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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1986 Apr;67(2):229–233.

Sex related differences in serum gastrin concentrations and G- and D-cell populations of the gastric mucosa in guinea-pigs (experimental RIA and immunocytochemical study).

C Kittas, E Xynos, E Neonakis, A Fountos, K Aroni, J S Vassilakis
PMCID: PMC2013164  PMID: 2871861

Abstract

In the present study antral G-cells which secrete gastrin and antral and fundic D-cells which secret somatostatin, an inhibitor of gastric acid secretion were revealed immunocytochemically and the population size estimated along with serum gastrin levels in ten male and eight female guinea pigs. Serum gastrin, antral G-cells, antral D-cells and fundic D-cells were 41.90 +/- 6.10 SD pg/ml, 210 +/- 18.03 SD cells/cm, 128.20 +/- 17.64 SD cells/cm and 121 +/- 17.91 SD cells/cm respectively in males and 35 +/- 4.62 SD pg/ml, 176 +/- 13.80 SD cells/cm, 108.40 +/- 6.90 SD cells/cm and 106.8 +/- 6.50 SD cells/cm respectively in females. The differences in serum gastrin levels, antral G-cell population and antral D-cell population between the two sexes were statistically significant (P less than 0.05, P less than 0.001, P less than 0.01). It is possible that endogenous androgens induce a relative hyperplasia and endogenous oestrogens a relative hypoplasia of G-cells. Antral D-cell differences may reflect an adaptive hormonal mechanism to the possible different states of gastric secretory functions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnold R., Lankisch P. G. Somatostatin and the gastrointestinal tract. Clin Gastroenterol. 1980 Sep;9(3):733–753. [PubMed] [Google Scholar]
  2. Delaney J. P., Michel H. M., Eisenberg M. M., Bonsack M. Quantitation of antral gastrin cell populations in the dog. Gastroenterology. 1978 Apr;74(4):708–712. [PubMed] [Google Scholar]
  3. GROSSMAN M. I., KIRSNER J. B., GILLESPIE I. E. BASAL AND HISTALOG-STIMULATED GASTRIC SECRETION IN CONTROL SUBJECTS AND IN PATIENTS WITH PEPTIC ULCER OR GASTRIC CANCER. Gastroenterology. 1963 Jul;45:14–26. [PubMed] [Google Scholar]
  4. Larsson L. I., Rehfeld J. F. Characterization of antral gastrin cells with region-specific antisera. J Histochem Cytochem. 1977 Dec;25(12):1317–1321. doi: 10.1177/25.12.925341. [DOI] [PubMed] [Google Scholar]
  5. Lilja B., Svensson S. E. Gastric secretion during pregnancy and lactation in the rat. J Physiol. 1967 May;190(2):261–272. doi: 10.1113/jphysiol.1967.sp008206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Raptis S., von Berger L., Dollinger H. C., Fazekas A. A., Pfeiffer E. F. Hypergastrinemia induced by glucocorticoid and corticotropin treatment in man. Am J Dig Dis. 1976 May;21(6):376–380. doi: 10.1007/BF01072659. [DOI] [PubMed] [Google Scholar]
  7. Takeuchi K., Okabe S., Takagi K. Influence of pregnancy and lactation on the healing processes of gastric and duodenal ulcer models in rat. Experientia. 1974 Apr 15;30(4):366–368. doi: 10.1007/BF01921667. [DOI] [PubMed] [Google Scholar]
  8. Walsh J. H., Lam S. K. Physiology and pathology of gastrin. Clin Gastroenterol. 1980 Sep;9(3):567–591. [PubMed] [Google Scholar]

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