Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1968 May;52(5):1067–1079.

Vitamin E deficiency. A sequential light and electron microscopic study of skeletal muscle degeneration in weanling rabbits.

J F Van Vleet, B V Hall, J Simon
PMCID: PMC2013345  PMID: 5646510

Full text

PDF
1067

Images in this article

1077Fig. 1
on p.1077
1077Fig. 2
on p.1077
1078Fig. 3
on p.1078
1078Fig. 4
on p.1078
1079Fig. 5
on p.1079
1079Figs. 6-7
on p.1079

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEAUFAY H., VAN CAMPENHOUT E., DE DUVE C. Tissue fractionation studies. II. Influence of various hepatotoxic treatments on the state of some bound enzymes in rat liver. Biochem J. 1959 Dec;73:617–623. doi: 10.1042/bj0730617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BRINK F. The role of calcium ions in neural processes. Pharmacol Rev. 1954 Sep;6(3):243–298. [PubMed] [Google Scholar]
  3. CHIFFELLE T. L., PUTT F. A. Propylene and ethylene glycol as solvents for Sudan IV and Sudan black B. Stain Technol. 1951 Jan;26(1):51–56. doi: 10.3109/10520295109113178. [DOI] [PubMed] [Google Scholar]
  4. Cheville N. F. The pathology of vitamin E deficiency in the chick. Pathol Vet. 1966;3(3):208–225. doi: 10.1177/030098586600300305. [DOI] [PubMed] [Google Scholar]
  5. DAM H., PRANGE I., SØNDERGAARD E. Muscular degeneration (white striation of muscles) in chicks reared on vitamin E deficient, low fat diets. Acta Pathol Microbiol Scand. 1952;31(2):172–184. doi: 10.1111/j.1699-0463.1952.tb04852.x. [DOI] [PubMed] [Google Scholar]
  6. DESAI I. D., CALVERT C. C., SCOTT M. L., TAPPEL A. L. PEROXIDATION AND LYSOSOMES IN NUTRITIONAL MUSCULAR DYSTROPHY OF CHICKS. Proc Soc Exp Biol Med. 1964 Feb;115:462–466. doi: 10.3181/00379727-115-28942. [DOI] [PubMed] [Google Scholar]
  7. DONALDSON K. O., NASON A., GARRETT R. H. The role of lipides in electron transport. IV. Tocopherol as a specific cofactor of mammalian cytochrome c reductase. J Biol Chem. 1958 Sep;233(3):572–579. [PubMed] [Google Scholar]
  8. DRAPER H. H., BERGAN J. G., CHIU M., CSALLANY A. S., BOARO A. V. A FURTHER STUDY OF THE SPECIFICITY OF THE VITAMIN E REQUIREMENT FOR REPRODUCTION. J Nutr. 1964 Dec;84:395–400. doi: 10.1093/jn/84.4.395. [DOI] [PubMed] [Google Scholar]
  9. Detwiler T. C., Garrett R. H., Nason A. Effects of digitonin and tocopherol on bovine heart muscle reduced diphosphopyridine nucleotide- and succinate-cytochrome c reductase and cytochrome c oxidase. J Biol Chem. 1966 Apr 10;241(7):1621–1631. [PubMed] [Google Scholar]
  10. FORBES R. M., DRAPER H. H. Production and study of vitamin E deficiency in the baby pig. J Nutr. 1958 Aug 10;65(4):535–545. doi: 10.1093/jn/65.4.535. [DOI] [PubMed] [Google Scholar]
  11. GREEN J., DIPLOCK A. T., BUNYAN J., EDWIN E. E., McHALE D. Ubiquinone (coenzyme Q) and the function of vitamin E. Nature. 1961 Apr 22;190:318–325. doi: 10.1038/190318a0. [DOI] [PubMed] [Google Scholar]
  12. Gauthier G. F., Padykula H. A. Cytological studies of fiber types in skeletal muscle. A comparative study of the mammalian diaphragm. J Cell Biol. 1966 Feb;28(2):333–354. doi: 10.1083/jcb.28.2.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. LEE D. J., CHIU M., DRAPER H. H. EFFECT OF VITAMIN E DEFICIENCY ON UBIQUINONE LEVELS IN RAT AND RABBIT LIVER. Nature. 1965 Jan 16;205:288–290. doi: 10.1038/205288a0. [DOI] [PubMed] [Google Scholar]
  14. LEHMAN I. R., NASON A. The role of lipides in electron transport. II. Lipide cofactor replaceable by tocopherol for the enzymatic reduction of cytochrome c. J Biol Chem. 1956 Sep;222(1):511–530. [PubMed] [Google Scholar]
  15. LUFT J. H. Improvements in epoxy resin embedding methods. J Biophys Biochem Cytol. 1961 Feb;9:409–414. doi: 10.1083/jcb.9.2.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. MASON K. E., HARTSOUGH G. R. "Steatiti or "yellow fat" in mink, and its relation to dietary fats and inadequacy of vitamin E. J Am Vet Med Assoc. 1951 Jul;119(892):72–75. [PubMed] [Google Scholar]
  17. Nason A., Garrett R. H., Nair P. P., Vasington F. D., Detwiler T. C. Inhibition by digitonin of bovine heart muscle DPNH-cytochrome c reductase and its specific reversal by the tocopherols. Biochem Biophys Res Commun. 1964;14:220–226. doi: 10.1016/0006-291x(64)90439-5. [DOI] [PubMed] [Google Scholar]
  18. PEACHEY L. D. ELECTRON MICROSCOPIC OBSERVATIONS ON THE ACCUMULATION OF DIVALENT CATIONS IN INTRAMITOCHONDRIAL GRANULES. J Cell Biol. 1964 Jan;20:95–111. doi: 10.1083/jcb.20.1.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Pappenheimer A. M. The pathology of nutritional muscular dystrophy in young rats. Am J Pathol. 1939 Mar;15(2):179–184.3. [PMC free article] [PubMed] [Google Scholar]
  20. REYNOLDS E. S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963 Apr;17:208–212. doi: 10.1083/jcb.17.1.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. SABATINI D. D., BENSCH K., BARRNETT R. J. Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. J Cell Biol. 1963 Apr;17:19–58. doi: 10.1083/jcb.17.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. SCARPELLI D. G. EXPERIMENTAL NEPHROCALCINOSIS. A BIOCHEMICAL AND MORPHOLOGIC STUDY. Lab Invest. 1965 Feb;14:123–141. [PubMed] [Google Scholar]
  23. STEMPAK J. G., WARD R. T. AN IMPROVED STAINING METHOD FOR ELECTRON MICROSCOPY. J Cell Biol. 1964 Sep;22:697–701. doi: 10.1083/jcb.22.3.697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. SVOBODA D. J., HIGGINSON J. ULTRASTRUCTURAL HEPATIC CHANGES IN RATS ON A NECROGENIC DIET. Am J Pathol. 1963 Sep;43:477–495. [PMC free article] [PubMed] [Google Scholar]
  25. TAPPEL A. L. Studies of the mechanism of vitamin E action. III. In vitro copolymerization of oxidized fats with protein. Arch Biochem Biophys. 1955 Feb;54(2):266–280. doi: 10.1016/0003-9861(55)90039-4. [DOI] [PubMed] [Google Scholar]
  26. Van Vleet J. F., Hall B. V., Simon J. Vitamin E deficiency: a sequential study by means of light and electron microscopy of the alterations occurring in regeneration of skeletal muscle of affected weanling rabbits. Am J Pathol. 1967 Nov;51(5):815–830. [PMC free article] [PubMed] [Google Scholar]
  27. WEINSTOCK I. M., GOLDRICH A. D., MILHORAT A. T. Enzyme studies in muscular dystrophy. I. Muscle proteolytic activity and vitamin E-deficiency. Proc Soc Exp Biol Med. 1955 Feb;88(2):257–260. doi: 10.3181/00379727-88-21556. [DOI] [PubMed] [Google Scholar]
  28. WEINSTOCK I. M., LUKACS M. ENZYME STUDIES IN MUSCULAR DYSTROPHY. V. VITAMIN E-DEFICIENCY AND DENERVATION ATROPHY. Enzymol Biol Clin (Basel) 1965;19:89–102. [PubMed] [Google Scholar]
  29. ZALKIN H., TAPPEL A. L., CALDWELL K. A., SHIBKO S., DESAI I. D., HOLLIDAY T. A. Increased lysosomal enzymes in muscular dystrophy of vitamin E-deficient rabbits. J Biol Chem. 1962 Aug;237:2678–2682. [PubMed] [Google Scholar]
  30. ZALKIN H., TAPPEL A. L. Studies of the mechanism of vitamin E action. IV. Lipide peroxidation in the vitamin E-deficient rabbit. Arch Biochem Biophys. 1960 May;88:113–117. doi: 10.1016/0003-9861(60)90205-8. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES