Abstract
Chronic cystitis due to Escherichia coli is frequently associated with anatomical or functional abnormalities of the lower urinary tract, but there is no satisfactory animal model available to help resolve biological and management problems. We have induced chronic infection of the unobstructed urinary tract in the rat by implanting a small polyurethane sponge into the dome of the bladder, 14 days before bacterial challenge. This manipulation provides a focus of infected urine and leads to the establishment of a chronic cystitis. Both the predisposing factor and the pathological details mimic important features of the disease in man.
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- Lewis R. W., Roberts J. A. The effects of chronic cystitis on vesicoureteral reflux in an animal model. J Urol. 1986 Jan;135(1):182–184. doi: 10.1016/s0022-5347(17)45558-3. [DOI] [PubMed] [Google Scholar]
- Miller T. E., Findon G., Cawley S., Clarke I. Cellular basis of host defence in pyelonephritis. II. Acute infection. Br J Exp Pathol. 1986 Apr;67(2):191–200. [PMC free article] [PubMed] [Google Scholar]
- Nicholson A. M., Glynn A. A. Investigation of the effect of K antigen in Escherichia coli urinary tract infections by use of a mouse model. Br J Exp Pathol. 1975 Dec;56(6):549–553. [PMC free article] [PubMed] [Google Scholar]