Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1964 Jun;39(205):250–256. doi: 10.1136/adc.39.205.250

Hydroxykynureninuria

A case of Abnormal Tryptophan Metabolism Probably Due to a Deficiency of Kynureninase

G M Komrower, Vera Wilson, J R Clamp, R G Westall
PMCID: PMC2019216  PMID: 14169454

Full text

PDF
250

Images in this article

253Fig. 2
on p.253

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BESSEY O. A., ADAM D. J., HANSEN A. E. Intake of vitamin B6 and infantile convulsions: a first approximation of requirements of pyridoxine in infants. Pediatrics. 1957 Jul;20(1 Pt 1):33–44. [PubMed] [Google Scholar]
  2. BOYLAND E., WILLIAMS D. C. The metabolism of tryptophan. 2. The metabolism of tryptophan in patients suffering from cancer of the bladder. Biochem J. 1956 Nov;64(3):578–582. doi: 10.1042/bj0640578. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CHARCONNET-HARDING F., DALGLIESH C. E., NEUBERGER A. The relation between riboflavin and tryptophan metabolism, studied in the rat. Biochem J. 1953 Mar;53(4):513–521. doi: 10.1042/bj0530513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. COURSIN D. B. Present status of Vitamin B6 metabolism. Am J Clin Nutr. 1961 May-Jun;9:304–314. doi: 10.1093/ajcn/9.3.304. [DOI] [PubMed] [Google Scholar]
  5. DALGLIESH C. E. Two-dimensional paper chromatography of urinary indoles and related substances. Biochem J. 1956 Nov;64(3):481–485. doi: 10.1042/bj0640481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GREGORY I. The role of nicotinic acid (niacin) in mental health and disease. Section a: the aetiology and psychiatric manifestations of pellagra. J Ment Sci. 1955 Jan;101(422):85–109. doi: 10.1192/bjp.101.422.85. [DOI] [PubMed] [Google Scholar]
  7. HUNT A. D., Jr, STOKES J., Jr, McCRORY W. W., STROUD H. H. Pyridoxine dependency: report of a case of intractable convulsions in an infant controlled by pyridoxine. Pediatrics. 1954 Feb;13(2):140–145. [PubMed] [Google Scholar]
  8. JOHNSTON C. C., MASON M. Tryptophan metabolism: formation of beta-(8-xanthurenyl)-glucosiduronic acid in the rat and in rat kidney slices. J Biol Chem. 1962 Jan;237:29–33. [PubMed] [Google Scholar]
  9. MARVER H. S. Studies on tryptophan metabolism. I. Urinary tryptophan metabolites in hypoplastic anemias and other hematologic disorders. J Lab Clin Med. 1961 Sep;58:425–436. [PubMed] [Google Scholar]
  10. MILNE M. D., CRAWFORD M. A., GIRAO C. B., LOUGHRIDGE L. The excretion of indolylacetic acid and related indolic acids in man and the rat. Clin Sci. 1960 Feb;19:165–179. [PubMed] [Google Scholar]
  11. MOLONY C. J., PARMELEE A. H. Convulsions in young infants as a result of pyridoxine (vitamin B6) deficiency. J Am Med Assoc. 1954 Jan 30;154(5):405–406. doi: 10.1001/jama.1954.02940390029008. [DOI] [PubMed] [Google Scholar]
  12. MUSAJO L., BENASSI C. A., PARPAJOLA A. Excretion and isolation of kynurenine and 3-hydroxykynurenine from human pathological urine. Clin Chim Acta. 1956 May-Jun;1(3):229–235. doi: 10.1016/0009-8981(56)90069-9. [DOI] [PubMed] [Google Scholar]
  13. PRICE J. M., BROWN R. R., PETERS H. A. Tryptophan metabolism in porphyria, schizophrenia, and a variety of neurologic and psychiatric diseases. Neurology. 1959 Jul;9(7):456–468. doi: 10.1212/wnl.9.7.456. [DOI] [PubMed] [Google Scholar]
  14. SCRIVER C. R. Vitamin B6-dependency and infantile convulsions. Pediatrics. 1960 Jul;26:62–74. [PubMed] [Google Scholar]
  15. TOMPSETT S. L. The determination in urine of some metabolites of tryptophankynurenine, anthranilic acid and 3-hydroxyanthranilic acid- and reference to the presence of o-aminophenol in urine. Clin Chim Acta. 1959 May;4(3):411–419. doi: 10.1016/0009-8981(59)90112-3. [DOI] [PubMed] [Google Scholar]
  16. VASSELLA F., HELLSTROM B., WENGLE B. Urinary excretion of tryptophan metabolites in the healthy infant. Pediatrics. 1962 Oct;30:585–591. [PubMed] [Google Scholar]
  17. WACHSTEIN M., GUDAITIS A. Detection of vitamin B6 deficiency; utilization of an improved method for rapid determination of xanthurenic acid in urine. Am J Clin Pathol. 1952 Jul;22(7):652–655. doi: 10.1093/ajcp/22.7.652. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES