19:412–422. doi: 10.1007/BF00312571. [DOI] [PubMed] [Google Scholar]

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