Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1968 Jan;52(1):97–110.

Hepatic changes produced by a single dose of endotoxin in the germfree mouse. Histochemistry, light microscopy, fluorescence microscopy, and electron microscopy.

E Levy, B H Ruebner
PMCID: PMC2013317  PMID: 5634511

Full text

PDF
97

Images in this article

107Fig. 1
on p.107
107Fig. 2
on p.107
107Fig. 3
on p.107
108Figs. 4-7
on p.108
109Fig. 8
on p.109
109Fig. 9
on p.109
110Fig. 10
on p.110

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEAVER D. L. Vitamin A deficiency in the germ-free rat. Am J Pathol. 1961 Mar;38:335–357. [PMC free article] [PubMed] [Google Scholar]
  2. Bauer H., Paronetto F., Porro R. F., Einheber A., Popper H. The influence of the microbial flora on liver injury and associated serum gamma-globulin elevation. A study in germ-free rats treated with 3'-methyl-4-dimethylaminoazobenzene. Lab Invest. 1967 Jun;16(6):847–857. [PubMed] [Google Scholar]
  3. Brewer D. B., Heath D. Electron microscopy of anoxic vacuolation in the liver cell and its comparison with sucrose vacuolation. J Pathol Bacteriol. 1965 Oct;90(2):437–441. doi: 10.1002/path.1700900211. [DOI] [PubMed] [Google Scholar]
  4. CASTALDI P. A., FIRKIN B. G., BLACKWELL P. M., CLIFFORD K. I. An electron microscopic study of the changes in platelets during viscous metamorphosis. Blood. 1962 Nov;20:566–580. [PubMed] [Google Scholar]
  5. FINE J., FRANK E. D., RAVIN H. A., RUTENBERG S. H., SCHWEINBURG F. B. The bacterial factor in traumatic shock. N Engl J Med. 1959 Jan 29;260(5):214–220. doi: 10.1056/NEJM195901292600505. [DOI] [PubMed] [Google Scholar]
  6. HOVIG T. The ultrastructure of rabbit blood platelet aggregates. Thromb Diath Haemorrh. 1962 Dec 20;8:455–471. [PubMed] [Google Scholar]
  7. Hokenson E. O., Hansen P. A. Flazo orange for masking of auto and nonspecific fluorescence of leukocytes and tissue cells. Stain Technol. 1966 Jan;41(1):9–14. doi: 10.3109/10520296609116272. [DOI] [PubMed] [Google Scholar]
  8. JENSEN S. B., MERGENHAGEN S. E., FITZGERALD R. J. Susceptibility of conventional and garmfree mice to lethal effects of endotoxin. Proc Soc Exp Biol Med. 1963 Jul;113:710–714. doi: 10.3181/00379727-113-28469. [DOI] [PubMed] [Google Scholar]
  9. LANDY M., SHEAR M. J. Similarity of host responses elicited by polysaccharides of animal and plant origin and by bacterial endotoxins. J Exp Med. 1957 Jul 1;106(1):77–97. doi: 10.1084/jem.106.1.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LANDY M., WHITBY J. L., MICHAEL J. G., WOODS M. W., NEWTON W. L. Effect of bacterial endotoxin in germ-free mice. Proc Soc Exp Biol Med. 1962 Feb;109:352–356. doi: 10.3181/00379727-109-27200. [DOI] [PubMed] [Google Scholar]
  11. LENDRUM A. C., FRASER D. S., SLIDDERS W., HENDERSON R. Studies on the character and staining of fibrin. J Clin Pathol. 1962 Sep;15:401–413. doi: 10.1136/jcp.15.5.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LEVENSON S. M., TENNANT B. Some metabolic and nutritional studies with germfree animals. Fed Proc. 1963 Jan-Feb;22:109–119. [PubMed] [Google Scholar]
  13. Levy E., Ruebner B. H. Hepatic changes produced by a single dose of endotoxin in the mouse. Light microscopy and histochemistry. Am J Pathol. 1967 Aug;51(2):269–285. [PMC free article] [PubMed] [Google Scholar]
  14. MIRAND E. A., GRACE J. T., Jr RESPONSES OF GERM-FREE MICE TO FRIEND VIRUS. Nature. 1963 Oct 5;200:92–93. doi: 10.1038/200092a0. [DOI] [PubMed] [Google Scholar]
  15. RUBENSTEIN H. S., FINE J., COONS A. H. Localization of endotoxin in the walls of the peripheral vascular system during lethal endotoxemia. Proc Soc Exp Biol Med. 1962 Nov;111:458–467. doi: 10.3181/00379727-111-27824. [DOI] [PubMed] [Google Scholar]
  16. SCHAEDLER R. W., DUBOS R. J. The fecal flora of various strains of mice. Its bearing on their susceptibility to endotoxin. J Exp Med. 1962 Jun 1;115:1149–1160. doi: 10.1084/jem.115.6.1149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Trowell O. A. The experimental production of watery vacuolation of the liver. J Physiol. 1946 Dec 6;105(3):268–297. [PMC free article] [PubMed] [Google Scholar]
  18. VASSALLI P., SIMON G., ROUILLER C. ULTRASTRUCTURAL STUDY OF PLATELET CHANGES INITIATED IN VIVO BY THROMBIN. J Ultrastruct Res. 1964 Oct;11:374–387. doi: 10.1016/s0022-5320(64)90040-1. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES