Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1969 Nov;57(2):253–271.

Some alterations in hepatic cytosome structure and acid phosphatase activity induced by DL-ethionine.

P J Goldblatt, G M Williams
PMCID: PMC2013631  PMID: 5360267

Full text

PDF
253

Images in this article

267Fig 1
on p.267
269Fig 2
on p.269
271Fig 3
on p.271
271Fig 4
on p.271
271Fig 5
on p.271

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASHFORD T. P., PORTER K. R. Cytoplasmic components in hepatic cell lysosomes. J Cell Biol. 1962 Jan;12:198–202. doi: 10.1083/jcb.12.1.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arstila A. U., Trump B. F. Studies on cellular autophagocytosis. The formation of autophagic vacuoles in the liver after glucagon administration. Am J Pathol. 1968 Nov;53(5):687–733. [PMC free article] [PubMed] [Google Scholar]
  3. BAGLIO C. M., FARBER E. CORRESPONDENCE BETWEEN RIBOSOME AGGREGATION PATTERNS IN RAT LIVER HOMOGENATES AND IN ELECTRON MICROGRAPHS FOLLOWING ADMINISTRATION OF ETHIONINE. J Mol Biol. 1965 Jun;12:466–467. doi: 10.1016/s0022-2836(65)80269-8. [DOI] [PubMed] [Google Scholar]
  4. BEAUFAY H., VAN CAMPENHOUT E., DE DUVE C. Tissue fractionation studies. II. Influence of various hepatotoxic treatments on the state of some bound enzymes in rat liver. Biochem J. 1959 Dec;73:617–623. doi: 10.1042/bj0730617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BENNETT H. S., LUFT J. H. zeta-Collidine as a basis for buffering fixatives. J Biophys Biochem Cytol. 1959 Aug;6(1):113–114. doi: 10.1083/jcb.6.1.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BERTHET J., DE DUVE C. Tissue fractionation studies. I. The existence of a mitochondria-linked, enzymically inactive form of acid phosphatase in rat-liver tissue. Biochem J. 1951 Dec;50(2):174–181. doi: 10.1042/bj0500174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Baglio C. M., Farber E. Reversal by adenine of the ethionine-induced lipid accumulation in the endoplasmic reticulum of the rat liver. A preliminary report. J Cell Biol. 1965 Dec;27(3):591–601. doi: 10.1083/jcb.27.3.591. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bruni C., Porter K. R. The Fine Structure of the Parenchymal Cell of the Normal Rat Liver: I. General Observations. Am J Pathol. 1965 May;46(5):691–755. [PMC free article] [PubMed] [Google Scholar]
  9. DE DUVE C., PRESSMAN B. C., GIANETTO R., WATTIAUX R., APPELMANS F. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem J. 1955 Aug;60(4):604–617. doi: 10.1042/bj0600604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. De Duve C., Wattiaux R. Functions of lysosomes. Annu Rev Physiol. 1966;28:435–492. doi: 10.1146/annurev.ph.28.030166.002251. [DOI] [PubMed] [Google Scholar]
  11. ERICSSON J. L., TRUMP B. F. ELECTRON MICROSCOPIC STUDIES OF THE EPITHELIUM OF THE PROXIMAL TUBULE OF THE RAT KIDNEY. I. THE INTRACELLULAR LOCALIZATION OF ACID PHOSPHATASE. Lab Invest. 1964 Nov;13:1427–1456. [PubMed] [Google Scholar]
  12. ERICSSON J. L., TRUMP B. F., WEIBEL J. ELECTRON MICROSCOPIC STUDIES OF THE PROXIMAL TUBULE OF THE RAT KIDNEY. II. CYTOSEGRESOMES AND CYTOSOMES: THEIR RELATIONSHIP TO EACH OTHER AND TO THE LYSOSOME CONCEPT. Lab Invest. 1965 Jul;14:1341–1365. [PubMed] [Google Scholar]
  13. FARBER E., SHULL K. H., VILLA-TREVINO S., LOMBARDI B., THOMAS M. BIOCHEMICAL PATHOLOGY OF ACUTE HEPATIC ADENOSINETRIPHOSPHATE DEFICIENCY. Nature. 1964 Jul 4;203:34–40. doi: 10.1038/203034a0. [DOI] [PubMed] [Google Scholar]
  14. Farber E. Ethionine fatty liver. Adv Lipid Res. 1967;5:119–183. [PubMed] [Google Scholar]
  15. GIANETTO R., DE DUVE C. Tissue fractionation studies. 4. Comparative study of the binding of acid phosphatase, beta-glucuronidase and cathepsin by rat-liver particles. Biochem J. 1955 Mar;59(3):433–438. doi: 10.1042/bj0590433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. GRIFFIN C. C., WARAVDEKAR V. S., GOLDBLATT P. J., TRUMP B. F., STOWELL R. E. EFFECTS OF FREEZING AND THAWING ON ENZYMES OF MOUSE LIVER: ACID PHOSPHATASE, GLUCOSE-6-PHOSPHATE, URICASE, AND ADENOSINE DEAMINASE. Arch Pathol. 1965 Jun;79:595–599. [PubMed] [Google Scholar]
  17. Griffin C. C., Waravdekar V. S., Trump B. F., Goldblatt P. J., Stowell R. E. Studies on necrosis of mouse liver in vitro. Alterations in activities of succinoxidase, succinic dehydrogenase, glutamic dehydrogenase, acid phosphatase, uricase, glucose-6-phosphatase and NAD-pyrophosphorylase. Am J Pathol. 1965 Nov;47(5):833–850. [PMC free article] [PubMed] [Google Scholar]
  18. HRUBAN Z., SPARGO B., SWIFT H., WISSLER R. W., KLEINFELD R. G. Focal cytoplasmic degradation. Am J Pathol. 1963 Jun;42:657–683. [PMC free article] [PubMed] [Google Scholar]
  19. Judah J. D., Ahmed K., McLean A. E., Christie G. S. Ion transport in ethionine intoxication. Lab Invest. 1966 Jan;15(1 Pt 1):167–175. [PubMed] [Google Scholar]
  20. KARNOVSKY M. J. Simple methods for "staining with lead" at high pH in electron microscopy. J Biophys Biochem Cytol. 1961 Dec;11:729–732. doi: 10.1083/jcb.11.3.729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. LUFT J. H. Improvements in epoxy resin embedding methods. J Biophys Biochem Cytol. 1961 Feb;9:409–414. doi: 10.1083/jcb.9.2.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Miyai K., Steiner J. W. Fine structure of interphase liver cell nuclei in acute ethionine intoxication. Lab Invest. 1967 May;16(5):677–692. [PubMed] [Google Scholar]
  23. Miyai K., Steiner J. W. Fine structure of interphase liver cell nuclei in subacute ethionine intoxication. Exp Mol Pathol. 1965 Oct;4(5):525–566. doi: 10.1016/0014-4800(65)90016-x. [DOI] [PubMed] [Google Scholar]
  24. Mäenpä P. H., Raivio K. O., Kekomäki M. P. Liver adenine nucleotides: fructose-induced depletion and its effect on protein synthesis. Science. 1968 Sep 20;161(3847):1253–1254. doi: 10.1126/science.161.3847.1253. [DOI] [PubMed] [Google Scholar]
  25. Okazaki K., Shull K. H., Farber E. Effects of ethionine on adenosine triphosphate levels and ionic composition of liver cell nuclei. J Biol Chem. 1968 Sep 25;243(18):4661–4666. [PubMed] [Google Scholar]
  26. REYNOLDS E. S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963 Apr;17:208–212. doi: 10.1083/jcb.17.1.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. SHULL K. H. Hepatic phosphorylase and adenosine triphosphate levels in ethionine-treated rats. J Biol Chem. 1962 May;237:1734–1735. [PubMed] [Google Scholar]
  28. STEKOL J. A. BIOCHEMICAL BASIS FOR ETHIONINE EFFECTS ON TISSUES. Adv Enzymol Relat Areas Mol Biol. 1963;25:369–393. doi: 10.1002/9780470122709.ch7. [DOI] [PubMed] [Google Scholar]
  29. Shull K. H., McConomy J., Vogt M., Castillo A., Farber E. On the mechanism of induction of hepatic adenosine triphosphate deficiency by ethionine. J Biol Chem. 1966 Nov 10;241(21):5060–5070. [PubMed] [Google Scholar]
  30. TRUMP B. F., ERICSSON J. L. ELECTRON MICROSCOPIC OBSERVATIONS ON THE LOCALIZATION OF ACID PHOSPHATASE IN MOUSE HEPATIC PARENCHYMAL CELLS. Exp Cell Res. 1964 Feb;33:598–601. doi: 10.1016/0014-4827(64)90030-8. [DOI] [PubMed] [Google Scholar]
  31. Trump B. F., Goldblatt P. J., Stowell R. E. Studies of necrosis in vitro of mouse hepatic parenchymal cells. Ultrastructural and cytochemical alterations of cytosomes, cytosegresomes, multivesicular bodies, and microbodies and their relation to the lysosome concept. Lab Invest. 1965 Nov;14(11):1946–1968. [PubMed] [Google Scholar]
  32. VILLA-TREVINO S., SHULL K. H., FARBER E. The role of adenosine triphosphate deficiency in ethionine-induced inhibition of protein synthesis. J Biol Chem. 1963 May;238:1757–1763. [PubMed] [Google Scholar]
  33. Verbin R. S., Goldblatt P. J., Farber E. The biochemical pathology of inhibition of protein synthesis in vivo. The effects of cycloheximide on hepatic parenchymal cell ultrastructure. Lab Invest. 1969 Jun;20(6):529–536. [PubMed] [Google Scholar]
  34. Villa-Trevino S., Shull K. H., Farber E. The inhibition of liver ribonucleic acid synthesis by ethionine. J Biol Chem. 1966 Oct 25;241(20):4670–4674. [PubMed] [Google Scholar]
  35. WATSON M. L. Staining of tissue sections for electron microscopy with heavy metals. J Biophys Biochem Cytol. 1958 Jul 25;4(4):475–478. doi: 10.1083/jcb.4.4.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. WATTIAUX R., WATTIAUX-DECONINCK S., RUTGEERTS M. J., TULKENS P. INFLUENCE OF THE INJECTION OF A SUCROSE SOLUTION ON THE PROPERTIES OF RAT-LIVER LYSOSOMES. Nature. 1964 Aug 15;203:757–758. doi: 10.1038/203757a0. [DOI] [PubMed] [Google Scholar]
  37. Witschi H. P., Aldridge W. N. Uptake, distribution and binding of beryllium to organelles of the rat liver cell. Biochem J. 1968 Feb;106(4):811–820. doi: 10.1042/bj1060811. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES