Skip to main content
PMC home page
Applied and Environmental Microbiology logoLink to Applied and Environmental Microbiology
. 1994 Nov;60(11):4207–4209. doi: 10.1128/aem.60.11.4207-4209.1994

Duplication of the lantibiotic structural gene in M-type 49 group A streptococcus strains producing streptococcin A-M49.

W L Hynes 1, V L Friend 1, J J Ferretti 1
PMCID: PMC201964  PMID: 7993103

Abstract

Streptococcin A-M49 is produced by certain strains of M-type 49 group A streptococci. The structural gene for streptococcin A-M49 was cloned after hybridization with a probe containing the scnA lantibiotic structural gene. Sequence analysis revealed a duplication of the scnA gene; each gene (scnA' and scnA") encoded a 51-amino-acid prepeptide.

Full text

PDF
4207

Images in this article

4207Image
on p.4207

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banerjee S., Hansen J. N. Structure and expression of a gene encoding the precursor of subtilin, a small protein antibiotic. J Biol Chem. 1988 Jul 5;263(19):9508–9514. [PubMed] [Google Scholar]
  2. Buchman G. W., Banerjee S., Hansen J. N. Structure, expression, and evolution of a gene encoding the precursor of nisin, a small protein antibiotic. J Biol Chem. 1988 Nov 5;263(31):16260–16266. [PubMed] [Google Scholar]
  3. Huang T. T., Malke H., Ferretti J. J. Heterogeneity of the streptokinase gene in group A streptococci. Infect Immun. 1989 Feb;57(2):502–506. doi: 10.1128/iai.57.2.502-506.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hynes W. L., Ferretti J. J., Gilmore M. S., Segarra R. A. PCR amplification of streptococcal DNA using crude cell lysates. FEMS Microbiol Lett. 1992 Jul 1;73(1-2):139–142. doi: 10.1016/0378-1097(92)90597-h. [DOI] [PubMed] [Google Scholar]
  5. Hynes W. L., Ferretti J. J., Tagg J. R. Cloning of the gene encoding Streptococcin A-FF22, a novel lantibiotic produced by Streptococcus pyogenes, and determination of its nucleotide sequence. Appl Environ Microbiol. 1993 Jun;59(6):1969–1971. doi: 10.1128/aem.59.6.1969-1971.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kaletta C., Entian K. D., Jung G. Prepeptide sequence of cinnamycin (Ro 09-0198): the first structural gene of a duramycin-type lantibiotic. Eur J Biochem. 1991 Jul 15;199(2):411–415. doi: 10.1111/j.1432-1033.1991.tb16138.x. [DOI] [PubMed] [Google Scholar]
  7. Kaletta C., Entian K. D., Kellner R., Jung G., Reis M., Sahl H. G. Pep5, a new lantibiotic: structural gene isolation and prepeptide sequence. Arch Microbiol. 1989;152(1):16–19. doi: 10.1007/BF00447005. [DOI] [PubMed] [Google Scholar]
  8. Kaletta C., Entian K. D. Nisin, a peptide antibiotic: cloning and sequencing of the nisA gene and posttranslational processing of its peptide product. J Bacteriol. 1989 Mar;171(3):1597–1601. doi: 10.1128/jb.171.3.1597-1601.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Piard J. C., Kuipers O. P., Rollema H. S., Desmazeaud M. J., de Vos W. M. Structure, organization, and expression of the lct gene for lacticin 481, a novel lantibiotic produced by Lactococcus lactis. J Biol Chem. 1993 Aug 5;268(22):16361–16368. [PubMed] [Google Scholar]
  10. Rauch P. J., De Vos W. M. Characterization of the novel nisin-sucrose conjugative transposon Tn5276 and its insertion in Lactococcus lactis. J Bacteriol. 1992 Feb;174(4):1280–1287. doi: 10.1128/jb.174.4.1280-1287.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ross K. F., Ronson C. W., Tagg J. R. Isolation and characterization of the lantibiotic salivaricin A and its structural gene salA from Streptococcus salivarius 20P3. Appl Environ Microbiol. 1993 Jul;59(7):2014–2021. doi: 10.1128/aem.59.7.2014-2021.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Schnell N., Entian K. D., Götz F., Hörner T., Kellner R., Jung G. Structural gene isolation and prepeptide sequence of gallidermin, a new lanthionine containing antibiotic. FEMS Microbiol Lett. 1989 Apr;49(2-3):263–267. doi: 10.1016/0378-1097(89)90050-5. [DOI] [PubMed] [Google Scholar]
  13. Schnell N., Entian K. D., Schneider U., Götz F., Zähner H., Kellner R., Jung G. Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings. Nature. 1988 May 19;333(6170):276–278. doi: 10.1038/333276a0. [DOI] [PubMed] [Google Scholar]
  14. Tagg J. R., Skjold S. A. A bacteriocin produced by certain M-type 49 Streptococcus pyogenes strains when incubated anaerobically. J Hyg (Lond) 1984 Oct;93(2):339–344. doi: 10.1017/s0022172400064883. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Applied and Environmental Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES