Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1968 Feb;52(2):477–502.

Hepatic changes produced by a single dose of endotoxin in the mouse. Electron microscopy.

E Levy, R J Slusser, B H Ruebner
PMCID: PMC2013341  PMID: 5639556

Full text

PDF
477

Images in this article

491Fig. 1
on p.491
491Fig. 2
on p.491
491Fig. 3
on p.491
493Fig. 4
on p.493
493Fig. 5
on p.493
493Fig. 6
on p.493
495Fig. 7
on p.495
495Fig. 8
on p.495
497Fig. 9
on p.497
497Fig. 10
on p.497
499Fig. 11
on p.499
499Fig. 12
on p.499
501Fig. 13
on p.501
501Fig. 14
on p.501
501Fig. 15
on p.501
502Fig. 16
on p.502
502Fig. 17
on p.502

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASHWORTH C. T., SANDERS E., ARNOLD N. Hepatic lipids; fine structural changes in liver cells after high-fat, high-cholesterol, and choline-deficient diets in rats. Arch Pathol. 1961 Dec;72:625–636. [PubMed] [Google Scholar]
  2. Ashworth C. T., Werner D. J., Glass M. D., Arnold N. J. Spectrum of fine structural changes in hepatocellular injury due to thioacetamide. Am J Pathol. 1965 Dec;47(6):917–951. [PMC free article] [PubMed] [Google Scholar]
  3. BENNETT H. S., LUFT J. H., HAMPTON J. C. Morphological classifications of vertebrate blood capillaries. Am J Physiol. 1959 Feb;196(2):381–390. doi: 10.1152/ajplegacy.1959.196.2.381. [DOI] [PubMed] [Google Scholar]
  4. BLADEN H. A., MERGENHAGEN S. E. ULTRASTRUCTURE OF VEILLONELLA AND MORPHOLOGICAL CORRELATION OF AN OUTER MEMBRANE WITH PARTICLES ASSOCIATED WITH ENDOTOXIC ACTIVITY. J Bacteriol. 1964 Nov;88:1482–1492. doi: 10.1128/jb.88.5.1482-1492.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BREWER D. B., HEATH D. DEVELOPMENT OF SUCROSE VACUOLES FROM LIVER-CELL LYSOSOMES. J Pathol Bacteriol. 1964 Apr;87:405–408. doi: 10.1002/path.1700870220. [DOI] [PubMed] [Google Scholar]
  6. Beer H., Braude A. I., Brinton C. C., Jr A study of particle sizes, shapes and toxicities present in a boivin-type endotoxic preparation. Ann N Y Acad Sci. 1966 Jun 30;133(2):450–475. doi: 10.1111/j.1749-6632.1966.tb52383.x. [DOI] [PubMed] [Google Scholar]
  7. Biava C., Mukhlova-Montiel M. Electron Microscopic Observations on Councilman-Like Acidophilic Bodies and Other Forms of Acidophilic Changes in Human Liver Cells. Am J Pathol. 1965 May;46(5):775–802. [PMC free article] [PubMed] [Google Scholar]
  8. Bruni C., Porter K. R. The Fine Structure of the Parenchymal Cell of the Normal Rat Liver: I. General Observations. Am J Pathol. 1965 May;46(5):691–755. [PMC free article] [PubMed] [Google Scholar]
  9. CASLEY-SMITH J. R. The identification of chylomicra and lipoproteins in tissue sections and their passage into jejunal lacteals. J Cell Biol. 1962 Nov;15:259–277. doi: 10.1083/jcb.15.2.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. COSSEL L. [Electron microscopic studies on the liver sinusoids in viral hepatitis]. Klin Wochenschr. 1959 Dec 15;37:1263–1278. doi: 10.1007/BF01488544. [DOI] [PubMed] [Google Scholar]
  11. Cossel L. Uber akutes Auftreten von Basalmembranen an den Lebersinusoiden. (Beitrag zur Kenntnis der kapillären Basalmembran) Beitr Pathol Anat. 1966 Aug;134(1):103–122. [PubMed] [Google Scholar]
  12. DAEMS W. T. The micro-anatomy of the smallestbiliary pathways in mouse liver tissue. Acta Anat (Basel) 1961;46:1–24. doi: 10.1159/000141765. [DOI] [PubMed] [Google Scholar]
  13. DAVID H. [On the morphology of the liver cell memberane]. Z Zellforsch Mikrosk Anat. 1961;55:220–234. [PubMed] [Google Scholar]
  14. DES PREZ R. M., HOROWITZ H. I., HOOK E. W. Effects of bacterial endotoxin on rabbit platelets. I. Platelet aggregation and release of platelet factors in vitro. J Exp Med. 1961 Dec 1;114:857–874. doi: 10.1084/jem.114.6.857. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. DONIACH I., WEINBREN K. The development of inclusion bodies in the cells of the rat's liver after partial hepatectomy. Br J Exp Pathol. 1952 Oct;33(5):499–505. [PMC free article] [PubMed] [Google Scholar]
  16. DU BOIS A. M. Actions de l'intoxication alloxanique sur le foie de cobaye. Z Zellforsch Mikrosk Anat. 1954 Sep 13;40(6):585–604. [PubMed] [Google Scholar]
  17. David-Ferreira J. F. The blood platelet: electron microscopic studies. Int Rev Cytol. 1964;17:99–148. doi: 10.1016/s0074-7696(08)60406-4. [DOI] [PubMed] [Google Scholar]
  18. Farrar W. E., Jr, Corwin L. M. The essential role of the liver in detoxification of endotoxin. Ann N Y Acad Sci. 1966 Jun 30;133(2):668–684. doi: 10.1111/j.1749-6632.1966.tb52397.x. [DOI] [PubMed] [Google Scholar]
  19. GILBERT R. P. Mechanisms of the hemodynamic effects of endotoxin. Physiol Rev. 1960 Apr;40:245–279. doi: 10.1152/physrev.1960.40.2.245. [DOI] [PubMed] [Google Scholar]
  20. Glinsmann W. H., Ericsson J. L. Observations on the subcellular organization of hepatic parenchymal cells. II. Evolution of reversible alterations induced by hypoxia. Lab Invest. 1966 Apr;15(4):762–777. [PubMed] [Google Scholar]
  21. Guth P. S., Amaro J., Sellinger O. Z., Elmer L. Studies in vitro and in vivo of the effects of chlorpromazine on rat liver lysosomes. Biochem Pharmacol. 1965 May;14(5):769–775. doi: 10.1016/0006-2952(65)90095-x. [DOI] [PubMed] [Google Scholar]
  22. HAMPTON J. C. Are-evaluation of the submicroscopic structure of liver. Tex Rep Biol Med. 1960;18:602–611. [PubMed] [Google Scholar]
  23. HAYES T. L., HEWITT J. E. Visualization of individual lipoprotein macromolecules in the electron microscope. J Appl Physiol. 1957 Nov;11(3):425–428. doi: 10.1152/jappl.1957.11.3.425. [DOI] [PubMed] [Google Scholar]
  24. HILL R. B., Jr, DROKE W. E., HAYS A. P. HEPATIC LIPID METABOLISM IN THE CORTISONE-TREATED RAT. Exp Mol Pathol. 1965 Jun;11:320–327. doi: 10.1016/0014-4800(65)90007-9. [DOI] [PubMed] [Google Scholar]
  25. HOLLE G. [On the electron microscopic findings in the liver in viral hepatitis and the problem of hepatocellular icterus]. Dtsch Med Wochenschr. 1960 Nov 25;85:2089–2093. doi: 10.1055/s-0028-1112702. [DOI] [PubMed] [Google Scholar]
  26. Hamilton R. L., Regen D. M., Gray M. E., LeQuire V. S. Lipid transport in liver. I. Electron microscopic identification of very low density lipoproteins in perfused rat liver. Lab Invest. 1967 Feb;16(2):305–319. [PubMed] [Google Scholar]
  27. Jones A. L., Ruderman N. B., Herrera M. G. An electron microscopic study of lipoprotein production and release by the isolated perfused rat liver. Proc Soc Exp Biol Med. 1966 Oct;123(1):4–9. doi: 10.3181/00379727-123-31388. [DOI] [PubMed] [Google Scholar]
  28. KUFF E. L., DALTON A. J. Identification of molecular ferritin in homogenates and sections of rat liver. J Ultrastruct Res. 1957 Nov;1(1):62–73. doi: 10.1016/s0022-5320(57)80013-6. [DOI] [PubMed] [Google Scholar]
  29. Klion F. M., Schaffner F. The ultrastructure of acidophilic "Councilman-like" bodies in the liver. Am J Pathol. 1966 May;48(5):755–767. [PMC free article] [PubMed] [Google Scholar]
  30. Levy E., Ruebner B. H. Hepatic changes produced by a single dose of endotoxin in the mouse. Light microscopy and histochemistry. Am J Pathol. 1967 Aug;51(2):269–285. [PMC free article] [PubMed] [Google Scholar]
  31. MATSUZAWA T., WILSON R. OXYGEN CHANGES IN TISSUES OF GERMFREE AND CONVENTIONAL MICE AFTER INOCULATION OF BACTERIAL ENDOTOXIN. Tohoku J Exp Med. 1965 May 25;85:361–364. doi: 10.1620/tjem.85.361. [DOI] [PubMed] [Google Scholar]
  32. McKay D. G., Margaretten W., Csavossy I. An electron microscope study of the effects of bacterial endotoxin on the blood-vascular system. Lab Invest. 1966 Dec;15(12):1815–1829. [PubMed] [Google Scholar]
  33. NAIRN R. C., CHADWICK C. S., McENTEGART M. G. Fluorescent protein tracers in the study of experimental liver damage. J Pathol Bacteriol. 1958 Jul;76(1):143–153. doi: 10.1002/path.1700760115. [DOI] [PubMed] [Google Scholar]
  34. OUDEA P. R. Anoxic changes of liver cells. Electron microscopic study after injection of colloidal mercury. Lab Invest. 1963 Mar;12:386–394. [PubMed] [Google Scholar]
  35. PROSE P. H., LEE L., BALK S. D. ELECTRON MICROSCOPIC STUDY OF THE PHAGOCYTIC FIBRIN-CLEARING MECHANISM. Am J Pathol. 1965 Sep;47:403–417. [PMC free article] [PubMed] [Google Scholar]
  36. REYNOLDS E. S. LIVER PARENCHYMAL CELL INJURY. I. INITIAL ALTERATIONS OF THE CELL FOLLOWING POISONING WITH CARBON TETRACHLORIDE. J Cell Biol. 1963 Oct;19:139–157. doi: 10.1083/jcb.19.1.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. RODMAN N. F., Jr, MASON R. G., McDEVITT N. B., BRINKHOUS K. M. Morphologic alterations of human blood platelets during early phases of clotting. Electron microscopic observations of thin sections. Am J Pathol. 1962 Mar;40:271–284. [PMC free article] [PubMed] [Google Scholar]
  38. Ruebner B. H., Hirano T., Slusser R. J. Electron microscopy of the hepatocellular and Kupffer-cell lesions of mouse hepatitis, with particular reference to the effect of cortisone. Am J Pathol. 1967 Aug;51(2):163–189. [PMC free article] [PubMed] [Google Scholar]
  39. SCHMIDT F. C. [Electron microscopic studies on the sinusoid parietal cell (Kupffer's cells) in white mice]. Anat Anz. 1960 Dec 27;108:376–387. [PubMed] [Google Scholar]
  40. STEINER J. W., PHILLIPS M. J., BAGLIO C. M. ELECTRON MICROSCOPY IN THE EXCRETORY PATHWAYS IN THE LIVER IN ALPHA-NAPHTHYL ISOTHIOCYANATE INTOXICATION. A STUDY OF INTRAHEPATIC CHOLESTASIS. Am J Pathol. 1963 Oct;43:677–696. [PMC free article] [PubMed] [Google Scholar]
  41. STILL W. J., BOULT E. H. Electron microscopic appearance of fibrin in thin sections. Nature. 1957 Apr 27;179(4565):868–869. doi: 10.1038/179868b0. [DOI] [PubMed] [Google Scholar]
  42. Stehbens W. E., Biscoe T. J. The ultrastructure of early platelet aggregation in vivo. Am J Pathol. 1967 Feb;50(2):219–243. [PMC free article] [PubMed] [Google Scholar]
  43. Stein O., Stein Y. Lipid synthesis, intracellular transport, storage, and secretion. I. Electron microscopic radioautographic study of liver after injection of tritiated palmitate or glycerol in fasted and ethanol-treated rats. J Cell Biol. 1967 May;33(2):319–339. doi: 10.1083/jcb.33.2.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. TROTTER N. L. A FINE STRUCTURE STUDY OF LIPID IN MOUSE LIVER REGENERATING AFTER PARTIAL HEPATECTOMY. J Cell Biol. 1964 May;21:233–244. doi: 10.1083/jcb.21.2.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. TRUMP B. F., GOLDBLATT P. J., STOWELL R. E. STUDIES ON NECROSIS OF MOUSE LIVER IN VITRO. ULTRASTRUCTURAL ALTERATIONS IN THE MITOCHONDRIA OF HEPATIC PARENCHYMAL CELLS. Lab Invest. 1965 Apr;14:343–371. [PubMed] [Google Scholar]
  46. Trowell O. A. The experimental production of watery vacuolation of the liver. J Physiol. 1946 Dec 6;105(3):268–297. [PMC free article] [PubMed] [Google Scholar]
  47. Trump B. F., Goldblatt P. J., Stowell R. E. Studies of mouse liver necrosis in vitro. Ultrastructural and cytochemical alterations in hepatic parenchymal cell nuclei. Lab Invest. 1965 Nov;14(11):1969–1999. [PubMed] [Google Scholar]
  48. Trump B. F., Goldblatt P. J., Stowell R. E. Studies of necrosis in vitro of mouse hepatic parenchymal cells. Ultrastructural alterations in endoplasmic reticulum, Golgi apparatus, plasma membrane, and lipid droplets. Lab Invest. 1965 Nov;14(11):2000–2028. [PubMed] [Google Scholar]
  49. Trump B. F., Goldblatt P. J., Stowell R. E. Studies of necrosis in vitro of mouse hepatic parenchymal cells. Ultrastructural and cytochemical alterations of cytosomes, cytosegresomes, multivesicular bodies, and microbodies and their relation to the lysosome concept. Lab Invest. 1965 Nov;14(11):1946–1968. [PubMed] [Google Scholar]
  50. VASSALLI P., SIMON G., ROUILLER C. ULTRASTRUCTURAL STUDY OF PLATELET CHANGES INITIATED IN VIVO BY THROMBIN. J Ultrastruct Res. 1964 Oct;11:374–387. doi: 10.1016/s0022-5320(64)90040-1. [DOI] [PubMed] [Google Scholar]
  51. VENABLE J. H., COGGESHALL R. A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY. J Cell Biol. 1965 May;25:407–408. doi: 10.1083/jcb.25.2.407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. WASSERMANN F. The structure of the wall of the hepatic sinusoids in the electron microscope. Z Zellforsch Mikrosk Anat. 1958;49(1):13–32. doi: 10.1007/BF00335060. [DOI] [PubMed] [Google Scholar]
  53. White J. G., Krivit W. The ultrastructural localization and release of platelet lipids. Blood. 1966 Feb;27(2):167–186. [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES