Abstract
Blood and plasma histamine levels, together with circulating basophil and eosinophil counts, were estimated in a group of asthmatic children.
Short-term studies were carried out on 7 patients, each of whom was given a single dose of corticosteroid, and the effects of the hormone were monitored for periods of up to two hours. Usually a fall occurred in the whole blood histamine level, basophil count, and eosinophil count, but no change occurred in the plasma histamine level, which remained very low throughout.
In 3 cases, follow-up studies showed that in 2 cases out of 3, whole blood histamine levels were lower during treatment with corticosteroids, than when steroids were not being given.
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Selected References
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- ADAM H. M., HARDWICK D. C., SPENCER K. E. Assay of histamine on the isolated guinea-pig intestine by the method of superfusion. Br J Pharmacol Chemother. 1954 Sep;9(3):360–366. doi: 10.1111/j.1476-5381.1954.tb01693.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ARCHER R. K. Eosinophil leucocyte-attracting effect of histamine in skin. Nature. 1960 Jul 9;187:155–156. doi: 10.1038/187155a0. [DOI] [PubMed] [Google Scholar]
- CODE C. F., MITCHELL R. G. Histamine, eosinophils and basophils in the blood. J Physiol. 1957 May 23;136(3):449–468. doi: 10.1113/jphysiol.1957.sp005773. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DEGARA P. F. Chemical determination of histamine in blood in health and disease. J Allergy. 1951 Sep;22(5):429–433. doi: 10.1016/0021-8707(51)90146-3. [DOI] [PubMed] [Google Scholar]
- Kovacs E. M., Suffiad K. Histamine release by cortisone induced hyperglycaemia. Br J Pharmacol Chemother. 1968 Feb;32(2):262–272. doi: 10.1111/j.1476-5381.1968.tb00970.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MITCHELL R. G., CASS R. Histamine and 5-hydroxytryptamine in the blood of infants and children. J Clin Invest. 1959 Apr;38(4):595–604. doi: 10.1172/JCI103837. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MITCHELL R. G., CODE C. F. Urinary excretion of histamine after administration of cortisone. J Clin Endocrinol Metab. 1954 Jul;14(7):707–710. doi: 10.1210/jcem-14-7-707. [DOI] [PubMed] [Google Scholar]
- MITCHELL R. G. Circulating basophilic leucocyte counts in the newborn. Arch Dis Child. 1955 Apr;30(150):130–132. doi: 10.1136/adc.30.150.130. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MOORE J. E., 3rd, JAMES G. W., 3rd A simple direct method for absolute basophil leucocyte count. Proc Soc Exp Biol Med. 1953 Apr;82(4):601–603. doi: 10.3181/00379727-82-20190. [DOI] [PubMed] [Google Scholar]
- NOAH J. W., BRAND A. The effect of corticosteroid administration upon blood histamine content. J Allergy. 1957 Sep;28(5):405–413. doi: 10.1016/0021-8707(57)90094-1. [DOI] [PubMed] [Google Scholar]