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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1987 Oct;68(5):637–642.

The influence of irradiation on the biological half-life of prostacyclin in plasma of patients with gastrointestinal cancer.

P Polterauer 1, H Sinzinger 1, B A Peskar 1
PMCID: PMC2013186  PMID: 3318903

Abstract

In seven patients suffering from inoperable pancreatic cancer and in 14 patients with inoperable colonic cancer the half-life (T/2) of prostaglandin (PG)I2 in plasma in vitro has been determined before and at various intervals after irradiation. No significant difference of PGI2-T/2 could be observed either before irradiation, at the end of the irradiation period or 3 and 6 weeks after the last irradiation. Thus irradiation does not appear to interfere with the degradation of PGI2-T/2 in plasma. In patients with inoperable pancreatic and colonic cancer the PGI2-T/2 was not significantly different to that of the PGI2-T/2 of controls. Thus, a shortening of PGI2-T/2 is not a common feature in tumour patients. Hyperaggregation promoting seeding of metastases is not influenced by irradiation via the particular parameter of the PG-system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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