Abstract
The dystrophic retina of the cinnamon mouse homozygous for the gene for microphthalmia (mi/mi) has a population of large ganglion cells. Unilateral enucleation and examination of the dorsal lateral geniculate nucleus using the Fink-Heimer technique showed that, while there was continuing degeneration argyrophilia in the dorsal lateral geniculate nucleus secondary to the retinopathy, there was additional degeneration attributable to enucleation. In addition, the pattern of degeneration indicated that the axon terminals were less mature than those of the cinnamon and heterozygous (mi/+) mice. Quantitative study of the dorsal lateral geniculate nucleus in the homozygous (mi/mi) mouse showed that the nucleus is small with fewer neurons and that the markers for protein metabolism, namely volume of nucleoli and cytoplasmic RNA, are reduced when compared to the cinnamon and heterozygous (mi/+) mice. It is concluded that the portion of the retino-geniculate pathway represented by the large ganglion cells in the retina, develops in the absence of patterned visual stimuli, but is less mature and has a more limited functional activity than controls.
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- Cullen M. J., Kaiserman-Abramof I. R. Cytological organization of the dorsal lateral geniculate nuclei in mutant anophthalmic and postnatally enucleated mice. J Neurocytol. 1976 Aug;5(4):407–424. doi: 10.1007/BF01181648. [DOI] [PubMed] [Google Scholar]
- Fink R. P., Heimer L. Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system. Brain Res. 1967 Apr;4(4):369–374. doi: 10.1016/0006-8993(67)90166-7. [DOI] [PubMed] [Google Scholar]
- Heumann D., Rabinowicz T. Postnatal development of the dorsal lateral geniculate nucleus in the normal and enucleated albino mouse. Exp Brain Res. 1980;38(1):75–85. doi: 10.1007/BF00237933. [DOI] [PubMed] [Google Scholar]
- Hickey T. L., Spear P. D., Kratz K. E. Quantitative studies of cell size in the cat's dorsal lateral geniculate nucleus following visual deprivation. J Comp Neurol. 1977 Mar 15;172(2):265–281. doi: 10.1002/cne.901720206. [DOI] [PubMed] [Google Scholar]
- Hubel D. H., Wiesel T. N. The period of susceptibility to the physiological effects of unilateral eye closure in kittens. J Physiol. 1970 Feb;206(2):419–436. doi: 10.1113/jphysiol.1970.sp009022. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leonard C. M. A method for assessing stages of neural maturation. Brain Res. 1973 Apr 27;53(2):412–416. doi: 10.1016/0006-8993(73)90225-4. [DOI] [PubMed] [Google Scholar]
- Leonard C. M. Developmental changes in olfactory bulb projections revealed by degeneration argyrophilia. J Comp Neurol. 1975 Aug 15;162(4):467–486. doi: 10.1002/cne.901620405. [DOI] [PubMed] [Google Scholar]
- Lund J. S., Lund R. D. The effects of varying periods of visual deprivation on synaptogenesis in the superior colliculus of the rat. Brain Res. 1972 Jul 13;42(1):21–32. doi: 10.1016/0006-8993(72)90039-x. [DOI] [PubMed] [Google Scholar]
- Scholtz C. L., Chan K. K. Complicated colobomatous microphthalmia in the microphthalmic (mi/mi) mouse. Development. 1987 Apr;99(4):501–508. doi: 10.1242/dev.99.4.501. [DOI] [PubMed] [Google Scholar]