Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1978 May;91(2):345–354.

Lymphocyte migratory pathways in adjuvant disease. I. Distribution of 51Cr-labeled thoracic duct lymph-borne.

R H Kelly, V S Harvey
PMCID: PMC2018204  PMID: 645829

Abstract

Evidence for selective extravasation of thoracic duct lymph-borne cells, derived from rats with adjuvant disease, within joints of normal or adjuvant arthritic recipients was sough by adoptive transfer of radiolabeled cells. Control studies were carried out in parallel using thoracic ducts cells from normal donors. No increased homing of lymph-borne cells to inflamed portions of the limbs was detected when cells from adjuvant arthritic donors were compared with those of normal controls. Inflammatory changes, ie, adjuvant-induced disease, in the recipient produced a significant nonspecific enhancement of extravasation; cells from normal and adjuvant arthritic donors responded equally well. One difference in migratory behavior between lymph-borne cells from adjuvant arthritic and normal animals was the increased ability of the former to localize within certain lymph nodes. A possible association between this traffic and the development of chronic inflammatory processes within joints is discussed.

Full text

PDF
345

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asherson G. L., Allwood G. G. Inflammatory lymphoid cells. Cells in immunized lymph nodes that move to sites of inflammation. Immunology. 1972 Mar;22(3):493–502. [PMC free article] [PubMed] [Google Scholar]
  2. Bacon P. A., Sewell R. L., Crowther D. Reactive lymphoid cells ('Immunoblasts') in autoimmune and haematological disorders. Clin Exp Immunol. 1975 Feb;19(2):201–208. [PMC free article] [PubMed] [Google Scholar]
  3. Cohen S., McCluskey R. T., Benacerraf B. Studies on the specificity of the cellular infiltrate of delayed hypersensitivity reactions. J Immunol. 1967 Feb;98(2):269–273. [PubMed] [Google Scholar]
  4. DUMONT A. E., MAYER D. J., MULHOLLAND J. H. THE SUPPRESSION OF IMMUNOLOGIC ACTIVITY BY DIVERSION OF THORACIC DUCT LYMPH. Ann Surg. 1964 Sep;160:373–383. doi: 10.1097/00000658-196409000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dorfman R. F., Warnke R. Lymphadenopathy simulating the malignant lymphomas. Hum Pathol. 1974 Sep;5(5):519–550. doi: 10.1016/s0046-8177(74)80005-5. [DOI] [PubMed] [Google Scholar]
  6. Durkin H. G., Thorbecke G. J. Homing of B-lymphocytes to follicles: specific retention of immunologically committed cells. Adv Exp Med Biol. 1973;29(0):63–70. doi: 10.1007/978-1-4615-9017-0_10. [DOI] [PubMed] [Google Scholar]
  7. Ford W. L., Simmonds S. J. The tempo of lymphocyte recirculation from blood to lymph in the rat. Cell Tissue Kinet. 1972 Mar;5(2):175–189. doi: 10.1111/j.1365-2184.1972.tb01014.x. [DOI] [PubMed] [Google Scholar]
  8. Ford W. L. The recruitment of recirculating lymphocytes in the antigenically stimulated spleen. Specific and non-specific consequences of initiating a secondary antibody response. Clin Exp Immunol. 1972 Oct;12(2):243–254. [PMC free article] [PubMed] [Google Scholar]
  9. Freitas A. A., de Sousa M. Control mechanism of lymphocyte traffic. Altered migration of 51Cr-labeled mouse lymph node cells pretreated in vitro with phospholipases. Eur J Immunol. 1976 Oct;6(10):703–711. doi: 10.1002/eji.1830061009. [DOI] [PubMed] [Google Scholar]
  10. Griscelli C., Vassalli P., McCluskey R. T. The distribution of large dividing lymph node cells in syngeneic recipient rats after intravenous injection. J Exp Med. 1969 Dec 1;130(6):1427–1451. doi: 10.1084/jem.130.6.1427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ha T. Y., Waksman B. H. Role of the thymus in tolerance. X. "Suppressor" activity of antigen-stimulated rat thymocytes transferred to normal recipients. J Immunol. 1973 May;110(5):1290–1299. [PubMed] [Google Scholar]
  12. Hall J. G., Morris B., Moreno G. D., Bessis M. C. The ultrastructure and function of the cells in lymph following antigenic stimulation. J Exp Med. 1967 Jan 1;125(1):91–110. doi: 10.1084/jem.125.1.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hall J. G., Parry D. M., Smith M. E. The distribution and differentiation of lymph-borne immunoblasts after intravenous injection into syngeneic recipients. Cell Tissue Kinet. 1972 May;5(3):269–281. doi: 10.1111/j.1365-2184.1972.tb00365.x. [DOI] [PubMed] [Google Scholar]
  14. Halstead T. E., Hall J. G. The homing of lymph-borne immunoblasts to the small gut of neonatal rats. Transplantation. 1972 Sep;14(3):339–346. doi: 10.1097/00007890-197209000-00009. [DOI] [PubMed] [Google Scholar]
  15. Hay J. B., Murphy M. J., Morris B., Bessis M. C. Quantitative studies on the proliferation and differentiation of antibody-forming cells in lymph. Am J Pathol. 1972 Jan;66(1):1–24. [PMC free article] [PubMed] [Google Scholar]
  16. Howard J. C., Hunt S. V., Gowans J. L. Identification of marrow-derived and thymus-derived small lymphocytes in the lymphoid tissue and thoracic duct lymph of normal rats. J Exp Med. 1972 Feb 1;135(2):200–219. doi: 10.1084/jem.135.2.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kelly R. H. Functional anatomy of lymph nodes. I. The paracortical cords. Int Arch Allergy Appl Immunol. 1975;48(6):836–849. doi: 10.1159/000231371. [DOI] [PubMed] [Google Scholar]
  18. Marchalonis J. J., Cone R. E., Santer V. Enzymic iodination. A probe for accessible surface proteins of normal and neoplastic lymphocytes. Biochem J. 1971 Oct;124(5):921–927. doi: 10.1042/bj1240921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. McConnell I., Lachmann P. J., Hobart M. J. Restoration of specific immunological virginity. Nature. 1974 Jul 12;250(462):113–116. doi: 10.1038/250113a0. [DOI] [PubMed] [Google Scholar]
  20. Moore A. R., Hall J. G. Nonspecific entry of thoracic duct immunoblasts into intradermal foci of antigens. Cell Immunol. 1973 Jul;8(1):112–119. doi: 10.1016/0008-8749(73)90098-1. [DOI] [PubMed] [Google Scholar]
  21. Moorhead J. W., Claman H. N. Thymus-derived lymphocytes and hydrocortisone: identification of subsets of theta-bearing cells and redistribution to bone marrow. Cell Immunol. 1972 Sep;5(1):74–86. doi: 10.1016/0008-8749(72)90085-8. [DOI] [PubMed] [Google Scholar]
  22. Morse S. I., Riester S. K. Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. II. The effect of pertussis vaccine on the thoracic duct lymph and lymphocytes of mice. J Exp Med. 1967 Apr 1;125(4):619–628. doi: 10.1084/jem.125.4.619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Parrott D. M., Ferguson A. Selective migration of lymphocytes within the mouse small intestine. Immunology. 1974 Mar;26(3):571–588. [PMC free article] [PubMed] [Google Scholar]
  24. Paulus H. E., Machleder H. I., Levine S., Yu D. T., MacDonald N. S. Lymphocyte involvement in rheumatoid arthritis. Studies during thoracic duct drainage. Arthritis Rheum. 1977 Jul-Aug;20(6):1249–1262. doi: 10.1002/art.1780200614. [DOI] [PubMed] [Google Scholar]
  25. Pearson C. M., Paulus H. E., Machleder H. I. The role of the lymphocyte and its products in the propagation of joint disease. Ann N Y Acad Sci. 1975 Jun 13;256:150–168. doi: 10.1111/j.1749-6632.1975.tb36044.x. [DOI] [PubMed] [Google Scholar]
  26. Pick E., Turk J. L. The biological activities of soluble lymphocyte products. Clin Exp Immunol. 1972 Jan;10(1):1–23. [PMC free article] [PubMed] [Google Scholar]
  27. Preston P. M., Carter R. L., Leuchars E., Davies A. J., Dumonde D. C. Experimental cutaneous leishmaniasis. 3. Effects of thymectomy on the course of infection of CBA mice with Leishmania tropica. Clin Exp Immunol. 1972 Feb;10(2):337–357. [PMC free article] [PubMed] [Google Scholar]
  28. Schlossman S. F., Levin H. A., Rocklin R. E., David J. R. The compartmentalization of antigen-reactive lymphocytes in desensitized guinea pigs. J Exp Med. 1971 Sep 1;134(3 Pt 1):741–750. doi: 10.1084/jem.134.3.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Smiley J. D., Sachs C., Ziff M. In vitro synthesis of immunoglobulin by rheumatoid synovial membrane. J Clin Invest. 1968 Mar;47(3):624–632. doi: 10.1172/JCI105758. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Smith J. B., Cunningham A. J., Lafferty K. J., Morris B. The role of the lymphatic system and lymphoid cells in the establishment of immunological memory. Aust J Exp Biol Med Sci. 1970 Feb;48(1):57–70. doi: 10.1038/icb.1970.6. [DOI] [PubMed] [Google Scholar]
  31. Steel C. M., Evans J., Smith M. A. Physiological variation in circulating B cell:T cell ratio in man. Nature. 1974 Feb 8;247(5440):387–389. doi: 10.1038/247387a0. [DOI] [PubMed] [Google Scholar]
  32. Talal N., Steinberg A. D. The pathogenesis of autoimmunity in New Zealand black mice. Curr Top Microbiol Immunol. 1974;64(0):79–103. doi: 10.1007/978-3-642-65848-8_3. [DOI] [PubMed] [Google Scholar]
  33. Thursh D. R., Emeson E. E. The immunologically specific retention of recirculating long-lived lymphocytes in lymph nodes stimulated by xenogeneic erythrocytes. J Exp Med. 1972 Apr 1;135(4):754–763. doi: 10.1084/jem.135.4.754. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Turk J. L., Waters M. F. Immunological significance of changes in lymph nodes across the leprosy spectrum. Clin Exp Immunol. 1971 Mar;8(3):363–376. [PMC free article] [PubMed] [Google Scholar]
  35. Wegelius O., Laine V., Lindström B., Klockars M. Fistula of the thoracic duct as immunosuppressive treatment in rheumatoid arthritis. Acta Med Scand. 1970 Jun;187(6):539–544. doi: 10.1111/j.0954-6820.1970.tb02982.x. [DOI] [PubMed] [Google Scholar]
  36. Whitehouse D. J., Whitehouse M. W., Pearson C. M. Passive transfer of adjuvant-induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes. Nature. 1969 Dec 27;224(5226):1322–1322. doi: 10.1038/2241322a0. [DOI] [PubMed] [Google Scholar]
  37. Woodruff J. J., Gesner B. M. The effect of neuraminidase on the fate of transfused lymphocytes. J Exp Med. 1969 Mar 1;129(3):551–567. doi: 10.1084/jem.129.3.551. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Woodruff J., Gesner B. M. Lymphocytes: circulation altered by trypsin. Science. 1968 Jul 12;161(3837):176–178. doi: 10.1126/science.161.3837.176. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES