Spontaneous amyloidosis in LLC mice.

Abstract

Practically all low leukocyte count (LLC) mice over 1 year of age develop renal amyloidosis. Renal amyloid is deposited in the glomeruli and in the interstitium between the convoluted as well as collecting tubules, with consequent development of cysts and necrosis. LLC mice die of chronic renal failure. Electron microscopic studies reveal amyloid fibrils in the mesangium, a thickening of the basement membranes, and fusion of the foot processes in the glomeruli. Massive amounts of amyloid fibrils are also present in the interstitium, where intracellular fibrils in the fibroblasts as well as in the tubular epithelium cells are found. Vesicles, which are probably formed from membrane disruption, and amorphous materials are seen along the basement membranes. LLC mouse amyloidosis is discussed with regard to its potential as a model for studies on amyloidosis as well as the etiology and origin of amyloid fibrils.

Full text

PDF

• 381
• 382
• 383
• 384
• 385
• …
• 398
• Next

Images in this article

Figure 1
on p.387

Figures 2A-2B
on p.387

Figure 5C
on p.396

Figure 4A
on p.392

Figure 4B
on p.393

Figure 5D
on p.397

Figures 2C-2F
on p.389

Figure 5A
on p.394

Figures 3A-3B
on p.390

Figures 3C-3D
on p.391

Figure 5B
on p.395