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. 1978 Nov;93(2):499–513.

Tumor-induced immunosuppression.

H Friedman, S Specter, M Watanabe, S H Pan
PMCID: PMC2018379  PMID: 102206

Abstract

Three tumor systems, including a mastocytoma, plasmacytomas, and a leukemia-lymphoma were studied for their ability to modify humoral immunity to sheep erythrocytes both in vivo and in vitro. All tumors resulted in a depression of the hemolytic antibody plaque-forming cell response in susceptible mice. These studies indicated that the mechanism(s) of suppression, although not fully defined, were different for each model system investigated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ceglowski W. S. Effect of leukemia virus infections on antibody formation and cellular immunity. Ann N Y Acad Sci. 1976;276:411–416. doi: 10.1111/j.1749-6632.1976.tb41666.x. [DOI] [PubMed] [Google Scholar]
  2. Cimprich R. S., Specter S., Friedman H. Murine lymphoma-induced immunosuppression: requirement for direct tumour cell contact. Science. 1978 Apr 7;200(4337):60–61. doi: 10.1126/science.635572. [DOI] [PubMed] [Google Scholar]
  3. Cimprich R. S., Specter S., Friedman H. Requirement for direct cellular contact for immunosuppression by a murine virus-induced lymphoma (FBL-3). J Immunol. 1978 May;120(5):1473–1479. [PubMed] [Google Scholar]
  4. Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
  5. Friedman H., Ceglowski W. S. Virus tumorigenesis and immunity: influence of immunostimulation and immunodepression. Johns Hopkins Med J Suppl. 1974;3:187–209. [PubMed] [Google Scholar]
  6. Friedman H., Kamo I. Preferential depression of IgM producing immunocytes during mastocytoma-induced immunosuppression. Proc Soc Exp Biol Med. 1978 Mar;157(3):381–385. doi: 10.3181/00379727-157-40058. [DOI] [PubMed] [Google Scholar]
  7. Friedman H., Secter S., Kamo I., Kateley J. Tumor-associated immunosuppressive factors. Ann N Y Acad Sci. 1976;276:417–430. doi: 10.1111/j.1749-6632.1976.tb41667.x. [DOI] [PubMed] [Google Scholar]
  8. Heller P., Bhoopalam N., Cabana V., Costea N., Yakulis V. The role of RNA in the immunological deficiency of plasmacytoma. Ann N Y Acad Sci. 1973 May 31;207:468–480. doi: 10.1111/j.1749-6632.1973.tb47509.x. [DOI] [PubMed] [Google Scholar]
  9. Kamo I., Friedman H. Immunosuppression and the role of suppressive factors in cancer. Adv Cancer Res. 1977;25:271–321. doi: 10.1016/s0065-230x(08)60636-3. [DOI] [PubMed] [Google Scholar]
  10. Kamo I., Kateley J., Freidman H. Mastocytoma-induced suppression of in vitro antibody formation. Proc Soc Exp Biol Med. 1975 Mar;148(3):883–886. doi: 10.3181/00379727-148-38653. [DOI] [PubMed] [Google Scholar]
  11. Kamo I., Pan S. H., Friedman H. A simplified procedure for in vitro immunization of dispersed spleen cell cultures. J Immunol Methods. 1976;11(1):55–62. doi: 10.1016/0022-1759(76)90018-1. [DOI] [PubMed] [Google Scholar]
  12. Kamo I., Patel C., Friedman H. Altered immunologic responsiveness in mastocytoma-bearing mice. J Natl Cancer Inst. 1976 Feb;56(2):333–338. doi: 10.1093/jnci/56.2.333. [DOI] [PubMed] [Google Scholar]
  13. Kamo I., Patel C., Kateley J., Friedman H. Immunosuppression induced in vitro by mastocytoma tumor cells and cell-free extracts. J Immunol. 1975 Jun;114(6):1749–1756. [PubMed] [Google Scholar]
  14. Kamo I., Patel C., Patel N., Friedman H. Restoration of in vitro immune responsiveness of mastocytoma-suppressed splenocytes by activated T cells. J Immunol. 1975 Aug;115(2):382–386. [PubMed] [Google Scholar]
  15. Kateley J. R., Kamo I., Kaplan G., Friedman H. Suppressive effect of leukemia virus-infected lymphoid cells on in vitro immunization of normal splenocytes. J Natl Cancer Inst. 1974 Nov;53(5):1371–1378. doi: 10.1093/jnci/53.5.1371. [DOI] [PubMed] [Google Scholar]
  16. Koo G. C., Ceglowski W. S., Higgins M., Friedman H. Immunosuppression by leukemia viruses. VI. Ultrastructure of individual antibody-forming cells in the spleens of friend leukemia virus-infected mice. J Immunol. 1971 Mar;106(3):815–830. [PubMed] [Google Scholar]
  17. Millian S. J., Schaeffer M. Antibody production by mice infected with selected murine oncogenic agents. Cancer. 1968 May;21(5):989–999. doi: 10.1002/1097-0142(196805)21:5<989::aid-cncr2820210524>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  18. Notkins A. L., Mergenhagen S. E., Howard R. J. Effect of virus infections on the function of the immune system. Annu Rev Microbiol. 1970;24:525–538. doi: 10.1146/annurev.mi.24.100170.002521. [DOI] [PubMed] [Google Scholar]
  20. Siegel B. V., Morton J. I. Tumor virus effects on immunocyte precursor cells. Hemopoietic stem cell behavior and leukemogenic susceptibility. Ann N Y Acad Sci. 1976;276:442–454. doi: 10.1111/j.1749-6632.1976.tb41669.x. [DOI] [PubMed] [Google Scholar]
  21. Specter S., Friedman H. Discussion paper: immunosuppression induced in vivo and in vitro by different classes of plasmacytomas. Ann N Y Acad Sci. 1976;276:479–487. doi: 10.1111/j.1749-6632.1976.tb41672.x. [DOI] [PubMed] [Google Scholar]
  22. Specter S., Patel C., Friedman H. Immunosuppression induced in vitro by cell-free extracts of Friend leukemia virusinfected splenocytes. J Natl Cancer Inst. 1976 Jan;56(1):143–147. doi: 10.1093/jnci/56.1.143. [DOI] [PubMed] [Google Scholar]
  23. Stutman O. Immunodepression and malignancy. Adv Cancer Res. 1975;22:261–422. doi: 10.1016/s0065-230x(08)60179-7. [DOI] [PubMed] [Google Scholar]

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