Abstract
OBJECTIVE: To provide an effective approach for family physicians treating children presenting with urinary tract infections (UTIs). QUALITY OF EVIDENCE: The information presented, and articles quoted, are drawn from both review of the literature and recent consensus guidelines. Data and recommendations come from prospective multicentre trials; retrospective reviews; expert consensus statements; and some smaller trials, commentaries, and editorials. MAIN MESSAGE: Urinary tract infections are often seen in family practice. Diagnosis requires suspicion and a realization that children, especially those younger than 2 years, often have very few, nonspecific signs of infection. Obtaining a proper urine sample is vital, because true infections require radiographic studies. Antibiotic prophylaxis is promoted because of the link between vesicoureteral reflux, recurrent UTIs, and renal scarring and hypertension. We generally provide prophylaxis until children are 3 or 4 years, when risk of damage from reflux is lessened and timely urine samples are easier to obtain for prompt therapy. Surgical opinion is sought only when medical management has failed. Failure is defined as either recurrent infections and pyelonephritis or poor renal growth. CONCLUSION: To diagnose UTIs in children, physicians must suspect them, obtain proper urine samples, order appropriate investigations to rule out underlying anatomic abnormalities, and treat with appropriate antibiotics considering both organism sensitivities and length of therapy.
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Selected References
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- Bailey R. R., Lynn K. L., Robson R. A. End-stage reflux nephropathy. Ren Fail. 1994;16(1):27–35. doi: 10.3109/08860229409044845. [DOI] [PubMed] [Google Scholar]
- Brendstrup L., Hjelt K., Petersen K. E., Petersen S., Andersen E. A., Daugbjerg P. S., Stagegaard B. R., Nielsen O. H., Vejlsgaard R., Schou G. Nitrofurantoin versus trimethoprim prophylaxis in recurrent urinary tract infection in children. A randomized, double-blind study. Acta Paediatr Scand. 1990 Dec;79(12):1225–1234. doi: 10.1111/j.1651-2227.1990.tb11414.x. [DOI] [PubMed] [Google Scholar]
- Fisher M. C. Pyelonephritis at home-why not? Pediatrics. 1999 Jul;104(1 Pt 1):109–111. doi: 10.1542/peds.104.1.109. [DOI] [PubMed] [Google Scholar]
- Goldraich N. P., Goldraich I. H. Followup of conservatively treated children with high and low grade vesicoureteral reflux: a prospective study. J Urol. 1992 Nov;148(5 Pt 2):1688–1692. doi: 10.1016/s0022-5347(17)37003-9. [DOI] [PubMed] [Google Scholar]
- Hellerstein S. Recurrent urinary tract infections in children. Pediatr Infect Dis. 1982 Jul-Aug;1(4):271–281. doi: 10.1097/00006454-198207000-00018. [DOI] [PubMed] [Google Scholar]
- Hellström A., Hanson E., Hansson S., Hjälmås K., Jodal U. Association between urinary symptoms at 7 years old and previous urinary tract infection. Arch Dis Child. 1991 Feb;66(2):232–234. doi: 10.1136/adc.66.2.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoberman A., Wald E. R., Hickey R. W., Baskin M., Charron M., Majd M., Kearney D. H., Reynolds E. A., Ruley J., Janosky J. E. Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics. 1999 Jul;104(1 Pt 1):79–86. doi: 10.1542/peds.104.1.79. [DOI] [PubMed] [Google Scholar]
- Jodal U., Koskimies O., Hanson E., Löhr G., Olbing H., Smellie J., Tamminen-Möbius T. Infection pattern in children with vesicoureteral reflux randomly allocated to operation or long-term antibacterial prophylaxis. The International Reflux Study in Children. J Urol. 1992 Nov;148(5 Pt 2):1650–1652. doi: 10.1016/s0022-5347(17)36994-x. [DOI] [PubMed] [Google Scholar]
- Jodal U. The natural history of bacteriuria in childhood. Infect Dis Clin North Am. 1987 Dec;1(4):713–729. [PubMed] [Google Scholar]
- Lidefelt K. J., Bollgren I., Nord C. E. Changes in periurethral microflora after antimicrobial drugs. Arch Dis Child. 1991 Jun;66(6):683–685. doi: 10.1136/adc.66.6.683. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McEnery P. T., Alexander S. R., Sullivan K., Tejani A. Renal transplantation in children and adolescents: the 1992 annual report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol. 1993 Dec;7(6):711–720. doi: 10.1007/BF01213331. [DOI] [PubMed] [Google Scholar]
- Olbing H., Claësson I., Ebel K. D., Seppänen U., Smellie J. M., Tamminen-Möbius T., Wikstad I. Renal scars and parenchymal thinning in children with vesicoureteral reflux: a 5-year report of the International Reflux Study in Children (European branch). J Urol. 1992 Nov;148(5 Pt 2):1653–1656. doi: 10.1016/s0022-5347(17)36995-1. [DOI] [PubMed] [Google Scholar]
- Pezzlo M. Detection of urinary tract infections by rapid methods. Clin Microbiol Rev. 1988 Jul;1(3):268–280. doi: 10.1128/cmr.1.3.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ransley P. G. Vesicoureteric reflux: continuing surgical dilemma. Urology. 1978 Sep;12(3):246–255. doi: 10.1016/0090-4295(78)90387-4. [DOI] [PubMed] [Google Scholar]
- Skoog S. J., Belman A. B., Majd M. A nonsurgical approach to the management of primary vesicoureteral reflux. J Urol. 1987 Oct;138(4 Pt 2):941–946. doi: 10.1016/s0022-5347(17)43465-3. [DOI] [PubMed] [Google Scholar]
- Smellie J. M. Commentary: management of children with severe vesicoureteral reflux. J Urol. 1992 Nov;148(5 Pt 2):1676–1678. doi: 10.1016/s0022-5347(17)37000-3. [DOI] [PubMed] [Google Scholar]
- Smellie J. M., Grüneberg R. N., Bantock H. M., Prescod N. Prophylactic co-trimoxazole and trimethoprim in the management of urinary tract infection in children. Pediatr Nephrol. 1988 Jan;2(1):12–17. doi: 10.1007/BF00870372. [DOI] [PubMed] [Google Scholar]
- Smellie J. M., Tamminen-Möbius T., Olbing H., Claesson I., Wikstad I., Jodal U., Seppänen U. Five-year study of medical or surgical treatment in children with severe reflux: radiological renal findings. The International Reflux Study in Children. Pediatr Nephrol. 1992 May;6(3):223–230. doi: 10.1007/BF00878353. [DOI] [PubMed] [Google Scholar]
- Smellie J. M. Vesico-ureteric reflux. Acta Paediatr. 1999 Nov;88(11):1182–1183. doi: 10.1080/080352599750030266. [DOI] [PubMed] [Google Scholar]
- Weiss R., Duckett J., Spitzer A. Results of a randomized clinical trial of medical versus surgical management of infants and children with grades III and IV primary vesicoureteral reflux (United States). The International Reflux Study in Children. J Urol. 1992 Nov;148(5 Pt 2):1667–1673. doi: 10.1016/s0022-5347(17)36998-7. [DOI] [PubMed] [Google Scholar]
